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1.发明公开FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR IN COMBINATION WITH BENDAMUSTINE AND USES THEREOF 有权结合本达·马斯廷和组蛋白去乙酰化酶抑制剂配方及其用途
公开(公告)号：EP2755648A4
公开(公告)日：2015-03-11
申请号：EP11872389
申请日：2011-09-13
Applicant: PHARMACYCLICS INC , SERVIER SAS LAB
Inventor： LOURY DAVID J , BUGGY JOSEPH J , MODY TARAK D , VERNER ERIK J , PURRO NORBERT , BALASUBRAMANIAN SRIRAM , KLOOS IOANA , DEPIL STÉPHANE
IPC: A61K31/343 , A61K31/16 , A61K31/166 , A61P35/00
CPC classification number: A61K31/343 , A61K9/14 , A61K9/28 , A61K9/70 , A61K31/4184 , A61K2300/00
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2.发明专利
公开(公告)号：SG10201607620YA
公开(公告)日：2016-11-29
申请号：SG10201607620Y
申请日：2011-09-13
Applicant: PHARMACYCLICS INC , SERVIER SAS LAB
Inventor： LOURY DAVID J , BUGGY JOSEPH J , MODY TARAK D , VERNER ERIK J , PURRO NORBERT , BALASUBRAMANIAN SRIRAM , KLOOS IOANA , DEPIL STÉPHANE
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3.发明专利
公开(公告)号：AU2011376953A1
公开(公告)日：2014-03-06
申请号：AU2011376953
申请日：2011-09-13
Applicant: PHARMACYCLICS INC , SERVIER SAS LAB
Inventor： LOURY DAVID J , BUGGY JOSEPH J , MODY TARAK D , VERNER ERIK J , PURRO NORBERT , BALASUBRAMANIAN SRIRAM , KLOOS IOANA , DEPIL STEPHANE
IPC: A61K31/343 , A61K31/16 , A61K31/166 , A61P35/00
Abstract: Dosing regimens, methods of treatment, controlled release formulations, and combination therapies that include bendamustine, or a pharmaceutically acceptable salt thereof and an HDAC inhibitor, or a pharmaceutically acceptable salt thereof, are described.
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4.发明专利
公开(公告)号：SG2014014419A
公开(公告)日：2014-07-30
申请号：SG2014014419
申请日：2011-09-13
Applicant: PHARMACYCLICS INC , SERVIER SAS LAB
Inventor： LOURY DAVID J , BUGGY JOSEPH J , MODY TARAK D , VERNER ERIK J , PURRO NORBERT , BALASUBRAMANIAN SRIRAM , KLOOS IOANA , DEPIL STÉPHANE
IPC: A61K31/343 , A61K31/16 , A61K31/166 , A61P35/00
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5.发明专利
公开(公告)号：CA2845806A1
公开(公告)日：2013-03-21
申请号：CA2845806
申请日：2011-09-13
Applicant: PHARMACYCLICS INC , SERVIER SAS LAB
Inventor： LOURY DAVID J , BUGGY JOSEPH J , MODY TARAK D , VERNER ERIK J , PURRO NORBERT , BALASUBRAMANIAN SRIRAM , KLOOS IOANA , DEPIL STEPHANE
IPC: A61K31/4184 , A61K31/16 , A61K31/343 , A61K31/47 , A61P35/00
Abstract: Dosing regimens, methods of treatment, controlled release formulations, and combination therapies that include bendamustine, or a pharmaceutically acceptable salt thereof and an HDAC inhibitor, or a pharmaceutically acceptable salt thereof, are described.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2007109178A9
公开(公告)日：2008-10-16
申请号：PCT/US2007006714
申请日：2007-03-16
Applicant: PHARMACYCLICS INC , BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
Inventor： BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
IPC: A61K31/405 , C07D209/00 , C07D209/04 , C07D209/12 , C07D209/18
CPC classification number: C07D209/08 , A61K31/404 , A61K31/5377 , A61K45/06 , C07D209/12 , C07D209/14 , C07D209/42 , C07D403/06 , A61K2300/00 , A61K31/55
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
Abstract translation: 本文描述的是含有这种化合物的化合物和药物组合物，其抑制组蛋白脱乙酰酶8（HDAC8）的活性。 本文还描述了将这样的HDAC8抑制剂单独使用并与其它化合物联合用于治疗将受益于抑制HDAC8活性的疾病或病症的方法。
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7.发明申请
公开(公告)号：WO2007109178A2
公开(公告)日：2007-09-27
申请号：PCT/US2007006714
申请日：2007-03-16
Applicant: PHARMACYCLICS INC , BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
Inventor： BUGGY JOSEPH J , BALASUBRAMANIAN SRIRAM , VERNER ERICK , TAI VINCENT W-F , LEE CHANG-SUN
IPC: A61K31/55 , A61K31/405
CPC classification number: C07D209/08 , A61K31/404 , A61K31/5377 , A61K45/06 , C07D209/12 , C07D209/14 , C07D209/42 , C07D403/06 , A61K2300/00 , A61K31/55
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
Abstract translation: 本文描述的是含有这种化合物的化合物和药物组合物，其抑制组蛋白脱乙酰酶8（HDAC8）的活性。 本文还描述了将这样的HDAC8抑制剂单独使用并与其它化合物联合用于治疗将受益于抑制HDAC8活性的疾病或病症的方法。
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公开(公告)号：WO2009129335A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040709
申请日：2009-04-15
Applicant: PHARMACYCLICS INC , VERNER ERIK , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH J
Inventor： VERNER ERIK , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH J
IPC: C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14
CPC classification number: A61K45/06 , A61K31/40 , A61K31/404 , A61K31/4439 , A61K31/5377 , C07D207/337 , C07D209/08 , C07D209/12 , C07D209/14 , C07D235/06 , C07D307/79 , C07D307/80 , C07D333/54 , C07D333/56 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D471/04
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
Abstract translation: 本文描述的是含有这种化合物的化合物和药物组合物，其抑制组蛋白脱乙酰酶8（HDAC8）的活性。 本文还描述了将这样的HDAC8抑制剂单独使用并与其它化合物联合用于治疗将受益于抑制HDAC8活性的疾病或病症的方法。
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公开(公告)号：EP2265590A4
公开(公告)日：2012-04-25
申请号：EP09733489
申请日：2009-04-15
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , BALASUBRAMANIAN SRIRAM , BUGGY JOSEPH J
IPC: C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14
CPC classification number: A61K45/06 , A61K31/40 , A61K31/404 , A61K31/4439 , A61K31/5377 , C07D207/337 , C07D209/08 , C07D209/12 , C07D209/14 , C07D235/06 , C07D307/79 , C07D307/80 , C07D333/54 , C07D333/56 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D471/04
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
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10.发明公开CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 审中-公开ZIMTSÄUREHYDROXYAMIDEAS蛋白去乙酰化酶8的抑制剂
公开(公告)号：EP2797875A4
公开(公告)日：2015-09-02
申请号：EP12863933
申请日：2012-12-19
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , CHEN WEI , BALASUBRAMANIAN SRIRAM
IPC: C07C259/06 , A61K31/165 , A61P43/00 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06 , C07D405/06
CPC classification number: C07D405/06 , C07C235/34 , C07C235/38 , C07C259/06 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06
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