公开(公告)号：DK270789A

公开(公告)日：1989-12-05

申请号：DK270789

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645 ,  C07K7/10

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：NO892266D0

公开(公告)日：1989-06-02

申请号：NO892266

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：DK270789D0

公开(公告)日：1989-06-02

申请号：DK270789

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645 ,  C07K7/10

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：FI892686A0

公开(公告)日：1989-06-01

申请号：FI892686

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645 ,  C07K

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：DK630688A

公开(公告)日：1989-05-14

申请号：DK630688

申请日：1988-11-11

Applicant: HOECHST AG

Inventor： BADZIONG WERNER ,  CRAUSE PETER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE

IPC: G01N30/88 ,  A61K35/62 ,  B01D15/08 ,  C07K1/14 ,  C07K1/20 ,  C07K14/00 ,  C07K14/435 ,  C07K14/815 ,  G01N30/26 ,  C07K3/20

Abstract: Hirudin is isolated and purified from complex and salt-containing solutions by hydrophobic chromatography employing porous adsorber resins as stationary phase and water-miscible organic solvents as mobile phase.

公开(公告)号：AU566133B2

公开(公告)日：1987-10-08

申请号：AU1795783

申请日：1983-08-12

Applicant: HOECHST AG

Inventor： SEIPKE GERHARD ,  TRIPIER DOMINIQUE ,  JOHNSCHER GERD

IPC: A61K35/26 ,  A61K38/00 ,  A61K38/22 ,  A61P37/00 ,  C07K1/113 ,  C07K1/20 ,  C07K7/04 ,  C07K14/435 ,  C07K14/47 ,  C07K14/575 ,  C07C103/52 ,  C12P21/00

Abstract: The invention relates to a polypeptide which can be isolated from thymus glands and has an action on the immunological system, and which has a molecular weight of 3,480, a UV absorption with a maximum at 205 to 210 nm and an isoelectric point of 3.95+0.15 and a specific aminoacid composition, the N-terminal, if appropriate, carrying an acyl group or an acylglycyl group, processes for its isolation and purification, its use, agents containing this polypeptide, and its cleavage products, their use and agents containing them.

公开(公告)号：HU192495B

公开(公告)日：1987-06-29

申请号：HU412184

申请日：1984-11-06

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  TRIPIER DOMINIQUE ,  RITZEL HARALD

IPC: C12N1/20 ,  A61K35/74 ,  A61K38/00 ,  A61K38/55 ,  C07K7/00 ,  C07K7/64 ,  C07K14/00 ,  C07K14/195 ,  C07K14/36 ,  C07K14/41 ,  C12N9/99 ,  C12P7/64 ,  C12P13/00 ,  C12P21/02 ,  C12P21/04 ,  C12R1/485

Abstract: Cyclic polypeptides of the formula I I in which Z, S, Y and AS have the meanings given, a process for their preparation and their use are described. The compounds have an alpha -amylase-inhibiting action.

公开(公告)号：NO862876L

公开(公告)日：1987-01-19

申请号：NO862876

申请日：1986-07-16

Applicant: HOECHST AG

Inventor： KRAMER MARTIN ,  TRIPIER DOMINIQUE

IPC: A61K35/62 ,  C07K1/06 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/00 ,  C07K1/12 ,  C07K1/14 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C07K

Abstract: The invention relates to a polypeptide of the formula (I) +TR in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.

公开(公告)号：ZA8502854B

公开(公告)日：1985-11-27

申请号：ZA8502854

申请日：1985-04-17

Applicant: HOECHST AG

Inventor： TRIPIER DOMINIQUE

IPC: C07K1/113 ,  A61K35/56 ,  A61K35/62 ,  A61K38/00 ,  A61K38/46 ,  A61K38/55 ,  A61P7/02 ,  C07C20060101 ,  C07G20060101 ,  C07K1/20 ,  C07K14/00 ,  C07K14/815 ,  C07C ,  C07G

CPC classification number: C07K14/815 ,  A61K38/00 ,  Y10S930/26

公开(公告)号：AU3519084A

公开(公告)日：1985-07-25

申请号：AU3519084

申请日：1984-11-07

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  TRIPIER DOMINIQUE ,  RITZEL HARALD

IPC: C12N1/20 ,  A61K35/74 ,  A61K38/00 ,  A61K38/55 ,  C07K7/00 ,  C07K7/64 ,  C07K14/00 ,  C07K14/195 ,  C07K14/36 ,  C07K14/41 ,  C12N9/99 ,  C12P7/64 ,  C12P13/00 ,  C12P21/02 ,  C12P21/04 ,  C12R1/485 ,  A61K37/02

Abstract: Cyclic polypeptides of the formula I I in which Z, S, Y and AS have the meanings given, a process for their preparation and their use are described. The compounds have an alpha -amylase-inhibiting action.