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    Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation
    32.
    发明专利
    Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation 未知

    公开(公告)号：AU3300901A

    公开(公告)日：2001-08-07

    申请号：AU3300901

    申请日：2001-01-26

    Applicant: BAXTER INT

    Inventor： WOO LECON ,  BOGGS DANIEL R ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

    IPC: A61L2/00 ,  A61L2/10 ,  A61M1/02 ,  A61M1/36 ,  A61L2/02

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

    38.
    发明专利
    未知

    公开(公告)号：DE60141509D1

    公开(公告)日：2010-04-22

    申请号：DE60141509

    申请日：2001-01-26

    Applicant: BAXTER INT

    Inventor： WOO LECON ,  BOGGS DANIEL R ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

    IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61M1/02 ,  A61M1/36

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION
    39.
    发明专利
    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION 未知

    公开(公告)号：CA2398247C

    公开(公告)日：2008-12-02

    申请号：CA2398247

    申请日：2001-01-26

    Applicant: BAXTER INT

    Inventor： STERNBERG SHMUEL ,  SANDFORD CRAIG ,  BOGGS DANIEL R ,  WOO LECON ,  BREILLATT JULIAN ,  KHARE ATUL

    IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61L2/08 ,  A61M1/02 ,  A61M1/36

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to th e radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows throughthe belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

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