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    35.
    发明专利
    未知

    公开(公告)号：DK453686D0

    公开(公告)日：1986-09-23

    申请号：DK453686

    申请日：1986-09-23

    Applicant: HOECHST AG

    Inventor： WINKELMANN ERHARDT ,  ROLLY HEINRICH ,  WINKLER IRVIN

    IPC: A61K31/52 ,  C07D473/00 ,  C07D

    Abstract: Compounds of the formula 1 in which R is H, halogen, OH, SH, azido, NH2 or Z-R , where Z denotes O, S, SO, SO2 or NH and R denotes an acyclic aliphatic hydrocarbon radical having 1 to 6 C atoms, which a) is unsubstituted or b) is modified by at least one of the features that it contains an alkoxy group having 1 to 3 C atoms or a double bond or is at least partially fluorinated, or denotes cycloalkyl having 3 to 6 C atoms or phenylalkyl which is bonded directly to Z or via an alkylene group of 1 to 3 C atoms, or phenyl, where the phenyl ring can in each case be substituted at most twice, preferably at most once, by a substituent from the group halogen, trifluoromethyl, alkoxy and alkylthio each having 1 to 3 C atoms, R is H or has the meaning of R or is an acyl group CO-R , where R is alkyl having 1 to 6 C atoms, benzyl or phenyl, R denotes halogen, azido, unsubstituted amino or the radical Y-R , where R has the same meaning as R and Y, like X, denotes O, S, SO or SO2 and X and Y can be identical or different, where those compounds are excepted in which, at the same time, R is OH or SH, R is H, R is Y-R , X is O or S, Y is O and R is alkyl having 1 to 4 C atoms or in which, at the same time, R is OH or NH2, R is benzyl, R is Y-R where Y = O and R = benzyl and X is O, are used for the treatment of diseases caused by viruses.

    IN-VITRO TRANSCRIPTION PROCESSES FOR SCREENING NATURAL PRODUCTS AND OTHER CHEMICAL SUBSTANCES
    40.
    发明专利
    IN-VITRO TRANSCRIPTION PROCESSES FOR SCREENING NATURAL PRODUCTS AND OTHER CHEMICAL SUBSTANCES 未知

    公开(公告)号：CA2231745A1

    公开(公告)日：1998-09-12

    申请号：CA2231745

    申请日：1998-03-11

    Applicant: HOECHST AG

    Inventor： WINKLER IRVIN ,  MEISTERERNST MICHAEL ,  STAHL WILHELM ,  KIRSCHBAUM BERND

    IPC: C12N15/09 ,  C12N15/63 ,  C12P19/34 ,  C12Q1/68 ,  C12N15/11

    Abstract: The invention relates to an in-vitro process for analyzing transcription of vira l and cellular genes which can be automated and which is suitable for efficient and economical bulk screening with the aim of finding specific chemical lead structu res which have a selective effect on gene activity. The process for the cell-free in-vitro transcription of a DNA template comprisin g a DNA sequence to be transcribed which is under the control of at least one gene-regulatory element comprises a) using, for the transcription, a concentrated and, if appropriate, purified ex tract from cell nuclei which, if appropriate, can be complemented, or partially or ful ly replaced, by transcription factors and/or cofactors, and at least one labeled nucleotide, b) if appropriate isolating and/or degrading the proteins in the reaction mixtur e after transcription, c) binding the labeled transcript to a solid matrix, d) removing the excess labeled nucleotides and e) determining the amount of labeled transcript.

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