公开(公告)号：DE19539360A1

公开(公告)日：1997-04-24

申请号：DE19539360

申请日：1995-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/19

Abstract: The invention concerns a method of producing medicaments in solid form by mixing at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives, extruding the mixture and shaping the medicament, a pre-mixture being prepared from the components and fed into the extruder. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.

公开(公告)号：DE19536387A1

公开(公告)日：1997-04-03

申请号：DE19536387

申请日：1995-09-29

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  BREITENBACH JOERG DR

IPC: A61K9/20 ,  A61K47/38 ,  A61J3/06

Abstract: A process for preparing vitamin-containing pharmaceutical products by extruding then moulding a vitamin-containing molten polymer is characterised in that a hydroxypropyl cellulose is used as matrix polymer.

公开(公告)号：DE19504832A1

公开(公告)日：1996-08-22

申请号：DE19504832

申请日：1995-02-14

Applicant: BASF AG

Inventor： GRABOWSKI SVEN DR ,  BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR

IPC: A61K9/22 ,  A61K9/20 ,  A61K47/38 ,  A61K47/30

Abstract: Solid preparations obtainable by the melt extrusion of A) at least one active agent, B) a mixture of B1) 10 to 90 wt.% of a water-soluble, thermoplastic polymer and B2) 10 to 90 wt.% of a low-substituted hydroxypropyl cellulose and C) 0 to 50 wt.% in relation to the total quantity of the preparation of common pharmaceutical auxiliaries.

公开(公告)号：ES2140428T3

公开(公告)日：2000-03-01

申请号：ES93112464

申请日：1993-08-04

Applicant: BASF AG

Inventor： GRABOWSKI SVEN DR ,  SANNER AXEL DR ,  ROSENBERG JOERG DR

IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.

公开(公告)号：DE19754873A1

公开(公告)日：1999-06-17

申请号：DE19754873

申请日：1997-12-10

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  KLEINKE ANDREAS DR ,  FARWERCK KARL-PETER ,  JOCHUM ALFONS ,  LANGE ARMIN DR ,  KRULL HARALD ,  ROSENBERG JOERG DR ,  MAIER WERNER ,  JOTTER KARL LUDWIG ,  TRAPP BURKHARD DR

IPC: A61K9/16 ,  B01J2/20 ,  B29B9/06 ,  B30B9/28 ,  B30B11/22 ,  C05G3/00 ,  B29C47/58 ,  B29B9/10 ,  B29C47/30 ,  B29C47/60

Abstract: The invention relates to an extrusion device, particularly an extrusion device for thermoplastic or dough-like masses or highly tenacious melts, and to the use of said device. The extrusion device has a housing (11), at least one conveyor worm (12) arranged in a housing and an outlet (20) disposed on the front face of the housing (11) close to the end of each conveyor screw which is furthest away from the drive end. At least one stripping member (21) is arranged in between the end (14) of each conveyor screw (12) furthest away from the drive end and the outlet (20). The device is particularly suitable for producing granulates, preferably those containing active substances.

公开(公告)号：CZ187197A3

公开(公告)日：1998-05-13

申请号：CZ187197

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  FRICKE HELMUT DR ,  BREITENBACH JORG DR

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：CZ9702802A3

公开(公告)日：1998-03-18

申请号：CZ280297

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  SANNER AXEL DR ,  ROSENBERG JOERG DR

IPC: A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30 ,  A61K9/00

CPC classification number: A61K31/192 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2095

公开(公告)号：CZ9701851A3

公开(公告)日：1998-03-18

申请号：CZ185197

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  BREITENBACH JORG DR

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/2072 ,  B30B11/165

公开(公告)号：CZ9603405A3

公开(公告)日：1997-06-11

申请号：CZ340596

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  BREITENBACH JORG DR

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

CPC classification number: A61K9/2013 ,  A61K9/146 ,  A61K9/2027 ,  A61K9/2095 ,  B01J2/20

公开(公告)号：DE19539362A1

公开(公告)日：1997-04-24

申请号：DE19539362

申请日：1995-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  MAIER WERNER ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/24

Abstract: The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping this mixture to form the desired medicament, the mixing, melting and shaping steps being carried out continuously and separately. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.