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公开(公告)号：AU2006242380A1
公开(公告)日：2006-11-09
申请号：AU2006242380
申请日：2006-05-01
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , DELISLE ROBERT KIRK , VOEGTLI WALTER CHARLES , ROBINSON JOHN E , LYSSIKATOS JOSEPH P , LAIRD ELLEN , ALLEN SHELLEY , WALLACE ELI M , CORRETTE CHRISTOPHER P , ZHAO QIAN
IPC: C07D417/04
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：CA2584866A1
公开(公告)日：2006-04-27
申请号：CA2584866
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , ZHAO QIAN , ROBINSON JOHN , ALLEN SHELLEY , LYSSIKATOS JOSEPH P , LAIRD ELLEN , AICHER TOM , WALLACE ELI M
IPC: A61K31/4245 , C07D413/00 , C07D417/00
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：MX386316B
公开(公告)日：2025-03-18
申请号：MX2017007284
申请日：2017-06-05
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： BENNETT BRYDON L , KRASER CHRISTOPHER F , LAIRD ELLEN , HICKEN ERIK JAMES , JAY BRADFORD FELL , PHENEGER JED , ROBINSON JOHN E , GAUDINO JOHN , FISCHER JOHN P , LEFTHERIS KATERINA , BURGESS LAURENCE E , CHICARELLI MARK J , BOYS MARK LAURENCE , RAHEJA RAJ K , RIEGER ROBERT ANDREW , HINKLIN RONALD JAY , ALLEN SHELLEY , TANG TONY P , SATOH YOSHITAKA
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
Abstract: Compuestos de Fórmula I: y estereoisómeros y sales solvatos farmacéuticamente aceptables de estos en los que R1, R2, R3 y R4 tienen los significados dados en la memoria descriptiva, son inhibidores de una o más JAK cinasas y son útiles en el tratamiento de enfermedades y trastornos relacionados con la JAK cinasa, tales como enfermedades autoinmunitarias, rechazo del trasplante de órganos, tejidos y células, así como también neoplasias y trastornos hematológicos y sus comorbilidades.
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公开(公告)号：DK3227297T3
公开(公告)日：2021-04-06
申请号：DK15819933
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
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公开(公告)号：AU2015357585A1
公开(公告)日：2017-07-13
申请号：AU2015357585
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
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Patent Agency Ranking
公开(公告)号：CA2868912C
公开(公告)日：2017-01-03
申请号：CA2868912
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC: A61K31/433 , A61K31/4439 , A61K38/05 , A61P35/02
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders (see above formula)
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公开(公告)号：CA2852516C
公开(公告)日：2015-06-02
申请号：CA2852516
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC: C07D285/12
Abstract: This invention relates to processes for preparing inhibitors of mitotic kinesins, particularly KSP.
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公开(公告)号：ZA201208544B
公开(公告)日：2015-04-29
申请号：ZA201208544
申请日：2012-11-13
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , GRONEBERG ROBERT D , HUANG LILY , KRASER CHRISTOPHER F , TARLTON EUGENE , BURGERSS LAURENCE E , HARVEY DARREN M , KERCHER TIMOTHY , LAIRD ELLEN , ZHAO QIAN
IPC: A61K20060101 , A61P20060101 , C07D20060101
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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公开(公告)号：NZ603446A
公开(公告)日：2014-05-30
申请号：NZ60344611
申请日：2011-04-11
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , BURGESS LAURENCE E , GRONEBERG ROBERT D , HARVEY DARREN M , HUANG LILY , KERCHER TIMOTHY , KRASER CHRISTOPHER F , LAIRD ELLEN , TARLTON EUGENE , ZHAO QIAN
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
Abstract: Disclosed are 5,7-substituted-imidazo[1,2-C]pyrimidine’s as inhibitors of JAK kinases of formula (I). The compounds are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their comorbidities. Examples of compounds of formula (I) are: 2-(3-(3-(7-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile hydrochloride; 3-Cyclopropyl-3-(3-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile; and 3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for the treatment of an autoimmune disease or inflammatory disease; organ, tissue or cell transplant rejection; or malignancy.
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公开(公告)号：AU2012323399A1
公开(公告)日：2014-05-29
申请号：AU2012323399
申请日：2012-10-09
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , BURGESS LAURENCE E , EARY C TODD , GRONEBERG ROBERT , HACHE BRUNO P , HARVEY DARREN , HICKEN ERIK JAMES , KRASER CHRISTOPHER F , LAIRD ELLEN , MORENO DAVID A , MUNSON MARK C , REN LI , ROBINSON JOHN E , SCHLACHTER STEPHEN T
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
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