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公开(公告)号：CZ20000036A3
公开(公告)日：2001-03-14
申请号：CZ20000036
申请日：1998-07-03
Applicant: BASF AG
Inventor： STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , LE BRIS THEOPHILE-MARIE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC classification number: C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
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公开(公告)号：BG104122A
公开(公告)日：2000-11-30
申请号：BG10412200
申请日：2000-02-03
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHAFER BERND , THYES MARCO , HOEGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: The invention relates to a salt of the fumaric acid with 2-{3-[4-(2-tret.-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1 -yl]propylmercapto}pyrimidin-4-ol and to a pharmaceutical form containing it. The salt can be used for the treatment of diseases dependant on dopamine-D3-ligands. It is very stable at low pH adn is, therefore, particularly suitable for peroral administration. 3 claims
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公开(公告)号：CZ2000450A3
公开(公告)日：2000-10-11
申请号：CZ2000450
申请日：1998-08-14
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHAFER BERND , THYES MARCO , HOEGER THOMAS
IPC: A61K31/505 , C07D239/56
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公开(公告)号：ID24839A
公开(公告)日：2000-08-24
申请号：ID991726
申请日：1998-07-03
Applicant: BASF AG
Inventor： STARK DOROTHEA , BLANK STEFAN , TREIBER HANS-JORG , UNGER LILIANE
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
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公开(公告)号：BG104056A
公开(公告)日：2000-07-31
申请号：BG10405600
申请日：2000-01-04
Applicant: BASF AG
Inventor： STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JORG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , LE BRIS THEOPHILE-MARIE , TESCHENDORF HANS-JURGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The compounds have high dopamine-D-receptor activity and can be used for the treatment of diseases dependent on dopamine-D3-ligands. The triazole compounds have the formula where Ar1, A, B and Ar2 have the meanings listed in the description. 15 claims
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Patent Agency Ranking
公开(公告)号：AU717726B2
公开(公告)日：2000-03-30
申请号：AU1440797
申请日：1997-01-10
Applicant: BASF AG
Inventor： TREIBER HANS-JORG , BLANK STEFAN , STARCK DOROTHEA , UNGER LILIANE , TESCHENDORF HANS-JURGEN , WICKE KARSTEN
IPC: C07D243/08 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: Aza- and diazacyclohexane and -cyclooctane compounds of the following formula:where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号：NO20000665L
公开(公告)日：2000-02-10
申请号：NO20000665
申请日：2000-02-10
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHOFER BERND , THYES MARCO , HOEGER THOMAS
IPC: A61K20060101 , A61K31/395 , C07D239/56 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.
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公开(公告)号：NO20000048A
公开(公告)日：2000-01-06
申请号：NO20000048
申请日：2000-01-06
Applicant: BASF AG
Inventor： STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULTZ , BRIS THEOPHILE-MARIE LE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC classification number: C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
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公开(公告)号：DE19735410A1
公开(公告)日：1999-02-18
申请号：DE19735410
申请日：1997-08-14
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHAEFER BERND , THYES MARCO , HOEGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: The fumaric acid salt (A) of 2-(3-(4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl)propylmercapto)pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new.
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公开(公告)号：IL125076D0
公开(公告)日：1999-01-26
申请号：IL12507697
申请日：1997-01-10
Applicant: BASF AG
Inventor： TREIBER HANS-JOERG , BLANK STEFAN , STARCK DOROTHEA , UNGER LILIANE , TESCHEDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D243/08 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D
Abstract: Aza- and diazacyclohexane and -cyclooctane compounds of the following formula:where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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