公开(公告)号：DE58905462D1

公开(公告)日：1993-10-07

申请号：DE58905462

申请日：1989-12-11

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: A61K31/16 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07C291/02 ,  C07D213/81 ,  C07D233/64 ,  C07D295/18 ,  C07D333/24 ,  C07D521/00 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the general formula I (I) in which A denotes a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B denotes the radical of an amino acid and D denotes a CH2 group or a radical -NR7-, where R7 can be hydrogen or a (C1-C4)alkyl radical; and in which R1 to R4 are defined as indicated in the description, to a process for the preparation thereof, to agents containing these, and to the use thereof.

公开(公告)号：BR9202325A

公开(公告)日：1993-01-19

申请号：BR9202325

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANS JOERG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D213/00 ,  C07D413/00 ,  C07D401/00 ,  C07D417/00

Abstract: Compounds of the formula (I) in which X and Y are, for example, N, R , R and R are, for example, hydrogen, A and L are, for example, CH2 or CO, Z is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydroxyl, R is, for example, n is, for example, zero or 1, are active renin-inhibiting compounds which have a high in-vitro and in-vivo activity.

公开(公告)号：CZ190692A3

公开(公告)日：1993-01-13

申请号：CS190692

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds of the formula (I) in which X and Y are, for example, N, R , R and R are, for example, hydrogen, A and L are, for example, CH2 or CO, Z is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydroxyl, R is, for example, n is, for example, zero or 1, are active renin-inhibiting compounds which have a high in-vitro and in-vivo activity.

公开(公告)号：CS9001980A2

公开(公告)日：1991-08-13

申请号：CS198090

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/08

CPC classification number: C07K5/06078 ,  A61K38/00 ,  C07K5/0227

公开(公告)号：CS9001979A2

公开(公告)日：1991-08-13

申请号：CS197990

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  LINZ WOLFGANG DR ,  RUPPERT DIETER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K7/00

CPC classification number: C07K5/06078 ,  A61K38/00

公开(公告)号：DE3924506A1

公开(公告)日：1991-01-31

申请号：DE3924506

申请日：1989-07-25

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJOERG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER DR

IPC: C07C237/08 ,  C07C237/22 ,  C07D233/54 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07K5/065 ,  C07K5/078

Abstract: Peptide polyhydroxyalkylamides of formula (I) and their salts are new; where A = R1R6N-CHR5-CO-, R1R7CH-CHR5-CO- or R1O-CHR5-CO-; R1 = R'1 or R'1W; R'1 = (a) 3-8C cycloalkyl, CONH2, OCH2COOH, NH2, etc. (b) H, OH or 1-4C alkoxy, (c) 1-18C alkyl, quanidino, phenyl(1-4C)alkoxy, etc. (d) 6-14C aryl, (6-14C)aryl(1-4C)alkyl, etc. (e) Het or Het(1-4C)alkyl, where Het is an opt. benzo-fused 5- to 7-membered heterocyclic ring contg. 1 or 2 of N, O, S, No, etc. (f) NR8R9; Het or Het(1-4C)alkyl, or NR8R9 is a mono- or bicyclic 5- to 12-membered ring system opt. contg. 1 or 2 more N atoms, an S atom or an O atom, opt. substd. by 1-4C alkyl; W = CO, CS, OSO, SO2, SO, NHSO2, NHCO, CHOH or NOH; n = 2-10.

公开(公告)号：DE3842067A1

公开(公告)日：1990-06-21

申请号：DE3842067

申请日：1988-12-14

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: A61K31/16 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07C291/02 ,  C07D213/81 ,  C07D233/64 ,  C07D295/18 ,  C07D333/24 ,  C07D521/00 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The present invention relates to compounds of the general formula I (I) in which A denotes a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B denotes the radical of an amino acid and D denotes a CH2 group or a radical -NR7-, where R7 can be hydrogen or a (C1-C4)alkyl radical; and in which R1 to R4 are defined as indicated in the description, to a process for the preparation thereof, to agents containing these, and to the use thereof.

公开(公告)号：DE3841732A1

公开(公告)日：1990-06-13

申请号：DE3841732

申请日：1988-12-10

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD PROF DR

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P9/12 ,  A61P31/12 ,  C07D277/42 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: Compounds of the formula I in which R is (subst.) heterocyclyl-alkyl, -alkoxy, -cycloalkyl, -cycloalkoxy and the corresponding heterocyclylmercapto compounds, A and B are, independently of one another, an amino acid, R is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, aryl or aryl-alkyl, R is hydrogen, alkyl, aryl, aryl-alkyl or hydroxyl, and R is a radical (CH2)0-4CHR -D, with R = hydrogen, alkyl, alkoxy, alkylthio, alkylamino, hydroxyl, azido or halogen and D = (subst.) heterocyclyl, have enzyme-inhibiting properties. Processes for preparing compounds of the formula I and the use thereof for treating high blood pressure and viral diseases are described.

公开(公告)号：DE3627877A1

公开(公告)日：1988-02-04

申请号：DE3627877

申请日：1986-08-16

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: A61K31/415 ,  A61K38/00 ,  C07D233/54 ,  C07D233/64 ,  C07K1/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  A61K37/02 ,  A61K37/64

Abstract: The invention relates to compounds of the formula in which R1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R2, R3 and R4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.

公开(公告)号：DE4422911A1

公开(公告)日：1996-01-04

申请号：DE4422911

申请日：1994-06-30

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN DR ,  STAHL WILHELM DR ,  BUDT KARL-HEINZ DR ,  RUPPERT DIETER DR ,  SCHUESLER HENNING ,  WAGNER KONRAD

IPC: A61K31/675 ,  A61P31/12 ,  C07F9/6584

Abstract: Cyclic phosphinic acid derivs. of formula (I) are new: A = gp. of formulae (a) or (b); n = 0 or 1; Y, R = O or S; R = H, alkyl, alkenyl, etc.; R , R * = H, NH2, alkyl, etc.; or R +R * = 3-6 membered ring opt. contg. 1-3 heteroatoms, e.g. O or N; G, F = H, F, Cl, Br, OH or R ; but F = H when G = OH; R = H, 1-20C acyl, or OH pro-drug gp.; B = e.g. -C(L)-; L = e.g. O; D, D* = H, 1-20C Alk , R or R -(1-6C Alk ); Alk = satd., mono- or multiply-unsatd. or cyclic alkyl, etc.; R = satd., unsatd. or partly unsatd. 3-35C isocyclic or heterocyclic ring system contg. 3-9 membered rings, etc.; E, E* = H, satd. or unsatd. 1-7C alkyl opt. mono-, di- or tri-substd. by F, Cl, Br or 1-3C alkoxy, etc..