公开(公告)号：CA2360013A1

公开(公告)日：2000-07-20

申请号：CA2360013

申请日：2000-01-18

Applicant: CALIPER TECHN CORP

Inventor： CHOW ANDREA W ,  KOPF-SILL ANNE R

IPC: G01N31/20 ,  C12Q1/25 ,  C12Q1/68 ,  C12Q1/6813 ,  G01N27/447 ,  G01N33/53 ,  G01N33/566 ,  G01N35/08 ,  C12Q1/00 ,  G01N33/567

Abstract: Throughput rates for microfluidic serial analysis systems are optimized by maximizing the proximity and speed with which multiple different samples may be serially introduced into a microfluidic channel network. Devices are included that include optimized parameters based upon desired throughput rat es for a given set of reagents, reaction times and the like.

公开(公告)号：NZ333346A

公开(公告)日：2000-03-27

申请号：NZ33334697

申请日：1997-06-24

Applicant: CALIPER TECHN CORP

Inventor： PARCE JOHN WALLACE ,  KOPF-SILL ANNE R ,  BOUSSE LUC J

IPC: G01N31/20 ,  B01J19/00 ,  B01L3/00 ,  C12Q1/04 ,  C12Q1/25 ,  G01N27/26 ,  G01N27/27 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574 ,  G01N35/08 ,  G01N37/00 ,  C12Q1/68

Abstract: An apparatus for screening test compounds for an effect on a biochemical system comprising: a).a body having at least two intersecting channels fabricated therein, at least one of said at least two intersecting channels having at least one cross-sectional dimension in the range from about 0.1 to about 500mm b).a source of different test compounds fluidly connected to a first of at least two intersecting channels c).at least one component of said biochemical system fluidly connected to a second of the two intersecting channels d).a fluid direction system for flowing said at least one component within the second of said two intersecting channels and for introducing the different test compounds from the first to the second of the two intersecting channels and e).a detecting zone in said second channel for detecting an effect of the test compound on the biochemical system. Also claimed is the method for detecting the test compounds.

公开(公告)号：CA2284612A1

公开(公告)日：1998-10-15

申请号：CA2284612

申请日：1998-04-03

Applicant: CALIPER TECHN CORP

Inventor： BOUSSE LUC J ,  KOPF-SILL ANNE R ,  PARCE JOHN WALLACE ,  KNAPP MICHAEL

IPC: G01N33/50 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  C07H21/04 ,  C12M1/00 ,  C12N15/09 ,  C12P19/34 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/447 ,  G01N35/10 ,  C12N15/00 ,  G01N21/00 ,  C07H21/02 ,  C12N11/04 ,  G01N15/06

Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.

公开(公告)号：AU2005234635A1

公开(公告)日：2005-12-08

申请号：AU2005234635

申请日：2005-11-16

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  PARCE JOHN WALLACE ,  BOUSSE LUC J

IPC: B01J19/00 ,  C12Q1/68

公开(公告)号：AU2003213516B2

公开(公告)日：2005-09-01

申请号：AU2003213516

申请日：2003-07-17

Applicant: CALIPER TECHN CORP

Inventor： BOUSSE LUC J ,  KOPF-SILL ANNE R ,  PARCE JOHN WALLACE

IPC: B01J19/00 ,  C12Q1/68 ,  B01J019/00 ,  C12Q001/68

公开(公告)号：AU770678B2

公开(公告)日：2004-02-26

申请号：AU5015800

申请日：2000-05-11

Applicant: CALIPER TECHN CORP

Inventor： WADA H GARRETT ,  KOPF-SILL ANNE R ,  ALAJOKI MARJA LIISA ,  PARCE J WALLACE ,  WANG BENJAMIN N ,  CHOW ANDREA W ,  DUBROW ROBERT S

IPC: B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N1/40 ,  G01N15/14 ,  G01N27/447 ,  C12Q1/00

Abstract: Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.

公开(公告)号：CA2304572C

公开(公告)日：2004-01-06

申请号：CA2304572

申请日：1998-10-07

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  PARCE WALLACE J

IPC: B01J19/00 ,  B01L3/00 ,  G01N27/447 ,  B81B1/00

Abstract: The present invention is generally directed to improved microfluidic devices (100), systems, and methods of using the same. In particular, the device and systems employ channels (408, 512) having, at least in part, depths that are varied to provide advantageous effects upon the flow rate of fluids in the channel. Typically, microscale channel (408, 512) has an aspect ratio (width/depth) less than or equal to about 1. Variation of the channel depth (408, 512) may be optimized depending upon the nature of the materials to be mixed.

公开(公告)号：AU747713B2

公开(公告)日：2002-05-23

申请号：AU7175500

申请日：2000-11-22

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

IPC: G01N27/26 ,  G01N27/447 ,  G01N33/53 ,  G01N33/557

公开(公告)号：CA2406704A1

公开(公告)日：2001-10-04

申请号：CA2406704

申请日：2001-03-22

Applicant: CALIPER TECHN CORP

Inventor： JANN PETER C ,  JENSEN MORTEN J ,  KENNEDY MICHAEL ,  KENNEDY COLIN B ,  SPAID MICHAEL ,  KOPF-SILL ANNE R ,  CHOW ANDREA W

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  G01N27/26

Abstract: Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides a cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.

公开(公告)号：AU730827B2

公开(公告)日：2001-03-15

申请号：AU7832198

申请日：1998-06-08

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

IPC: B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  G01N27/447 ,  G01N33/557 ,  C12Q1/70

Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.