公开(公告)号：SG10201505619QA

公开(公告)日：2015-08-28

申请号：SG10201505619Q

申请日：2012-09-07

Applicant: PHARMACYCLICS INC

Inventor： KLOOS IOANA ,  ROBERT RENATA ,  JACQUET-BESCOND ANNE ,  DEPIL STÉPHANE ,  CHENEL MARYLORE ,  FOULIARD SYLVAIN ,  BALASUBRAMANIAN SRIRAM

Abstract: N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterised in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.

公开(公告)号：ZA201401710B

公开(公告)日：2015-01-28

申请号：ZA201401710

申请日：2014-03-07

Applicant: LES LABORATORIES SERVIER ,  PHARMACYCLICS INC

Inventor： KLOOS IOANA ,  JACQUET-BESCOND ANNE ,  CHENEL MARYLORE ,  BALASUBRAMANIAN SRIRAM ,  ROBERT RENATA ,  DEPIL STEPHANE ,  FOULIARD SYLVAIN

IPC: A61K20060101 ,  A61P20060101

Abstract: N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterised in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.

公开(公告)号：AU2011376953A1

公开(公告)日：2014-03-06

申请号：AU2011376953

申请日：2011-09-13

Applicant: PHARMACYCLICS INC ,  SERVIER SAS LAB

Inventor： LOURY DAVID J ,  BUGGY JOSEPH J ,  MODY TARAK D ,  VERNER ERIK J ,  PURRO NORBERT ,  BALASUBRAMANIAN SRIRAM ,  KLOOS IOANA ,  DEPIL STEPHANE

IPC: A61K31/343 ,  A61K31/16 ,  A61K31/166 ,  A61P35/00

Abstract: Dosing regimens, methods of treatment, controlled release formulations, and combination therapies that include bendamustine, or a pharmaceutically acceptable salt thereof and an HDAC inhibitor, or a pharmaceutically acceptable salt thereof, are described.

公开(公告)号：CA2864736A1

公开(公告)日：2013-08-22

申请号：CA2864736

申请日：2013-02-15

Applicant: PHARMACYCLICS INC

Inventor： BALASUBRAMANIAN SRIRAM ,  MODY TARAK D

IPC: A61K31/506 ,  A61K31/517 ,  A61P35/00

公开(公告)号：CA2721218A1

公开(公告)日：2009-10-22

申请号：CA2721218

申请日：2009-04-15

Applicant: PHARMACYCLICS INC

Inventor： VERNER ERIK ,  BALASUBRAMANIAN SRIRAM ,  BUGGY JOSEPH J

IPC: C07D235/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.

公开(公告)号：HK1200095A1

公开(公告)日：2015-07-31

申请号：HK15100523

申请日：2015-01-16

Applicant: PHARMACYCLICS INC

Inventor： LOURY DAVID J ,  BUGGY JOSEPH J ,  MODY TARAK D ,  VERNER ERIK J ,  PURRO NORBERT ,  BALASUBRAMANIAN SRIRAM ,  KLOOS IOANA ,  DEPIL STPHANE

IPC: A61K20060101 ,  A61P20060101

公开(公告)号：SG11201404888SA

公开(公告)日：2014-09-26

申请号：SG11201404888S

申请日：2013-02-15

Applicant: PHARMACYCLICS INC

Inventor： BALASUBRAMANIAN SRIRAM ,  MODY TARAK D

IPC: A61K31/506 ,  A61K31/517 ,  A61P35/00

公开(公告)号：SG2014014419A

公开(公告)日：2014-07-30

申请号：SG2014014419

申请日：2011-09-13

Applicant: PHARMACYCLICS INC ,  SERVIER SAS LAB

Inventor： LOURY DAVID J ,  BUGGY JOSEPH J ,  MODY TARAK D ,  VERNER ERIK J ,  PURRO NORBERT ,  BALASUBRAMANIAN SRIRAM ,  KLOOS IOANA ,  DEPIL STÉPHANE

IPC: A61K31/343 ,  A61K31/16 ,  A61K31/166 ,  A61P35/00

公开(公告)号：AU2012306122A1

公开(公告)日：2014-03-13

申请号：AU2012306122

申请日：2012-09-07

Applicant: SERVIER LAB ,  PHARMACYCLICS INC

Inventor： KLOOS IOANA ,  ROBERT RENATA ,  JACQUET-BESCOND ANNE ,  DEPIL STEPHANE ,  CHENEL MARYLORE ,  FOULIARD SYLVAIN ,  BALASUBRAMANIAN SRIRAM

IPC: A61K31/138 ,  A61K31/343 ,  A61K31/704 ,  A61K33/24 ,  A61P35/00

Abstract: A novel scheme for administering N-hydroxy-4-{2-[3-{N,N-dimethylaminomethyl)benzofuran-2-ylcarbonyl­amino]ethoxy}benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in combination with a surgical, chemotherapy or hormone therapy treatment or with radiotherapy, for the treatment of cancer, characterized in that it is administered for 4 consecutive days, this period being followed by 3 consecutive days without any administration of the compound of formula (I), wherein it is understood that the chemotherapy treatment is not FOLFOX.

公开(公告)号：CA2862259A1

公开(公告)日：2013-07-04

申请号：CA2862259

申请日：2012-12-19

Applicant: PHARMACYCLICS INC

Inventor： VERNER ERIK ,  CHEN WEI ,  BALASUBRAMANIAN SRIRAM

IPC: C07C259/06 ,  A61K31/165 ,  A61K31/18 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/455 ,  A61P35/00 ,  A61P35/02 ,  C07D211/40 ,  C07D213/30 ,  C07D213/38 ,  C07D213/63 ,  C07D213/81 ,  C07D295/088 ,  C07D401/06 ,  C07D405/06

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.