公开(公告)号：LU79235A1

公开(公告)日：1978-06-28

申请号：LU79235

申请日：1978-03-15

Applicant: BASF AG

Inventor： PHILIPSBORN G ,  BOELL W ,  LENKE D

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  C07D ,  A61K

公开(公告)号：SE446185B

公开(公告)日：1986-08-18

申请号：SE7802927

申请日：1978-03-14

Applicant: BASF AG

Inventor： VON PHILIPSBORN G ,  BOELL W ,  LENKE D

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：YU225282A

公开(公告)日：1983-02-28

申请号：YU225282

申请日：1982-10-07

Applicant: BASF AG

Inventor： VON PHILIPSBORN G ,  BOELL W ,  LENKE D

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  C07D213/02 ,  C07D213/74

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：YU102179A

公开(公告)日：1983-02-28

申请号：YU102179

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME P ,  FRICKEL F ,  THEOBALD H ,  FRANKE A ,  LENKE D ,  GRIES J

IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08 ,  C07D261/06

Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

公开(公告)号：YU63678A

公开(公告)日：1983-01-21

申请号：YU63678

申请日：1978-03-16

Applicant: BASF AG

Inventor： VON PHILIPSBORN G ,  BOELL W ,  LENKE D

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  C07D213/02 ,  C07D213/74

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：DK145342B

公开(公告)日：1982-11-01

申请号：DK50078

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL F-F ,  HAGEN H ,  OHNSORGE U ,  FRANKE A ,  LENKE D ,  GRIES J ,  LEHMANN H D

IPC: A61K31/428 ,  C07D275/04

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.

公开(公告)号：ZA8103966B

公开(公告)日：1982-07-28

申请号：ZA8103966

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES M ,  FRANKE A ,  KOENIG H ,  LENKE D ,  LEHMANN H ,  GRIES J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  A61K ,  C07C

CPC classification number: C07D237/04

公开(公告)号：DK19182A

公开(公告)日：1982-07-20

申请号：DK19182

申请日：1982-01-18

Applicant: BASF AG

Inventor： THIEME P C ,  STEINER G ,  ROHR W ,  LENKE D ,  GRIES J ,  WEIFENBACH H ,  TESCHENDORF H J ,  HOFMAN H P ,  KREISKOTT H

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  C07D

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：DK19082A

公开(公告)日：1982-07-20

申请号：DK19082

申请日：1982-01-18

Applicant: BASF AG

Inventor： FRANKE A ,  STEINER G ,  THIEME P C ,  LENKE D ,  GRIES J ,  TESCHENDORF H J

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61P9/02 ,  A61P11/08 ,  A61P25/08 ,  A61P25/20 ,  C07D231/12 ,  C07D231/38 ,  C07D233/60 ,  C07D233/88 ,  C07D239/42 ,  C07D261/08 ,  C07D295/06 ,  C07D295/092 ,  C07D521/00 ,  C07D

Abstract: Novel (hetarylphenoxy)-(phenylpiperazinyl)-propanols of the formula I where R1 is hydrogen, amino or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, and the heterocyclic structure Het. is pyrimidinyl, triazol-1-yl, imidazol-1-yl, pyrazol-3-yl or isoxazol-3-yl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly hypotensive, sedative, neuroleptic and broncholytic properties.

公开(公告)号：ZA811503B

公开(公告)日：1982-04-28

申请号：ZA811503

申请日：1981-03-06

Applicant: BASF AG

Inventor： STEINER G ,  HOFMANN H ,  KREISKOTT H ,  TESCHENDORF H ,  LENKE D

IPC: A61K31/275 ,  A61K31/395 ,  C07D295/14 ,  A61K31/50 ,  A61K31/55 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155 ,  A61K ,  C07D

Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.