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    HIGH AFFINITY ANTIBODIES TO SMALL PEPTIDES
    32.
    发明申请
    HIGH AFFINITY ANTIBODIES TO SMALL PEPTIDES 审中-公开
    对小肽的高亲和力抗体

    公开(公告)号：WO1991017177A1

    公开(公告)日：1991-11-14

    申请号：PCT/US1991003009

    申请日：1991-05-02

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  BETHELL, Delia, R. ,  JOLLEY, Michael, E. ,  STEVENS, Priscilla, Wilkins

    IPC: C07K01/00

    CPC classification number: C07K1/00 ,  C07K16/00

    Abstract: High affinity antibodies to small peptides or small peptide epitopes within proteins are prepared by substituting selected amino acids within the antigen combining site which enhance antigen binding affinity. The amino acid substitutions are selected by molecular modelling techniques involving dynamic analysis of the native and substituted structures.

    Abstract translation: 通过在增强抗原结合亲和力的抗原结合位点内取代选定的氨基酸来制备蛋白质内的小肽或小肽表位的高亲和力抗体。 通过涉及天然和取代结构的动态分析的分子模拟技术来选择氨基酸取代。

    ANALYSIS SYSTEM AND COMPONENTS
    33.
    发明申请
    ANALYSIS SYSTEM AND COMPONENTS 审中-公开
    分析系统和组件

    公开(公告)号：WO1995002816A1

    公开(公告)日：1995-01-26

    申请号：PCT/US1994007509

    申请日：1994-07-06

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  CORMIER, Alan, D. ,  WEINBERG, Melvin, S. ,  JONES, Ronald, L. ,  VITIELLO, Janet, D.

    IPC: G01N27/28

    CPC classification number: G01N33/492 ,  G01N33/4915

    Abstract: The present invention provides sensing electrodes and electrode assemblies for use in measuring the activity of ions in a fluid sample; measuring blocks which include a sensing module housing such sensing electrodes and a reference electrode; and a fluid analysis system which includes such measuring blocks.

    Abstract translation: 本发明提供了用于测量流体样品中离子的活性的感测电极和电极组件; 测量块，其包括容纳这种感测电极和参考电极的感测模块; 以及包括这种测量块的流体分析系统。

    FLUID DISPENSING APPARATUS AND METHOD
    34.
    发明申请
    FLUID DISPENSING APPARATUS AND METHOD 审中-公开
    流体分配装置

    公开(公告)号：WO1995002190A1

    公开(公告)日：1995-01-19

    申请号：PCT/US1994007506

    申请日：1994-07-06

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  JONES, Donald

    IPC: G01N35/00

    CPC classification number: G01N35/0099 ,  G01N35/1002 ,  Y10T436/11 ,  Y10T436/113332

    Abstract: A chemical analyser (10) includes a fluid dispensing system (46) with a carrier member (18) and fluid dispensing head (72). The carrier member (18) includes a docking fixture (52) and the fluid dispensing head includes a docking receptacle (54). By engagment of the docking fixture and receptacle the carrier member carries the fluid dispensing head to a position above a recess (34) into which fluid is precisely dispensed. The carrier member also returns the fluid dispensing head to a storage location (64) substantially separating the fluids to be dispensed from the environment of the analyzer. When the fluid dispensing head is in its storage location the carrier member may disengage to perform other functions in the analyzer.

    Abstract translation: 化学分析器（10）包括具有载体构件（18）和流体分配头（72）的流体分配系统（46）。 承载构件（18）包括对接固定件（52），并且流体分配头包括对接插座（54）。 通过接合对接固定件和容器，承载构件将流体分配头运送到凹槽（34）上方的位置，精确地分配流体。 载体构件还将流体分配头返回到基本上将待分配的流体与分析器的环境分离的存储位置（64）。 当流体分配头处于其存储位置时，承载构件可以脱离以在分析器中执行其它功能。

    AUTOMATED CHEMICAL ANALYZER WITH APPARATUS AND METHOD FOR CONVEYING AND TEMPORARY STORAGE OF SAMPLE TUBES
    35.
    发明申请
    AUTOMATED CHEMICAL ANALYZER WITH APPARATUS AND METHOD FOR CONVEYING AND TEMPORARY STORAGE OF SAMPLE TUBES 审中-公开
    自动化学分析仪，用于输送和临时存储样品管的方法

    公开(公告)号：WO1995000854A1

    公开(公告)日：1995-01-05

    申请号：PCT/US1994007255

    申请日：1994-06-28

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  MAZZA, John, C. ,  STARK, William, A ,  SCRIBNER, Richard, A. ,  FRYE, Stephen, L. ,  HARDIMAN, Kempton, H.

    IPC: G01N35/04

    CPC classification number: B01L3/50855 ,  B01L9/06 ,  G01N35/04 ,  G01N2035/00752 ,  G01N2035/0406

    Abstract: An automated chemical analyzer (8) includes an automated conveyor apparatus (10) for receiving a variety of sizes of test tubes, cuvettes, and sample tubes in a standard carrier member (16) receivable into the analyzer. The standard carrier members may be interlocked in ranks and placed side by side in file to replicate the size and handling convenience of conventional test tube racks. However, the conveyor apparatus also provides for receipt of the carriers either as individuals for stat handling (14), or in interlocked ranks, or as rank and file groups for routine handling (20). The interlocked ranks of carriers are automatically unlocked from one another and fed along with the carriers having stat samples therein to a recirculating endless loop conveyor device (34) which conveys the samples to at least one chemical analysis module (40), as well as providing a storage capacity both for samples in testing, and those samples awaiting verification of test results. Carriers with samples on which testing is completed and verified are discharged from the endless loop conveyor device into an off-loading facility (52-58) which again interlocks the carriers and presents them in rank and file groups for subsequent handling like conventional test tube racks.

    Abstract translation: 一种自动化学分析仪（8）包括用于在可接收到分析器中的标准载体构件（16）中接收各种尺寸的试管，比色皿和样品管的自动输送装置（10）。 标准载体构件可以排列成并排放置，以复制常规试管架的尺寸和操作方便性。 然而，传送装置还提供作为用于统计处理的个人（14）或联锁队列的个人或作为例行处理（20）的排名和文件组的接收者。 互锁的载体排自动地彼此解锁并与其中具有状态样本的载体一起供给到循环无端环输送装置（34），该输送装置将样品输送到至少一个化学分析模块（40），以及提供 测试样品的存储容量，以及等待验证测试结果的样品。 测试完成和验证的样品的载体从无端循环输送装置排出到卸载设备（52-58）中，该卸载设备（52-58）再次使载体互锁，并将它们以级别和文件组提供，以便随后处理，如常规试管架 。

    A DNA SEQUENCE AND ENCODED POLYPEPTIDE USEFUL IN THE DIAGNOSIS OF HEPATITIS DISEASE
    38.
    发明申请
    A DNA SEQUENCE AND ENCODED POLYPEPTIDE USEFUL IN THE DIAGNOSIS OF HEPATITIS DISEASE 审中-公开
    DNA序列和编码的多肽在肝炎病毒诊断中的应用

    公开(公告)号：WO1993015111A1

    公开(公告)日：1993-08-05

    申请号：PCT/US1993000927

    申请日：1993-02-03

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  RYAN, Terence, E. ,  SAEED, Badr ,  KIESELBURG, Mark, K. ,  BYRNE, Robert, E. ,  STEVENS, Priscilla, Wilkins ,  ARIMA, Terukatsu ,  TODD, John, A.

    IPC: C07K07/10

    CPC classification number: G01N33/5767 ,  A61K39/00 ,  C07K14/005 ,  C12N2770/24222 ,  C12Q1/707 ,  Y10S436/82

    Abstract: A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A, non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.

    Abstract translation: 已经分离了一种新的cDNA克隆20E，并将其表征为编码在某些非A非乙型肝炎（NANBH）患者的血清中被抗体识别的先前未知的多肽抗原。 核酸序列不在丙型肝炎病毒（HCV）的基因组中表示。 核酸序列也不在人类基因组中表示。 数据表明，对应于克隆20E的RNA序列被包含在HCV以外的外部感染因子的基因组中，因此可能代表另外的病原体或人类患者中NANBH发展的促成因子。 20E核酸和相应的多肽及其相应变体可用于针对NANBH的预防和诊断的多种方法。

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