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    BATHING AGENT
    4.
    发明专利
    BATHING AGENT 失效

    公开(公告)号：JPS63246319A

    公开(公告)日：1988-10-13

    申请号：JP8048087

    申请日：1987-04-01

    Applicant: KAO CORP

    Inventor： YOROZU HIDENORI ,  SATO HIROTAKA ,  AKATSU MITSUHIRO ,  YOSHIDA EISAKU

    IPC: A61K8/00 ,  A61K8/25 ,  A61K8/36 ,  A61K8/362 ,  A61K8/73 ,  A61K8/97 ,  A61Q19/10

    Abstract: PURPOSE:To obtain a bathing agent having excellent effect, stable over a long period, easily usable without clouding the bath water and free from vehicle, by compounding dried powder of extraction liquid of SENKYU (rhizome of Cnidium officinale) and/or TOKI (root of Angelica acutiloba) prepared by specific extraction and production process. CONSTITUTION:SENKYU and/or TOKI are extracted with hot water of 80-100 deg.C for 2-10hr and the obtained hot water extract is joined with a recovered component produced by recovering volatile component evaporated in the hot-water extraction process. The obtained extraction liquid of SENKYU and/or TOKI is dried and the obtained dry powder is used as an active component of the objective bathing agent. The agent is preferably used as a weakly acidic agent by combining with carbon dioxide gas or carbon dioxide gas-generating component. The carbon dioxide gas is dissolved in the extract under high pressure or the extract is combined with a carbon dioxide gas-holding substance or generating substance. In the case of using the dried powder of the extracted crude drug used as the active component in combination with carbon dioxide gas or carbon dioxide gas-generating substance, the amount of the dried powder of the extracted crude drug is preferably 1-30%, especially 5-20% based on the whole composition.

    ANTIINFLAMMATORY AGENT
    5.
    发明专利
    ANTIINFLAMMATORY AGENT 失效

    公开(公告)号：JPH06211684A

    公开(公告)日：1994-08-02

    申请号：JP2497093

    申请日：1993-01-21

    Applicant: KAO CORP

    Inventor： YOSHIZUKA NAONOBU ,  YOSHIDA EISAKU

    IPC: A61K38/00 ,  A61P29/00 ,  A61P37/08 ,  C07K7/06 ,  A61K37/02

    Abstract: PURPOSE:To obtain an antiinflammatory agent, comprising a peptide containing a specific amino acid sequence as an active ingredient, having high safety and excellent suppressing activity against macrophage chemotaxis and useful for treating allergic diseases, etc., to be classified into delayed type hypersensitivity such as contact dermatitis or eczema. CONSTITUTION:This antiinflammatory agent is obtained by using a chloromethyl resin, an oxymethyl resin and a benzhydrylamine resin as a solid-phase support and successively binding an alpha-amino-protected amino acid thereto according to a solid-phase synthetic method for a peptide, synthesizing a protected peptide chain, then removing the protecting groups, cleaving the peptide from the resin, purifying the obtained peptide by high-performance liquid chromatography, etc., and providing a peptide (salt) having at least one amino acid sequence expressed by formula I (W is Arg or Gly), formulas II and III (X is Glu, Gin or Gly) and formula IV and having

    NEW PEPTIDE
    6.
    发明专利
    NEW PEPTIDE 失效

    公开(公告)号：JPH09227592A

    公开(公告)日：1997-09-02

    申请号：JP6892597

    申请日：1997-03-07

    Applicant: KAO CORP

    Inventor： OSAWA TOSHIAKI ,  YOSHIZUKA NAONOBU ,  YOSHIMURA MASAAKI ,  YOSHIDA EISAKU

    IPC: C12P21/02 ,  A61K38/00 ,  A61P35/00 ,  A61P37/04 ,  C07K7/06 ,  C07K14/47 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C12R1/91

    Abstract: PROBLEM TO BE SOLVED: To obtain a new peptide of macrophage chemotaxis factor, having a specific amino acid sequence, originated from human peripheral blood lymphocyte, exhibiting a macrophage chemotaxis activity, and useful as a reagent for researching delayed-type hypersensitivity, an antitumor agent, etc. SOLUTION: This new peptide (salt) has an amino acid sequence of the formula (X is Glu, Gln), has a macrophage chemotaxis activity and is useful as a reagent for researching delayed-type hypersensitivity, as medicines such as an antitumor agent. The new peptide is obtained by fusing a human peripheral blood lymphocyte stimulated with phytohemagglutinin with human acute t-cell leukemic cell strain CEM-11 by an emetine-actinomycin method, incubating the obtained human T-cell hybridoma in a culture medium in the presence of 5% CO2 at 37 deg.C, centrifuging the culture solution, collecting the supernatant and subsequently purifying the supernatant by an ultrafiltration method, a column chromatography, etc.

    HAIR-SOFTENING COSMETIC
    7.
    发明专利
    HAIR-SOFTENING COSMETIC 失效

    公开(公告)号：JPH07316033A

    公开(公告)日：1995-12-05

    申请号：JP10823494

    申请日：1994-05-23

    Applicant: KAO CORP

    Inventor： KAWADA YUZO ,  TSUCHIYA MAYUMI ,  MURAKADO CHIE ,  YAMAZAKI SEIJI ,  OHASHI YUKIHIRO ,  NAGAI MINORU ,  YOSHIDA EISAKU

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/36 ,  A61K8/362 ,  A61K8/40 ,  A61K8/44 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To prepare the skin-softening cosmetic not tacky on employment and capable of imparting flexibility to skin. CONSTITUTION:The skin-softening cosmetic contains (A) 0.01-30wt.%, preferably 0.01-20wt.%, of a carboxylic acid having two or more carboxyl groups or its salt, preferably succinic acid or citric acid, (B) 0.0001-19wt.%, preferably 0.0045-19.8wt.%, of a betaine, preferably glycine betaine, and (C) a basic amino acid or its salt, preferably arginine, in an amount of 0.01-100 pts.wt., preferably 0.05-30 pts.wt., per pt.wt. of the component A, and is controlled at a pH of preferably 3-8, especially 4-7. The cosmetic may, if necessary, further be compounded with one or more arbitrary components usually used for cosmetics, quasidrugs, medicines, etc.

    INTERCELLULAR ADHESION INHIBITING PEPTIDE
    8.
    发明专利
    INTERCELLULAR ADHESION INHIBITING PEPTIDE 失效

    公开(公告)号：JPH08337537A

    公开(公告)日：1996-12-24

    申请号：JP14857795

    申请日：1995-06-15

    Applicant: KAO CORP

    Inventor： NITTA HIROYUKI ,  KITAHARA TAKASHI ,  HORI KIMIHIKO ,  YOSHIDA EISAKU

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/64 ,  A61K38/00 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  C07K7/06 ,  C07K7/08 ,  A61K7/00

    Abstract: PURPOSE: To obtain a new peptide having specific amino acid sequences, capable of inhibiting an intercellular adhesion by inhibiting the formation of desmosome which is a cell to cell adhesion device, useful for the prevention and therapy of dermal diseases, and the improvement of troubles in corneum. CONSTITUTION: This intercellular adhesion inhibiting peptide is a peptide or its salt, having amino acid sequences selected from formulas I to IV equivalent to the partial sequences of amino acid sequences of a desmocollin and formula V equivalent to the partial sequences of amino acid sequences of a desmoglein. The peptide is preferably obtained by using a known peptide synthetic method such as a solid phase method and a liquid phase method. The above peptide can be used as a dermal preparation for external use, and blending it by 0.01-30wt.% in the dermal preparation for external use is preferable. As a base used for preparing the dermal preparation for external use, e.g. a vaseline, a paraffin, a polyethylene glycol and water are cited. Also, an emulsifying agent, a suspending agent, a preserving agent, a stabilizing agent, etc., can be blended as necessary.

    NOVEL PEPTIDE
    10.
    发明专利
    NOVEL PEPTIDE 失效

    公开(公告)号：JPH03215496A

    公开(公告)日：1991-09-20

    申请号：JP838090

    申请日：1990-01-19

    Applicant: KAO CORP

    Inventor： OSAWA TOSHIAKI ,  YOSHIDA EISAKU ,  YOSHIZUKA NAONOBU ,  KONDO MIYOKO

    IPC: A61K38/00 ,  A61P35/00 ,  C07K7/06

    Abstract: NEW MATERIAL:A peptide expressed by the formula or a salt of said peptide ((m) is H or acetyl; A is unsubstituted or L-Trp, etc.; B is L-Arg, etc.; C is Gly, etc.; D is L-Gln, etc.; E is L-Ser, etc.; F is Gly or L-Asp, etc.; G is unsubstituted or Gly; H is unsubstituted or L-Ser; I is unsubstituted or L-Glu; (n) is hydroxyl group or amide group). USE:Used as a reagent for an investigation of delayed hypersensitivity or as an antitumor drug. PREPARATION:For instance, a 4-(oxymethyl)phenylacetamide methyl resin, etc., is used as a solid phase carrier and alpha-amino-protected amino acid is bonded to the carrier from C-terminal of a peptide, in turn, to remove alpha-amino protecting group by a solid synthesizing method. Then, said process is repeated to synthesize a peptidyl resin, and the peptide is isolated from the resin and the protecting group is removed to afford the objective peptide expressed by the formula.

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