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    32.
    发明专利
    未知

    公开(公告)号：BRPI0514955A

    公开(公告)日：2008-07-01

    申请号：BRPI0514955

    申请日：2005-09-02

    Applicant: BASF AG

    Inventor： BLETTNER CARSTEN ,  BLASCO JORDI TORMO I ,  MUELLER BERND ,  GEWEHR MARKUS ,  GRAMMENOS WASSILIOS ,  GROTE THOMAS ,  HUENGER UDO ,  RHEINHEIMER JOACHIM ,  SCHOFER PETER ,  SCHIEWECK FRANK ,  GLER ANJA SCHW ,  DIETZ JOCHEN ,  SPEAKMAN JOHN-BRYAN ,  JABS THORSTEN ,  STRATHMANN SIEGFRIED ,  FL ULRICH SCH ,  SCHERER MARIA ,  STIERL REINHARD

    IPC: C07D487/04 ,  A01N43/90 ,  C07D239/00 ,  C07D249/00

    Abstract: 6-Phenyl-7-aminotriazolopyrimidines of the formula I in which the substituents are as defined below: R 1 is hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, cycloalkenyl, halocycloalkenyl, alkynyl, haloalkynyl or phenyl, naphthyl, or a five- or six-membered saturated, partially unsaturated or aromatic heterocycle, which comprises one to four heteroatoms from the group consisting of O, N and S, R 2 is alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, cycloalkenyl, halocycloalkenyl, alkynyl, haloalkynyl or phenyl, naphthyl, or a five- or six-membered saturated, partially unsaturated or aromatic heterocycle which comprises one to four heteroatoms from the group consisting of O, N and S, R 3 ,R 4 ,R 5 ,R 6 ,R 7 are hydrogen or one of the groups mentioned under R 2 , R 4 , together with R 3 or R 6 , may also form a five- or six-membered saturated or unsaturated ring which, in addition to carbon atoms, may comprise one to three further heteroatoms from the group consisting of O, N and S as ring members; R 2 with R 3 , R 4 with R 5 , R 6 with R 7 may in each case together, with formation of spiro groups, also form a C 2 -C 5 -alkylene, or alkenylene or alkynylene chain which may be interrupted by one to three heteroatoms from the group consisting of O, N and S; p is zero or 1; L is halogen, alkyl, haloalkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, alkylcarbonylamino, C(O)-R, S(O) n -R; where n is zero, 1 or 2; R is hydrogen, alkyl, haloalkyl, alkoxy, alkenyloxy, alkynyloxy, amino, alkylamino, dialkylamino; m is 1, 2, 3, 4 or 5; X is halogen, cyano, alkyl, alkoxy, alkenyloxy, alkynyloxy or haloalkoxy; Y is oxygen or sulfur; Z is hydrogen, alkyl, haloalkyl, cycloalkyl, alkylcarbonyl, cycloalkylcarbonyl, alkenyl, haloalkenyl, cycloalkenyl, alkynyl, haloalkynyl, phenyl, naphthyl, a five- to ten-membered saturated, partially unsaturated or aromatic heterocycle which comprises one to four heteroatoms from the group consisting of O, N and S; or Z together with R 4 or R 6 may also form a five- or six-membered saturated or unsaturated ring which, in addition to carbon atoms and Y, may comprise one or two further heteroatoms from the group consisting of O, N and S as ring members the groups R 1 to R 7 , Z and R may be substituted according to the description; processes for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic harmful fungi.

    SUBSTITUTED 5-PHENYL PYRIMIDINES I IN THERAPY
    35.
    发明专利
    SUBSTITUTED 5-PHENYL PYRIMIDINES I IN THERAPY 未知

    公开(公告)号：CA2595958A1

    公开(公告)日：2006-08-03

    申请号：CA2595958

    申请日：2006-01-30

    Applicant: BASF AG

    Inventor： RHEINHEIMER JOACHIM ,  MULLER BERND ,  GROTE THOMAS ,  NAVE BARBARA ,  SCHIEWECK FRANK ,  SCHWOGLER ANJA ,  BLETTNER CARSTEN ,  JABS THORSTEN

    IPC: A61K31/506 ,  A61K31/505 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

    Abstract: The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NR 1 R 2 , OR 1a or SR 1a , in which R 1 , R 2 , independently of each other, denote hydrogen, C 1 -C 10 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 10 -haloalkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 ; or the radical NR 1 R 2 may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NR 1 R 2 , in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C 1 -C 4 -alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 as defined in claim 1 , R 1a has one of the meanings given for R 1 except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, C 3 -C 4 -alkenyloxy, C 3 -C 4 -alkynyloxy, C 1 -C 6 -alkylthio, di-(C 1 -C 6 -alkyl)amino or C 1 -C 6 -alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C 1 -C 2 -alkoxy or C 1 -C 4 -alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases.

    Substituted 5-phenyl pyrimidines I in therapy
    36.
    发明专利
    Substituted 5-phenyl pyrimidines I in therapy 未知

    公开(公告)号：AU2006208621A1

    公开(公告)日：2006-08-03

    申请号：AU2006208621

    申请日：2006-01-30

    Applicant: BASF AG

    Inventor： SCHIEWECK FRANK ,  NAVE BARBARA ,  GROTE THOMAS ,  MULLER BERND ,  RHEINHEIMER JOACHIM ,  BLETTNER CARSTEN ,  JABS THORSTEN ,  SCHWOGLER ANJA

    IPC: A61K31/506 ,  A61K31/505 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

    Abstract: The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NR 1 R 2 , OR 1a or SR 1a , in which R 1 , R 2 , independently of each other, denote hydrogen, C 1 -C 10 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 10 -haloalkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 ; or the radical NR 1 R 2 may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NR 1 R 2 , in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C 1 -C 4 -alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 as defined in claim 1 , R 1a has one of the meanings given for R 1 except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, C 3 -C 4 -alkenyloxy, C 3 -C 4 -alkynyloxy, C 1 -C 6 -alkylthio, di-(C 1 -C 6 -alkyl)amino or C 1 -C 6 -alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C 1 -C 2 -alkoxy or C 1 -C 4 -alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases.

    Ion channel forming peptaibols for use as resistance inductors
    38.
    发明专利
    Ion channel forming peptaibols for use as resistance inductors 未知

    公开(公告)号：AU4247101A

    公开(公告)日：2001-09-24

    申请号：AU4247101

    申请日：2001-03-15

    Applicant: BASF AG

    Inventor： JABS THORSTEN ,  AMMERMANN EBERHARD ,  STIERL REINHARD ,  LORENZ GISELA ,  BOLAND WILHELM ,  ENGELBERTH JUERGEN

    IPC: A01N37/46 ,  A01N63/04

    Abstract: Use of ion channel forming compounds (I) is claimed as resistance inducers in plant protection. An independent claim is included for the use of (I) as fungicides in plant protection. - ACTIVITY : Fungicide; antibacterial; virucide; nematocide; insecticide. In tests for systemic activity against Colletotrichum lagenarium in cucumber plants, application of an aqueous preparation comprising alamethicin (Ia) at 10 ppm reduced the degree of infection of leaves from 80% (in controls) to 7%. - MECHANISM OF ACTION : Ion channel former; inducer of intrinsic defense mechanisms of plants; plant secondary metabolism elicitor; tendrils spiralization inducer.

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