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公开(公告)号：WO03077855A2
公开(公告)日：2003-09-25
申请号：PCT/US0307565
申请日：2003-03-13
Applicant: ARRAY BIOPHARMA INC , WALLACE ELI M , LYSSIKATOS JOSEPH P , HURLEY BRIAN T , MARLOW ALLISON L
Inventor： WALLACE ELI M , LYSSIKATOS JOSEPH P , HURLEY BRIAN T , MARLOW ALLISON L
IPC: C07D235/08 , A61K31/4184 , A61K31/4439 , A61K31/5377 , A61P35/00 , C07D235/06 , C07D401/04 , C07D401/06 , C07D403/06 , A61K
CPC classification number: C07D235/06 , C07D401/06 , C07D403/06
Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R , R , R , R , R , R and R are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
Abstract translation: 公开了式（I）化合物及其药学上可接受的盐和前药，其中W，t，R 1，R 2，R 7，R 9，R 10，R 11 >和R 12如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增殖性疾病，如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：EP1682138A4
公开(公告)日：2007-01-24
申请号：EP04811727
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM
IPC: C07D213/80 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/4353 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , A61P35/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
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公开(公告)号：EP1482932A4
公开(公告)日：2006-04-05
申请号：EP03714148
申请日：2003-03-13
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI M , LYSSIKATOS JOSEPH P , HURLEY BRIAN T , MARLOW ALLISON L
IPC: A61K31/4184 , C07D235/08 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P1/18 , A61P3/10 , A61P9/08 , A61P9/10 , A61P13/08 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D235/04 , C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
CPC classification number: C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
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公开(公告)号：EP1482944A4
公开(公告)日：2006-04-19
申请号：EP03716498
申请日：2003-03-13
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI M , LYSSIKATOS JOSEPH P , HURLEY BRIAN T , MARLOW ALLISON L
IPC: A61K31/5377 , C07D235/08 , A61K31/4184 , A61K31/4439 , A61P35/00 , C07D235/06 , C07D235/14 , C07D401/04 , C07D401/06 , C07D403/02 , C07D403/06 , C07D413/02
CPC classification number: C07D235/06 , C07D401/06 , C07D403/06
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公开(公告)号：EP2663555A4
公开(公告)日：2014-07-16
申请号：EP12733896
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY CHARLES TODD , GRONEBERG ROBERT D , JONES ZACHARY , LYSSIKATOS JOSEPH P , YANG HONG WOON
IPC: A61K31/55 , A61P37/00 , C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
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Patent Agency Ranking
公开(公告)号：EP1689387A4
公开(公告)日：2007-08-29
申请号：EP04811726
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , YANG HONG WOON , LYSSIKATOS JOSEPH P
IPC: C07D213/80 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/4353 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , A61P35/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
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37.发明公开CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS 审中-公开氰基胍和CYANOAMIDINE ALS erbB2与EGFR抑制剂
公开(公告)号：EP1567506A4
公开(公告)日：2007-06-20
申请号：EP03768789
申请日：2003-11-10
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , TOPALOV GEORGE , ZHAO QIAN , LYSSIKATOS JOSEPH P
IPC: A61P31/18 , A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04 , C07D417/14 , A61K31/4706 , A61K31/517 , C07D215/42
CPC classification number: C07D417/14 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04
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公开(公告)号：EP2467377A4
公开(公告)日：2013-01-02
申请号：EP10810563
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
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公开(公告)号：EP1922307A4
公开(公告)日：2009-12-30
申请号：EP06836069
申请日：2006-05-17
Applicant: ARRAY BIOPHARMA INC , ASTRAZENECA AB
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC: C07D237/24 , A61K31/501 , A61P35/00 , C07D213/80 , C07D213/82 , C07D213/85
CPC classification number: C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
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公开(公告)号：EP1809280A4
公开(公告)日：2009-10-21
申请号：EP05819172
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC: A61K31/4245 , C07D413/00 , C07D417/00
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
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