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1.发明申请
公开(公告)号：WO2007109178A9
公开(公告)日：2008-10-16
申请号：PCT/US2007006714
申请日：2007-03-16
Applicant: PHARMACYCLICS INC , BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
Inventor： BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
IPC: A61K31/405 , C07D209/00 , C07D209/04 , C07D209/12 , C07D209/18
CPC classification number: C07D209/08 , A61K31/404 , A61K31/5377 , A61K45/06 , C07D209/12 , C07D209/14 , C07D209/42 , C07D403/06 , A61K2300/00 , A61K31/55
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
Abstract translation: 本文描述的是含有这种化合物的化合物和药物组合物，其抑制组蛋白脱乙酰酶8（HDAC8）的活性。 本文还描述了将这样的HDAC8抑制剂单独使用并与其它化合物联合用于治疗将受益于抑制HDAC8活性的疾病或病症的方法。
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2.发明申请
公开(公告)号：WO2007109178A2
公开(公告)日：2007-09-27
申请号：PCT/US2007006714
申请日：2007-03-16
Applicant: PHARMACYCLICS INC , BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
Inventor： BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
IPC: A61K31/55 , A61K31/405
CPC classification number: C07D209/08 , A61K31/404 , A61K31/5377 , A61K45/06 , C07D209/12 , C07D209/14 , C07D209/42 , C07D403/06 , A61K2300/00 , A61K31/55
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
Abstract translation: 本文描述的是含有这种化合物的化合物和药物组合物，其抑制组蛋白脱乙酰酶8（HDAC8）的活性。 本文还描述了将这样的HDAC8抑制剂单独使用并与其它化合物联合用于治疗将受益于抑制HDAC8活性的疾病或病症的方法。
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公开(公告)号：WO2009129335A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040709
申请日：2009-04-15
Applicant: PHARMACYCLICS INC , VERNER ERIK , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH J
Inventor： VERNER ERIK , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH J
IPC: C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14
CPC classification number: A61K45/06 , A61K31/40 , A61K31/404 , A61K31/4439 , A61K31/5377 , C07D207/337 , C07D209/08 , C07D209/12 , C07D209/14 , C07D235/06 , C07D307/79 , C07D307/80 , C07D333/54 , C07D333/56 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D471/04
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
Abstract translation: 本文描述的是含有这种化合物的化合物和药物组合物，其抑制组蛋白脱乙酰酶8（HDAC8）的活性。 本文还描述了将这样的HDAC8抑制剂单独使用并与其它化合物联合用于治疗将受益于抑制HDAC8活性的疾病或病症的方法。
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公开(公告)号：EP2265590A4
公开(公告)日：2012-04-25
申请号：EP09733489
申请日：2009-04-15
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH J
IPC: C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14
CPC classification number: A61K45/06 , A61K31/40 , A61K31/404 , A61K31/4439 , A61K31/5377 , C07D207/337 , C07D209/08 , C07D209/12 , C07D209/14 , C07D235/06 , C07D307/79 , C07D307/80 , C07D333/54 , C07D333/56 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D471/04
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
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5.发明公开CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 审中-公开ZIMTSÄUREHYDROXYAMIDEAS蛋白去乙酰化酶8的抑制剂
公开(公告)号：EP2797875A4
公开(公告)日：2015-09-02
申请号：EP12863933
申请日：2012-12-19
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , CHEN WEI , BALASUBRAMANIAN SRIRAM
IPC: C07C259/06 , A61K31/165 , A61P43/00 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06 , C07D405/06
CPC classification number: C07D405/06 , C07C235/34 , C07C235/38 , C07C259/06 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06
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Patent Agency Ranking6.发明公开FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR IN COMBINATION WITH BENDAMUSTINE AND USES THEREOF 有权结合本达·马斯廷和组蛋白去乙酰化酶抑制剂配方及其用途
公开(公告)号：EP2755648A4
公开(公告)日：2015-03-11
申请号：EP11872389
申请日：2011-09-13
Applicant: PHARMACYCLICS INC , SERVIER SAS LAB
Inventor： LOURY DAVID J , BUGGY JOSEPH J , MODY TARAK D , VERNER ERIK J , PURRO NORBERT , BALASUBRAMANIAN SRIRAM , KLOOS IOANA , DEPIL STÉPHANE
IPC: A61K31/343 , A61K31/16 , A61K31/166 , A61P35/00
CPC classification number: A61K31/343 , A61K9/14 , A61K9/28 , A61K9/70 , A61K31/4184 , A61K2300/00
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7.发明公开METHODS FOR DETERMINING CANCER RESISTANCE TO HISTONE DEACETYLASE INHIBITORS 审中-公开程序用于确定癌症的抗组蛋白DEACETYLASEHEMMER
公开(公告)号：EP2107911A4
公开(公告)日：2010-09-22
申请号：EP08728620
申请日：2008-01-30
Applicant: PHARMACYCLICS INC
Inventor： BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM
IPC: G01N33/574 , C12Q1/68
CPC classification number: C12Q1/6886 , C07H21/04 , C12N5/0693 , C12N15/11 , C12N2503/02 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/57419 , G01N33/57492 , G01N2800/52
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公开(公告)号：NZ622112A
公开(公告)日：2016-07-29
申请号：NZ62211212
申请日：2012-09-07
Applicant: PHARMACYCLICS INC
Inventor： KLOOS IOANA , ROBERT RENATA , JACQUET-BESCOND ANNE , DEPIL STÉPHANE , CHENEL MARYLORE , FOULIARD SYLVAIN , BALASUBRAMANIAN SRIRAM
IPC: A61K31/138 , A61K31/343 , A61K31/704 , A61K33/24 , A61P35/00
Abstract: Disclosed herein is the use of the compound of formula I N-hydroxy-4-{ 2-[3-{ N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy} benzamide (abexinostat/PCI-24781): or an addition salt thereof with a pharmaceutically acceptable acid or base in the manufacture of a medicament for use in the treatment of cancer wherein the medicament is to be administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), in a human patient in need thereof. Also disclosed is the use in combination with a surgical, chemotherapy or hormone therapy treatment or with radiotherapy, wherein the chemotherapy treatment is not FOLFOX.
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公开(公告)号：SG11201400120UA
公开(公告)日：2014-09-26
申请号：SG11201400120U
申请日：2012-09-07
Applicant: SERVIER LAB , PHARMACYCLICS INC
Inventor： KLOOS IOANA , ROBERT RENATA , JACQUET-BESCOND ANNE , DEPIL STÉPHANE , CHENEL MARYLORE , FOULIARD SYLVAIN , BALASUBRAMANIAN SRIRAM
IPC: A61K31/138 , A61K31/343 , A61K31/704 , A61K33/24 , A61P35/00
Abstract: N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterised in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.
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公开(公告)号：FR2977492B1
公开(公告)日：2013-07-05
申请号：FR1102087
申请日：2011-07-04
Applicant: SERVIER LAB , PHARMACYCLICS INC
Inventor： DEPIL STEPHANE , JACQUET BESCOND ANNE , KLOOS IOANA , SARRY ANNE LAURE , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH
IPC: A61K31/343 , A61K31/282 , A61K31/513 , A61K31/519 , A61P35/00
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