公开(公告)号：AU2014274766A1

公开(公告)日：2015-12-10

申请号：AU2014274766

申请日：2014-06-06

Applicant: BAXTER HEALTHCARE SA ,  UNIV NORTHWESTERN ,  BAXTER INT

Inventor： HAI TON THAT ,  GREEN JOHN-BRUCE DEVAULT ,  FULGHUM TIMOTHY MICHAEL ,  MESSERSMITH PHILLIP BYRON ,  SILEIKA TADAS STANISLOVAS

IPC: A61L27/00 ,  G01N33/543 ,  G01N33/551

Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：CA2658133C

公开(公告)日：2015-11-24

申请号：CA2658133

申请日：2007-07-20

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： LURVEY KENT L ,  KRONGAUZ VADIM V ,  YEH ROSA H ,  PAULEY ROBIN G ,  CAWTHON DUSTIN C ,  HAI TON THAT ,  WOO LECON L ,  KHANNA ASHOK K ,  LAL BIRENDRA K ,  LING MICHAEL TUNG-KIUNG ,  HOERLE WILLIAM S ,  SANDFORD CRAIG L ,  NORDHAUS MARK A ,  SAVITSKI ALEXANDER ,  KIRICHKOW NICKLAUS J ,  SUH KENNETH GLEN ,  KRISHNAMOORTHY SIVARAMAKRISHNAN ,  YANG HSINJIN E ,  CLARKE ROBERT A ,  STERNBERG SHMUEL

IPC: A61M39/16

Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

公开(公告)号：AU2014239600A1

公开(公告)日：2015-09-24

申请号：AU2014239600

申请日：2014-03-14

Applicant: BAXTER INT ,  UNIV NORTHWESTERN ,  BAXTER HEALTHCARE SA

Inventor： HAI TON THAT ,  GREEN JOHN-BRUCE DEVAULT ,  FULGHUM TIMOTHY MICHAEL ,  MESSERSMITH PHILLIP BYRON ,  SILEIKA TADAS STANISLOVAS

IPC: A61L27/54 ,  A61L29/16 ,  A61L31/16

Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：NZ591045A

公开(公告)日：2013-01-25

申请号：NZ59104509

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SANDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: A61K47/48 ,  A61P7/00

Abstract: Disclosed is a compound of Formula I e.g. 4-(((2,5-dioxopyrrolidin-1-yloxy)carbonyloxy )methyl)phenyl 4-(2-methoxypolyethoxy)-2-methylbutanoate wherein the substituents are defined in the specification.

公开(公告)号：MX2007000742A

公开(公告)日：2007-03-30

申请号：MX2007000742

申请日：2005-06-22

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  NORDHAUS MARK ,  SANDERS PAUL ,  JIANG CONG ,  KAROOR SUJATHA ,  MELNICK BEN

IPC: A61P39/06 ,  A61K31/355

Abstract: Se proveen composiciones terapeuticas. Las composiciones incluyen una molecula unica que puede exhibir propiedades secuestrantes y antioxidantes de carbonilo. Esto puede reducir efectivamente la inflamacion, el estres oxidativo y el estres de carbonilo, a fin de prevenir y/o tratar la enfermedad cardiovascular y las enfermedades inflamatorias en pacientes con enfermedades renales.

公开(公告)号：AU2002353814A1

公开(公告)日：2004-05-04

申请号：AU2002353814

申请日：2002-10-15

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  MARKOSKI LARRY J

IPC: A61K47/48 ,  C08G65/325 ,  C08G65/329 ,  C08G65/334 ,  C08G65/337

公开(公告)号：ZA988662B

公开(公告)日：1999-03-31

申请号：ZA988662

申请日：1998-09-22

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  NELSON DEANNA J ,  PEREIRA DAVID E

IPC: A61K38/42 ,  A61K

公开(公告)号：AU8158698A

公开(公告)日：1999-02-10

申请号：AU8158698

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  PEREIRA DAVID E ,  NELSON DEANNA J

IPC: A61K38/16 ,  A61K38/00 ,  A61P7/00 ,  A61P43/00 ,  C07G3/00 ,  C07K14/805 ,  C08B37/00 ,  C08G63/48 ,  A61K35/14 ,  A61K39/385 ,  C07H1/00

Abstract: Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.

公开(公告)号：ES2091940T3

公开(公告)日：1996-11-16

申请号：ES91914918

申请日：1991-08-15

Applicant: BAXTER INT

Inventor： NELSON DEANNA J ,  HAI TON THAT ,  SRNAK ANA

IPC: A61K38/16 ,  A61K38/00 ,  A61P7/08 ,  C07K14/805 ,  A61K38/42 ,  C07K2/00 ,  C07K4/00 ,  C07K14/00 ,  C07K16/00

公开(公告)号：CA2914732C

公开(公告)日：2019-06-25

申请号：CA2914732

申请日：2014-06-06

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  UNIV NORTHWESTERN

Inventor： HAI TON THAT ,  GREEN JOHN-BRUCE DEVAULT ,  FULGHUM TIMOTHY MICHAEL ,  MESSERSMITH PHILLIP BYRON ,  SILEIKA TADAS STANISLOVAS

IPC: A61L27/00 ,  G01N33/543 ,  G01N33/551

Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.