公开(公告)号：CA2152973C

公开(公告)日：2006-07-18

申请号：CA2152973

申请日：1995-06-29

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  STAHL WILHELM ,  BUDT KARL-HEINZ ,  RUPPERT DIETER ,  SCHUSSLER HENNING ,  WAGNER KONRAD

IPC: A61K31/675 ,  C07F9/6584 ,  A61P31/12

Abstract: Compounds of the formula I, (see formula I) in which the symbols or substituents A, B, D, D*, E and E* have the specified meanings, inhibit aspartyl proteases and are suitable for controlling viral diseases.

公开(公告)号：DE4422911A1

公开(公告)日：1996-01-04

申请号：DE4422911

申请日：1994-06-30

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN DR ,  STAHL WILHELM DR ,  BUDT KARL-HEINZ DR ,  RUPPERT DIETER DR ,  SCHUESLER HENNING ,  WAGNER KONRAD

IPC: A61K31/675 ,  A61P31/12 ,  C07F9/6584

Abstract: Cyclic phosphinic acid derivs. of formula (I) are new: A = gp. of formulae (a) or (b); n = 0 or 1; Y, R = O or S; R = H, alkyl, alkenyl, etc.; R , R * = H, NH2, alkyl, etc.; or R +R * = 3-6 membered ring opt. contg. 1-3 heteroatoms, e.g. O or N; G, F = H, F, Cl, Br, OH or R ; but F = H when G = OH; R = H, 1-20C acyl, or OH pro-drug gp.; B = e.g. -C(L)-; L = e.g. O; D, D* = H, 1-20C Alk , R or R -(1-6C Alk ); Alk = satd., mono- or multiply-unsatd. or cyclic alkyl, etc.; R = satd., unsatd. or partly unsatd. 3-35C isocyclic or heterocyclic ring system contg. 3-9 membered rings, etc.; E, E* = H, satd. or unsatd. 1-7C alkyl opt. mono-, di- or tri-substd. by F, Cl, Br or 1-3C alkoxy, etc..

公开(公告)号：AU708253B2

公开(公告)日：1999-07-29

申请号：AU2332495

申请日：1995-06-28

Applicant: HOECHST AG

Inventor： PEYMANN ANUSCHIRWAN ,  STAHL WILHELM ,  BUDT KARL-HEINZ ,  RUPPERT DIETER ,  SCHUSSLER HENNING ,  WAGNER KONRAD

IPC: A61K31/675 ,  A61P31/12 ,  C07F9/6584 ,  A61K31/66

Abstract: Cyclic phosphinic acid derivs. of formula (I) are new: A = gp. of formulae (a) or (b); n = 0 or 1; Y, R = O or S; R = H, alkyl, alkenyl, etc.; R , R * = H, NH2, alkyl, etc.; or R +R * = 3-6 membered ring opt. contg. 1-3 heteroatoms, e.g. O or N; G, F = H, F, Cl, Br, OH or R ; but F = H when G = OH; R = H, 1-20C acyl, or OH pro-drug gp.; B = e.g. -C(L)-; L = e.g. O; D, D* = H, 1-20C Alk , R or R -(1-6C Alk ); Alk = satd., mono- or multiply-unsatd. or cyclic alkyl, etc.; R = satd., unsatd. or partly unsatd. 3-35C isocyclic or heterocyclic ring system contg. 3-9 membered rings, etc.; E, E* = H, satd. or unsatd. 1-7C alkyl opt. mono-, di- or tri-substd. by F, Cl, Br or 1-3C alkoxy, etc..

公开(公告)号：CA2152973A1

公开(公告)日：1995-12-31

申请号：CA2152973

申请日：1995-06-29

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  STAHL WILHELM ,  BUDT KARL-HEINZ ,  RUPPERT DIETER ,  SCHUEBETALER HENNING ,  WAGNER KONRAD

IPC: A61K31/675 ,  A61P31/12 ,  C07F9/6584

Abstract: Compounds of the formula I, (I) in which the symbols or substituents A, B, D, D*, E and E* have the specified meanings, inhibit aspartyl proteases and are suitable for controlling viral diseases.