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    PREPARATION OF 5-HYDROXYMETHYLIMIDAZOLES
    32.
    发明专利
    PREPARATION OF 5-HYDROXYMETHYLIMIDAZOLES 未知

    公开(公告)号：CA1134839A

    公开(公告)日：1982-11-02

    申请号：CA346104

    申请日：1980-02-19

    Applicant: BASF AG

    Inventor： KEMPE UWE ,  DOCKNER TONI ,  FRANK ANTON ,  KARN HELMUT

    IPC: C07D233/54 ,  C07D233/64

    Abstract: The invention is concerned with a process for the preparation of a 5-hydroxymethylimidazole of the formula 1 1 where R1 is hydrogen or alkyl of 1 to 18 carbon atoms, phenyl, benzyl or .beta.-phenylethyl, and R2 is alkyl of 1 to 18 carbon atoms or phenyl, wherein an imdazole of the formula 2 2 where R1 and R2 have the meanings given for formula 1, is reacted with formaldehyde or an oligomer of formaldehyde is aqueous hydrochloric acid solution, containing from 5 to 18% by weight of hydrogen chloride, at from 80.degree. to 160.degree.C, if appropriate in a closed system under pressure, the resulting 5hydroxymethylimidazole is isolated in the form of its hydrochloride and the ratio of imidazole to hydrogen chloride being from 1:1.5 to 1:5. The process according to the present invention is particularly usable to prepare 5-hydroxymethylimidazoles in a very simple manner, and in a form free from by-products, on an industrial scale.

    PROCESS FOR PREPARING 5-(HYDROXYMETHYL)IMIDAZOLES
    33.
    发明专利
    PROCESS FOR PREPARING 5-(HYDROXYMETHYL)IMIDAZOLES 未知

    公开(公告)号：DE3060433D1

    公开(公告)日：1982-07-08

    申请号：DE3060433

    申请日：1980-02-29

    Applicant: BASF AG

    Inventor： KEMPE UWE DR ,  DOCKNER TONI DR ,  FRANK ANTON ,  KARN HELMUT

    IPC: C07D233/54 ,  C07D233/64

    Abstract: A process for the manufacture of 5-hydroxymethylimidazoles by reaction of an imidazole with formaldehyde or an oligomer of formaldehyde in aqueous hydrochloric acid solution containing from 5 to 18% by weight of hydrogen chloride, at from 80 DEG to 160 DEG C., if desired in a closed system under pressure, followed by isolation in the form of its hydrochloride of the 5-hydroxymethylimidazole obtained.

    Imidazole derivs. prodn. - by reacting 1,2-di:amine with carboxylic acid or dehydrogenating imidazoline in presence of zinc oxide
    37.
    发明专利
    Imidazole derivs. prodn. - by reacting 1,2-di:amine with carboxylic acid or dehydrogenating imidazoline in presence of zinc oxide 未知

    公开(公告)号：DE2729017A1

    公开(公告)日：1979-01-18

    申请号：DE2729017

    申请日：1977-06-28

    Applicant: BASF AG

    Inventor： DOCKNER TONI DIPL CHEM DR ,  FRANK ANTON

    IPC: C07D233/54 ,  C07D233/58

    Abstract: Prodn. of imidazoles of formula (I) comprises (a) reacting 1,2-diamines of formula (II) with carboxylic acids of formula (III) or (b) dehydrogenating 2-imidazolines of formula (IV), in either case by heating at 300-600 degrees C in the presence of zinc oxide or a mixt. of zinc oxide and aluminium oxide as catalyst: (R1 - R4 = H or an aliphatic, araliphatic, cycloaliphatic or aromatic residue). (I) are intermediates for dyes, plant protection agents, textile aids, polyurethane and epoxy resin catalysts, surfactants and pharmaceuticals (e.g. nitroimidazoles). They can also be used as catalysts for polymerisations and aldol condensations. (I) is obtd. in good yields and purity. The catalysts used are cheap and easily regenerated, and are not significantly poisoned after prolonged use.

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