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    NEW ANTIBIOTIC SUBSTANCE FEGLYMYCIN, ITS PRODUCTION AND USE
    1.
    发明专利
    NEW ANTIBIOTIC SUBSTANCE FEGLYMYCIN, ITS PRODUCTION AND USE 失效

    公开(公告)号：JPH10204099A

    公开(公告)日：1998-08-04

    申请号：JP34263197

    申请日：1997-12-12

    Applicant: HOECHST AG

    Inventor： VERTESY LASZLO ,  KNAUF MARTIN ,  WINK JOACHIM ,  ISERT DIETER ,  STAHL WILHELM ,  RIESS GUNTHER ,  ASZODI JOZSEF ,  BELLER DOMINIQUE LE

    IPC: C12P1/06 ,  A61K38/00 ,  A61K38/10 ,  A61P31/00 ,  C07K7/08 ,  C12N1/20 ,  C12P21/02 ,  C12R1/465 ,  C12R1/645

    Abstract: PROBLEM TO BE SOLVED: To provide the subject new non-toxic substance produced by a specific microorganism of the genus Streptomyces, active as an antibiotic substance, having high tolerance and effectively inhibiting human immunodeficiency virus. SOLUTION: This substance is a compound of the formula, its salt or its chemically equivalent substance. It has the following properties. Appearance, colorless; solubility, soluble in methanol, acetonitrile and water; stability, stable under neutral or moderately alkaline conditions and unstable in strongly acidic or strongly alkaline solution; molecular formula, C95 H97 N13 O30 ; molecular weight, 1900.90; etc. The compound can be produced by the fermentation with a microorganism HAG 4674 (DSM 11171) of the genus Streptomyces, its variant or mutant. The fermentation is preferably carried out in a nutrient solution containing 1-2% of oat flake and a minor element solution of 0.2-0.3% concentration under aerobic condition at 25-30 deg.C and pH5.5-8.5 for 24-140hr.

    NEW POLYENE ANTIBIOTIC SUBSTANCE 3874H1 TO H6, THEIR PRODUCTION AND USE THEREOF
    2.
    发明专利
    NEW POLYENE ANTIBIOTIC SUBSTANCE 3874H1 TO H6, THEIR PRODUCTION AND USE THEREOF 失效

    公开(公告)号：JPH10120686A

    公开(公告)日：1998-05-12

    申请号：JP22225897

    申请日：1997-08-19

    Applicant: HOECHST AG

    Inventor： VERTESY LASZLO ,  KURZ MICHAEL ,  WINK JOACHIM ,  MARKUS ASTRID ,  STAHL WILHELM

    IPC: C12P17/18 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  A61P33/02 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P19/62 ,  C12R1/465

    Abstract: PROBLEM TO BE SOLVED: To obtain a novel polyene antibiotic substances 3874H1 to H6 which are produced by Streptomyces DSM11007 and is useful as an antifungal agent of a therapeutic agent for treatment of diseases relating to increased steroidal concentration. SOLUTION: This novel polyene antibiotic agent is produced by Streptomyces DSM11007 and comprises the following 6 substances: antibiotic substance 3874H1 is represented by formula I, has the molecular formula of C58 H86 N2 O18 and the molecular weight of 1099.3; the antibiotic substance 3874H2 is represented by formula II, has the molecular formula of C59 H88 N2 O18 and the molecular weight of 1113.3; the antibiotic substance 3874H3 is represented by formula III, has the molecular formula of C57 H87 N2 O18 and the molecular weight of 1074.3; the antibiotic substance 3874H4 is represented by formula IV, has the molecular formula of C58 H84 N2 O18 and the molecular weight of 1097.3; the antibiotic substance 3874H5 is represented by formula V, has the molecular formula of C57 H85 N2 O18 and the molecular weight of 1072.3. The agent is useful as an antifungal agent and for treatment of diseases relating to increased steroidalal concentration. These antibiotic substances are obtained by fermentation of Streptomyces DSM11007 or its mutant under appropriate conditions and isolating the products from the culture mixture, respectively.

    IN VITRO TRANSCRIPTION PROCESS FOR SCREENING OF NATURAL PRODUCTS AND OTHER CHEMICAL PRODUCTS
    6.
    发明专利
    IN VITRO TRANSCRIPTION PROCESS FOR SCREENING OF NATURAL PRODUCTS AND OTHER CHEMICAL PRODUCTS 未知

    公开(公告)号：HU9800526D0

    公开(公告)日：1998-05-28

    申请号：HU9800526

    申请日：1998-03-10

    Applicant: HOECHST AG

    Inventor： KIRSCHBAUM BERND ,  MEISTERERNST MICHAEL ,  STAHL WILHELM ,  WINKLER IRVIN

    IPC: C12N15/09 ,  C12N15/63 ,  C12P19/34 ,  C12Q1/68

    Abstract: Process for transcription of a DNA template in vitro in a cell-free system, where the template comprises a sequence to be transcribed under the control of at least one regulatory element, is characterised in that (a) an enriched and optionally purified extract of cell nuclei and at least one labelled nucleotide are used for the transcription, where the extract can optionally be supplemented or partly or completely replaced by transcription factors and/or cofactors, (b) proteins present in the reaction mixture at the end of transcription are optionally separated and/or degraded, (c) the labelled transcript is bound to a solid support, (d) excess labelled nucleotide is removed, and (e) the amount of labelled transcript is determined. Also claimed is a DNA template as above in which the sequence to be transcribed does not contain at least one nucleobase selected from G, C or T, where the G-, C- or T-free sequence has a length of more than 400 nucleotides.

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