公开(公告)号：JPH10158141A

公开(公告)日：1998-06-16

申请号：JP32150196

申请日：1996-12-02

Applicant: KAO CORP

Inventor： KITAHARA TAKASHI ,  NISHIMURA YOKO ,  NOJIRI HIROSHI ,  NITTA HIROYUKI ,  SATO NORIKO ,  HORI KIMIHIKO

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/96 ,  A61K8/98 ,  A61Q5/02 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a sebum secretion-inhibiting cosmetic which is useful in inhibition of sebum secretion on the skin and scalp by using a lipid higher in the polarity than cholesterol. SOLUTION: Skin surface lipid of mammalian animals is extracted with an organic solvent, for example, chloroform, preferably at 5-40 deg.C for 1-3 minutes, subjected to chromatography and eluted sequentially with a hexane/diethyl ether 1:1 volume ratio mixture, a hexane/diethyl ether 1:1 volume ratio mixture, and further with a higher polar solvent than the hexane/diethyl ether mixture (for example, an ether such as diethyl ether) to collect the fraction containing a lipid component higher than cholesterol in polarity (sebum lipid synthesis inhibitor). This inhibitor is formulated to a cosmetic in an amount of 0.01-50wt.% and is used as a sebum secretion-inhibiting cosmetic (cosmetic of external use for skin or for hair growth and restoration).

公开(公告)号：JPH1077221A

公开(公告)日：1998-03-24

申请号：JP23422196

申请日：1996-09-04

Applicant: KAO CORP

Inventor： IMAI TAKEO ,  YAGO YUKO ,  NITTA HIROYUKI ,  KITAHARA TAKASHI ,  HORI KIMIHIKO ,  HOTTA HAJIME

IPC: A61K8/63 ,  A61K8/00 ,  A61K8/96 ,  A61K8/97 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00 ,  A61K7/025 ,  A61K7/032

Abstract: PROBLEM TO BE SOLVED: To prepare oily solid cosmetic effective in prevention and improvement of roughened skin such as desquamation, peeling of the skin, etc., willingly developed on the skin, lip, etc., having low irritation and good in strength and feeling of use by blending a specific amount of an inhibitor against cell adhesion, a cholesterol derivative and an antiinflammatory agent. SOLUTION: The oily solid cosmetics is obtained by blending 0.001-5wt.% inhibitor against cell adhesion, 0.001-40wt.% cholesterol decorative and 0.001-5wt.% antiinflammatory agent. A plant extract selected from oily Glychyrrhizae Radix extract, Lithospermum erythrorhizon extract and Cephaelis ipecacuanha extract is suitable as the inhibitor against cell adhesion because of easy procurement. The oily Glycyrrhizae Radix extract is obtained by extracting Glycyrrhiza glabrea, Glycyrrhiza inflata Glycyrrhiza uralensis, etc., by an organic solvent. Cholesteryl oleate, cholesteryl nonanate, etc., are used as the chlesterol derivative. Glycyrrhizic acid, allanbtoin, etc., are used as the antiinmflammatory agent.

公开(公告)号：JPH08337537A

公开(公告)日：1996-12-24

申请号：JP14857795

申请日：1995-06-15

Applicant: KAO CORP

Inventor： NITTA HIROYUKI ,  KITAHARA TAKASHI ,  HORI KIMIHIKO ,  YOSHIDA EISAKU

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/64 ,  A61K38/00 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  C07K7/06 ,  C07K7/08 ,  A61K7/00

Abstract: PURPOSE: To obtain a new peptide having specific amino acid sequences, capable of inhibiting an intercellular adhesion by inhibiting the formation of desmosome which is a cell to cell adhesion device, useful for the prevention and therapy of dermal diseases, and the improvement of troubles in corneum. CONSTITUTION: This intercellular adhesion inhibiting peptide is a peptide or its salt, having amino acid sequences selected from formulas I to IV equivalent to the partial sequences of amino acid sequences of a desmocollin and formula V equivalent to the partial sequences of amino acid sequences of a desmoglein. The peptide is preferably obtained by using a known peptide synthetic method such as a solid phase method and a liquid phase method. The above peptide can be used as a dermal preparation for external use, and blending it by 0.01-30wt.% in the dermal preparation for external use is preferable. As a base used for preparing the dermal preparation for external use, e.g. a vaseline, a paraffin, a polyethylene glycol and water are cited. Also, an emulsifying agent, a suspending agent, a preserving agent, a stabilizing agent, etc., can be blended as necessary.

公开(公告)号：JPH05186328A

公开(公告)日：1993-07-27

申请号：JP373792

申请日：1992-01-13

Applicant: KAO CORP

Inventor： ISHIDA KOICHI ,  MORIOKA TOMONORI ,  KITAHARA TAKASHI ,  IKEDA NORIKO

IPC: A61K8/00 ,  A61K8/34 ,  A61K8/89 ,  A61K8/891 ,  A61K8/92 ,  A61K8/97 ,  A61K8/98 ,  A61Q19/00 ,  A61Q19/10 ,  C08G77/04 ,  C08L83/04 ,  C11D7/60

Abstract: PURPOSE:To obtain a nonaqueous skin washing and cleanly wiping agent compound having excellently sebum eliminating ability and high symptom improving effects on skin diseases by combining an oil such as vegetable oil with a lower alcohol and a volatile polysiloxane. CONSTITUTION:A nonaqueous skin washing and cleanly wiping agent compound comprising one or more oils selected from vegetable oils such as olive oil or almond oil, animal oils such as lanolin, turtle oil or squalane and synthetic oils such as liquid paraffin or isoparaffin, a volatile polysiloxane [especially preferably one selected from compounds of formula I m is 4-8) and formula II (n is 3-8)] and a lower alcohol. This composition can effectively moves sebum, one of causes of various skin diseases and is effective for improving and preventing symptoms of skin diseases such as acne vulgaris.

公开(公告)号：JPS63203625A

公开(公告)日：1988-08-23

申请号：JP3652187

申请日：1987-02-19

Applicant: KAO CORP

Inventor： KITAHARA TAKASHI ,  YOSHIDA EISAKU ,  AKATSU MITSUHIRO ,  JOKURA YOJI ,  HATTORI MICHIHIRO ,  TAKAISHI NAOTAKE

IPC: A61K8/00 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61K36/52 ,  A61P35/00 ,  A61P43/00 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q7/02 ,  A61Q15/00

Abstract: PURPOSE:To obtain a 5alpha-reductase inhibitor useful for treating and preventing male-hormone related epidemics such as male alopecia, hirsutism, prostatic hypertropy, etc., containing an extract from leaves and/or pericarp of walnut as an active ingredient. CONSTITUTION:Leaves and/or pericarp of walnut is preferably dried, powdered, immersed and extracted with a solvent (e.g. polyethylene glycol) at normal temperature or under pressure or extracted with Soxhlet's extractor to give an extract. The extract may be directly used as it is as a 5alpha-reductase or mixed with ordinary drug additives and pharmaceutically manufactured into tablet, powder, granule, capsule, solution, etc., by a conventional procedure to give the aimed substance. A dose is 1mg-1g per adult one time and administered one time - several times/day in the case of prostatic hypertropy and a dose is 10mug-100mg and administered one time - several times/day in the case of apopecia treatment.