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    31.
    发明专利
    未知

    公开(公告)号：FI925370A0

    公开(公告)日：1992-11-26

    申请号：FI925370

    申请日：1992-11-26

    Applicant: HOECHST AG

    Inventor： FRICK WENDELIN ,  MUELLER GUENTER ,  MUELLNER STEFAN ,  BREIPOHL GERARD

    IPC: A61K38/28 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

    Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

    33.
    发明专利
    未知

    公开(公告)号：MX9200333A

    公开(公告)日：1992-08-01

    申请号：MX9200333

    申请日：1992-01-27

    Applicant: HOECHST AG

    Inventor： AIGNER RUDOLF ,  MUELLER GUENTER ,  SCHOLZ HANS JUERGEN ,  WEHLE DETLEF

    IPC: C07C213/02 ,  C07C213/04 ,  C07C215/10 ,  C07C213/08

    Abstract: The novel process is based on the reaction of a dialkylamine, preferably dimethylamine or diethylamine, with a monohalopropanediol, preferably monochloropropanediol, in the presence of water. The reaction is carried out in the presence of 25 to 70% by weight of water and at a temperature of from 20 to 80 DEG C, the dialkylamine being employed in an amount of at least 2.5 mol per mol of monohalopropanediol. The novel process allows a high space-time-yield and also a high chemical yield of virtually pure dialkylaminopropanediol to be obtained.

    35.
    发明专利
    未知

    公开(公告)号：NO309146B1

    公开(公告)日：2000-12-18

    申请号：NO924585

    申请日：1992-11-27

    Applicant: HOECHST AG

    Inventor： FRICK WENDELIN ,  MUELLER GUENTER ,  MUELLNER STEFAN ,  BREIPOHL GERHARD

    IPC: A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

    Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

    INOZITOL-GLYKANES OF INZULIN-LIKE ACTIVITY
    36.
    发明专利
    INOZITOL-GLYKANES OF INZULIN-LIKE ACTIVITY 未知

    公开(公告)号：HU9702242A2

    公开(公告)日：1998-12-28

    申请号：HU9702242

    申请日：1997-11-26

    Applicant: HOECHST AG

    Inventor： FRICK WENDELIN ,  MUELLER GUENTER

    IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00 ,  C07H15/02

    Abstract: Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).

    INOZITOL-GLYKANES OF INZULIN-LIKE ACTIVITY
    39.
    发明专利
    INOZITOL-GLYKANES OF INZULIN-LIKE ACTIVITY 未知

    公开(公告)号：HU9702242D0

    公开(公告)日：1998-03-02

    申请号：HU9702242

    申请日：1997-11-26

    Applicant: HOECHST AG

    Inventor： FRICK WENDELIN ,  MUELLER GUENTER

    IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00

    Abstract: Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).

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