公开(公告)号：WO1996036860A3

公开(公告)日：1996-11-21

申请号：PCT/US1996006017

申请日：1996-04-30

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  PANESCU, Dorin ,  SWANSON, David, K. ,  FLEISCHMAN, Sidney, D. ,  BOURNE, Thomas, M. ,  WHAYNE, James, G.

IPC: A61B17/39

公开(公告)号：WO1996025096A1

公开(公告)日：1996-08-22

申请号：PCT/US1996002092

申请日：1996-02-16

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K. ,  WHAYNE, James, G. ,  PANESCU, Dorin

IPC: A61B05/0402

CPC classification number: A61N1/056 ,  A61B1/0051 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/6855 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2562/0209 ,  A61B2562/043

Abstract: Systems and methods acquire electrocardiograms using a first electrode (24) associated with a region of heart tissue and a second body surface electrode. An analog or digital processing element (32) is coupled to the first and second electrodes for conditioning the first electrode to emit a pacing signal (48) and for conditioning the second electrode to sense paced electrocardiograms occurring as a result of the pacing signal. The systems and methods also employ a template of an electrocardiogram of a cardiac event of known diagnosis; for example an arrhythmia that the physician seeks to treat. The systems and methods compare this event-specific template to a sample of a paced electrocardiogram. The comparison yields a matching coefficient indicating how alike the input sample is to the input template. The matching coefficient can be used by the physician, for example to aid in the location of sites that are potentially appropriate for ablation (46).

Abstract translation: 系统和方法使用与心脏组织区域和第二体表电极相关联的第一电极（24）获取心电图。 模拟或数字处理元件（32）耦合到第一和第二电极，用于调节第一电极以发出起搏信号（48），并用于调节第二电极以感测由于起搏信号而产生的起搏心电图。 系统和方法还采用已知诊断的心脏事件的心电图的模板; 例如医师寻求治疗的心律失常。 系统和方法将此事件特定的模板与起搏心电图的样本进行比较。 比较产生一个表示输入样本与输入模板相似度的匹配系数。 匹配系数可由医生使用，例如帮助位置可能适合消融的位置（46​​）。

公开(公告)号：WO1996014891A1

公开(公告)日：1996-05-23

申请号：PCT/US1995013369

申请日：1995-10-17

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  THOMPSON, Russell, B. ,  McGEE, David

IPC: A61M05/00

CPC classification number: A61M25/00 ,  A61M2025/0008 ,  A61M2205/6063

Abstract: This invention is a catheter assembly (10) which has a distal end adapted for insertion into a living body, and a proximal end adapted to remain external to said body, or a cable for use in such an assembly that includes a cylindrical surface on which is inscribed a plurality of markings (16). Each of the markings indicates one of the specific locations within the living body at which the distal end may be placed during insertion. The markings are positioned at spaced intervals around the circumference of the cylindrical surface. A sleeve (18) is rotatably and/or axially movable around the cylindrical surface, the sleeve being provided with at least one window (20) adapted to be moved into alignment with a selected one of the markings.

Abstract translation: 本发明是一种导管组件（10），其具有适于插入生物体的远端和适于保持在所述主体外部的近端，或用于这种组件的电缆，该组件包括圆柱形表面 刻有多个标记（16）。 每个标记表示插入期间可以放置远端的活体内的特定位置之一。 标记围绕圆柱形表面的圆周以间隔的间隔定位。 套筒（18）围绕圆柱形表面可旋转和/或轴向移动，套筒设置有至少一个窗口（20），该窗口适于移动成与选定的一个标记对齐。

公开(公告)号：WO1995020349A1

公开(公告)日：1995-08-03

申请号：PCT/US1995001123

申请日：1995-01-27

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  PANESCU, Dorin ,  SWANSON, David, K.

IPC: A61B05/04

CPC classification number: A61B5/6855 ,  A61B5/05 ,  A61B5/0538 ,  A61B5/6858

Abstract: This invention is systems and methods to examine heart tissue morphology using three or more spaced apart electrodes (38), at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical currents (64) through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods (206) also sense the timing of local depolarization events in the tissue in which impedance is sensed, and derive therefrom the propagation velocities of the sensed depolarization events.

Abstract translation: 本发明是使用三个或更多个间隔开的电极（38）检查心脏组织形态的系统和方法，其中至少两个电极位于心脏内与心内膜组织接触。 系统和方法通过位于选择的电极对之间的心脏组织的区域传输电流（64），每对中的至少一个电极位于心脏内。 系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。 系统和方法（206）还感测在其中感测阻抗的组织中的局部去极化事件的定时，并从其导出感测的去极化事件的传播速度。

公开(公告)号：WO1995010979A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011740

申请日：1994-10-14

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  KUCK, Karl-Heinz ,  THOMPSON, Russell, B.

IPC: A61B05/0452

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2018/1497 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/046

Abstract: A multiple electrode array (18) senses electrical events in heart tissue at different orientations in a localized region. First, second, and third electrode elements (60, 62, 64) are spaced apart along different axes. The electrodes (60, 62, 64) are electrically isolated from each other. The spaced apart and electrically isolated electrodes (60, 62, 64) sense multiple bipolar signals measured along the different axes. The electrode array (18) can, without changing position, continuously record multiple electrical events at different relative orientations within a localized area. The spacing and orientation of electrodes on the array (18) permit the physician to detect a small volume signal (like one associated with an accessory pathway), and to differentiate it from nearby large volume signals (like those associated with atrial and ventricular potentials).

Abstract translation: 多电极阵列（18）以局部区域中的不同取向感测心脏组织中的电事件。 第一，第二和第三电极元件（60,62,64）沿着不同的轴线间隔开。 电极（60,62,64）彼此电隔离。 间隔开和电隔离的电极（60,62,64）感测沿着不同轴测量的多个双极信号。 电极阵列（18）可以在不改变位置的情况下连续记录局部区域内的不同相对取向的多个电气事件。 阵列（18）上的电极的间距和取向允许医生检测小体积信号（如与附件通路相关联的信号），并将其与附近的大体积信号（如与心房和心室电位相关的信号）区分开来， 。

公开(公告)号：WO1994007413A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009091

申请日：1993-09-24

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  HOUSER, Russell, A. ,  EDWARDS, Stuart, D. ,  KORDIS, Thomas, F.

IPC: A61B05/0402

CPC classification number: A61B5/6852 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0091 ,  A61B2018/1861 ,  A61B2218/002 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056

Abstract: A system and method for cardiac diagnosis and treatment inserts the distal end of a catheter (18) into a heart chamber. The distal end of the catheter (18) supports at least one electrode (22). The catheter (18) has a fluid flow conduit (62) extending through it. The conduit (62) has a valve (156) that prevents fluid flow from the heart chamber into the conduit (62) in response to in vivo pressure generated during heart systole and diastole. The valve (156) permits fluid flow from the conduit (62) into the heart at a pressure above the in vivo pressure. In use, the catheter (18) locates the electrode (22) in contact with a portion of the endocardium, and fluid is conducted from an external source through the conduit (62) at a pressure above the in vivo pressure to flush the area surrounding the electrode (22).

Abstract translation: 用于心脏诊断和治疗的系统和方法将导管（18）的远端插入心室。 导管（18）的远端支撑至少一个电极（22）。 导管（18）具有延伸通过其的流体流动导管（62）。 导管（62）具有阀（156），其响应于在心脏收缩和舒张期期间产生的体内压力而阻止流体从心室流入导管（62）。 阀（156）允许流体在高于体内压力的压力下从导管（62）流入心脏。 在使用中，导管（18）将电极（22）定位成与心内膜的一部分接触，并且流体在高于体内压力的压力下从外部源通过导管（62）传导以冲洗周围的区域 电极（22）。

公开(公告)号：WO1993008757A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009557

申请日：1992-11-05

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  EDWARDS, Stuart, D. ,  STERN, Roger, A.

IPC: A61B17/39

CPC classification number: A61B18/1206 ,  A61B2017/00101 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00779 ,  A61B2018/00827 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00892

Abstract: Systems (10) for ablating tissue measure the current and voltage delivered to the associated electrode assembly (16) and generate measured current and voltage signals. The systems (10) divide the measured voltage signal by the measured current signal to derive a measured tissue impedance signal. The systems (10) perform control functions based upon the measured tissue impedance signal.

Abstract translation: 用于烧蚀组织的系统（10）测量传递到相关联的电极组件（16）的电流和电压并产生测量的电流和电压信号。 系统（10）将所测量的电压信号除以测量的电流信号，以导出测得的组织阻抗信号。 系统（10）基于所测量的组织阻抗信号执行控制功能。

公开(公告)号：WO1992021278A1

公开(公告)日：1992-12-10

申请号：PCT/US1992004315

申请日：1992-05-22

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  EDWARDS, Stuart, D. ,  FRANZ, Michael, R. ,  THOMPSON, Russell, B. ,  STERN, Roger, A.

IPC: A61B05/04

CPC classification number: A61B18/1206 ,  A61B5/0422 ,  A61B18/12 ,  A61B18/1492 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2017/00473 ,  A61B2018/00107 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/0066 ,  A61B2018/00839 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1495 ,  A61B2018/1497 ,  A61B2018/162 ,  A61B2562/0215 ,  A61N1/056

Abstract: A combination catheter for both detecting monophasic action potentials and ablating surface tissue in an in vivo heart of a patient is provided. The apparatus includes a catheter probe having a terminal tip portion (10) and an electrode (20) carried on the tip such that a portion of the tip electrode (20) is exposed to ambient. A reference electrode (50) is spaced along the tip from the first electrode for supplying a reference potential signal. An ablating electrode (30) is located adjacent to but electrically insulated from both the tip (20) and reference (50) electrodes for providing electromagnetic energy to the tip. The electrodes are electrically connected to the proximal end of the catheter through individual conductors or wires (22, 32 and 50) that run through an insulated cable. An electronic filter is provided to permit the recording of MAPs during ablation without radiofrequency interference. The catheter may also include standard mapping and/or pacing electrodes (80) and (75) respectively. The catheter may further include a steering mechanism for positioning the catheter at various treatment sites in the heart, and a structure for holding the tip electrode in substantially perpendicular contact with heart tissue with a positive pressure, and for spacing the reference electrode from the heart tissue.

Abstract translation: 提供了用于检测患者的体内心脏中的单相动作电位和消融表面组织的组合导管。 该装置包括导管探头，其具有端子末端部分（10）和承载在尖端上的电极（20），使得尖端电极（20）的一部分暴露于环境中。 参考电极（50）沿着尖端与第一电极间隔开，用于提供参考电位信号。 烧蚀电极（30）位于与尖端（20）和参考电极（50）电极相邻但电绝缘的位置，用于向尖端提供电磁能。 电极通过穿过绝缘电缆的各个导体或导线（22,32和50）电连接到导管的近端。 提供电子滤波器以允许在消融期间MAP的记录而没有射频干扰。 导管还可以分别包括标准贴图和/或起搏电极（80）和（75）。 导管还可以包括用于将导管定位在心脏中的各种治疗部位的转向机构，以及用于将尖端电极与正常压力基本上垂直接触心脏组织并将参考电极与心脏组织间隔开的结构 。

公开(公告)号：WO1998026724A1

公开(公告)日：1998-06-25

申请号：PCT/US1997022997

申请日：1997-12-11

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  WHAYNE, James, G.

IPC: A61B17/36

CPC classification number: A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00065 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2218/002 ,  A61M25/0144 ,  A61M25/0147 ,  A61M2025/0163

Abstract: A catheter assembly comprises a first branch (44) having a first axis, a second branch (32) extending in a non-parallel relationship with respect to the first axis and at least one electrode (28) carried by the second branch body (32). In use, the first branch body (44) can be located within a pulmonary vein within the left atrium, while the electrode (28) carried by the second branch body (32) is located in contact with endocardial tissue outside the pulmonary vein. Ablation energy can be transmitted from the electrode (28) to contacted endocardial tissue while the first branch (44) body is located within the pulmonary vein.

Abstract translation: 导管组件包括具有第一轴线的第一分支（44）和相对于第一轴线以非平行关系延伸的第二分支（32）和由第二分支体（32）承载的至少一个电极（28） ）。 在使用中，第一分支体（44）可以位于左心房内的肺静脉内，而由第二分支体（32）承载的电极（28）位于与肺静脉外的心内膜组织接触。 当第一分支（44）体位于肺静脉内时，消融能量可以从电极（28）传递到接触心内膜组织。

公开(公告)号：WO1998018388A1

公开(公告)日：1998-05-07

申请号：PCT/US1997019373

申请日：1997-10-27

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  McGEE, David ,  SWANSON, David, K. ,  TENHOFF, Harm ,  PANESCU, Dorin ,  WHAYNE, James, G.

IPC: A61B08/12

CPC classification number: A61B8/12 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7285 ,  A61B6/541 ,  A61B8/4461 ,  A61B8/4488 ,  A61B8/543 ,  A61B18/1492 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/1861

Abstract: An imaging element characterizes tissue morphology by analyzing perfusion patterns of a contrast media in tissue visualized by the imaging element, to identify infarcted tissue. In a preferred implementation, a catheter tube (12) introduced into a heart region carries the imaging element (34), as well as a support structure (20) spaced from the imaging element, which contracts endocardial tissues. The imaging element is moved as the imaging element visualizes tissue. A selected electrical event is sensed in surrounding myocardial tissue which regulates movement of the imaging element. The support element stabilizes the moving imaging element as it visualizes tissue, providing resistance to dislodgment or disorientation despite the presence of dynamic forces.

Abstract translation: 成像元件通过分析由成像元件可视化的组织中的造影剂的灌注模式来表征组织形态，以鉴定梗死组织。 在优选的实施方案中，引入心脏区域的导管（12）携带成像元件（34）以及与成像元件间隔开的支架结构（20），其收缩心内膜组织。 当成像元件可视化组织时，成像元件移动。 在周围的心肌组织中感测出选择的电子事件，其调节成像元件的运动。 支撑元件在移动成像元件可视化组织时稳定运动成像元件，尽管存在动态力，但提供抵抗移动或定向障碍。