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公开(公告)号：NZ521154A
公开(公告)日：2004-02-27
申请号：NZ52115402
申请日：2002-09-03
Applicant: SOLVAY PHARM GMBH
Inventor： JASSERAND DANIEL , PREUSCHOFF ULF , SANN HOLGER , NTEL JOCHEN , DAVID SAMUEL , REICHE DANIA , BRUCKNER REINHARD , EECKHOUT CHRISTIAN
IPC: C07D295/12 , A61K31/341 , A61K31/381 , A61K31/496 , A61P1/00 , A61P29/00 , A61P43/00 , C07D209/08 , C07D295/08 , C07D295/084 , C07D295/092 , C07D307/52 , C07D333/20 , C07D407/04 , C07D407/06 , C07D409/06 , C07D405/14 , C07D405/06 , C07D295/13 , C07D403/06 , A61K31/495
Abstract: A compound of the general formula (I) is described, along with a process for its preparation, a medicament containing this compound, and the use of the medicament for the treatment of a functional or inflammatory disorder in the lower intestinal tract.
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公开(公告)号：HK1053648A1
公开(公告)日：2003-10-31
申请号：HK03105680
申请日：2003-08-08
Applicant: SOLVAY PHARM GMBH
Inventor： JASSERAND DANIEL , PREUSCHOFF ULF , ANTEL JOCHEN , DAVID SAMUEL , SANN HOLGER , BRUCKNER REINHARD , REICHE DANIA , EECKHOUT CHRISTIAN
IPC: C07D295/12 , A61K31/341 , A61K31/381 , A61K31/496 , A61P1/00 , A61P29/00 , A61P43/00 , C07D209/08 , C07D295/08 , C07D295/084 , C07D295/092 , C07D307/52 , C07D333/20 , C07D407/04 , C07D407/06 , C07D409/06 , C07D
Abstract: 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives (I) are new. Also new are 1-unsubstituted analog intermediates (II). 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives of formula (I) and their acid addition salts are new. A = naphthyl, phenyl (optionally substituted by OH), mono- or bi-cyclic heteroaryl or 3-6C alkenyl (optionally substituted by phenyl); Q = (CHOR1)k-(CHOR2)l-(CHOR3)m-(CHOR4)n-CH2OR5 ; R1-R5 = H or lower alkanoyl, or two of R1-R5 = CO, CS or CH2 (optionally substituted by lower alkyl or 4-5C alkylene), completing a 5- or 6-membered ring; k, l, m, n = 0 or 1, and R6, R7 = H or halo. Independent claims are also included for: (1) the preparation of (I), and (2) new piperazine derivative intermediates of formula (II).
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公开(公告)号：NO20030233L
公开(公告)日：2003-03-19
申请号：NO20030233
申请日：2003-01-17
Applicant: SOLVAY PHARM GMBH
Inventor： HEBEBRAND JOHANNES , ANTEL JOCHEN , PREUSCHOFF ULF , DAVID SAMUEL , SANN HOLGER , WESKE MICHAEL
IPC: G01N33/50 , A61K45/00 , A61P1/00 , A61P3/04 , C12Q1/02 , C12Q1/527 , G01N33/15 , C12Q1/34 , G01N33/68 , A61P3/06
Abstract: Compounds for the treatment and/or prevention of obesity are selected on the basis of their capability to inhibit de novo lipogenesis in mammals. An independent claim is also included for the use of compounds which are capable of inhibiting de novo lipogenesis in mammals and which have no anticonvulsant activity for the production of a medicament for the treatment and/or prevention of obesity. - ACTIVITY : Anorectic. - MECHANISM OF ACTION : Lipogenesis inhibitor; Carboanhydrase inhibitor. No biological data given.
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公开(公告)号：CA2403139A1
公开(公告)日：2003-03-13
申请号：CA2403139
申请日：2002-09-13
Applicant: SOLVAY PHARM GMBH
Inventor： ANTEL JOCHEN , REICHE DANIA , EECKHOUT CHRISTIAN , PREUSCHOFF ULF , JASSERAND DANIEL , BRUECKNER REINHARD , SANN HOLGER , DAVID SAMUEL
IPC: C07D295/12 , A61K31/341 , A61K31/381 , A61K31/496 , A61P1/00 , A61P29/00 , A61P43/00 , C07D209/08 , C07D295/08 , C07D295/084 , C07D295/092 , C07D307/52 , C07D333/20 , C07D407/04 , C07D407/06 , C07D409/06 , C07D407/02 , C07D409/02 , C07D241/04
Abstract: -40- Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl)- piperazine compounds which are antagonistic to tachykinin receptors, of the general formula I, wherein R6, R7, A and Z have the meanings given in the description, and medicaments containing these compounds are described. Furthermore, a process for the preparation of the novel compounds and intermediate products of this process are described.
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公开(公告)号：NO20030233D0
公开(公告)日：2003-01-17
申请号：NO20030233
申请日：2003-01-17
Applicant: SOLVAY PHARM GMBH
Inventor： HEBEBRAND JOHANNES , ANTEL JOCHEN , PREUSCHOFF ULF , DAVID SAMUEL , SANN HOLGER , WESKE MICHAEL
Abstract: Compounds for the treatment and/or prevention of obesity are selected on the basis of their capability to inhibit de novo lipogenesis in mammals. An independent claim is also included for the use of compounds which are capable of inhibiting de novo lipogenesis in mammals and which have no anticonvulsant activity for the production of a medicament for the treatment and/or prevention of obesity. - ACTIVITY : Anorectic. - MECHANISM OF ACTION : Lipogenesis inhibitor; Carboanhydrase inhibitor. No biological data given.
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Patent Agency Ranking
公开(公告)号：NZ331524A
公开(公告)日：2000-02-28
申请号：NZ33152498
申请日：1998-08-24
Applicant: SOLVAY PHARM GMBH
Inventor： JASSERAND DANIEL , DAVID SAMUEL , ANTEL JOCHEN , BRUCKNER REINHARD , EECKHOUT CHRISTIAN , BIELENBERG GERHARD-WILHELM
IPC: C07D403/06 , A61K31/495 , A61K31/496 , A61P1/00 , A61P29/00 , A61P43/00 , C07D209/00 , C07D209/14 , C07D241/00 , A61K31/445
Abstract: Urea derivatives of the formula 1 are distinguished by properties antagonistic to neurokinin receptors with an action profile beneficial for the treatment of functional and inflammatory disorders of the gastrointestinal tract of large animals where R1 is H or lower alkyl R2 is H or halogen R3 is H or lower alkoxy and a physiologically compatible acid addition salt thereof. Also claimed is a pharmaceutical composition comprising the above formula, process for making and use for treating a pathological condition in which a neurokinin is involved as transfer agent.
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公开(公告)号：TR9801681A2
公开(公告)日：1999-03-22
申请号：TR9801681
申请日：1998-08-27
Applicant: SOLVAY PHARM GMBH
Inventor： DAVID SAMUEL , ANTEL JOCHEN , BRUECKNER REINHARD , ZIEGLER DIETER , EECKHOUT CHIRISTIAN , BIELENBERG GERHARD-WILHELM , PECK MICHAEL
CPC classification number: C07D243/08 , Y02P20/55
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公开(公告)号：ID20787A
公开(公告)日：1999-03-04
申请号：ID981171
申请日：1998-08-27
Applicant: SOLVAY PHARM GMBH
Inventor： JASSERAND DANIEL , DAVID SAMUEL , ANTEL JOCHEN , BRUCKNER REINHARD , EECKHOUT CHRISTIAN , BIELENBERG GERHARD-WILHELM
IPC: C07D403/06 , A61K31/495 , A61K31/496 , A61P1/00 , A61P29/00 , A61P43/00 , C07D209/00 , C07D209/14 , C07D241/00 , F23R3/40
Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.
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公开(公告)号：ZA986721B
公开(公告)日：1999-02-02
申请号：ZA986721
申请日：1998-07-28
Applicant: SOLVAY PHARM GMBH
Inventor： JASSERAND DANIEL , DAVID SAMUEL , ANTEL JOCHEN , BRUCKNER REINHARD , EECKHOUT CHRISTIAN , BIELENBERG GERHARD-WILHELM
IPC: C07D403/06 , A61K31/495 , A61K31/496 , A61P1/00 , A61P29/00 , A61P43/00 , C07D209/00 , C07D209/14 , C07D241/00 , C07D , A61K
Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.
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公开(公告)号：ZA9806721B
公开(公告)日：1999-02-02
申请号：ZA9806721
申请日：1998-07-28
Applicant: SOLVAY PHARM GMBH
Inventor： JASSERAND DANIEL , DAVID SAMUEL , ANTEL JOCHEN , BRUCKNER REINHARD , EECKHOUT CHRISTIAN , BIELENBERG GERHARD-WILHELM
IPC: C07D403/06 , A61K31/495 , A61K31/496 , A61P1/00 , A61P29/00 , A61P43/00 , C07D209/00 , C07D209/14 , C07D241/00 , C07D , A61K
CPC classification number: C07D209/14 , Y02P20/55
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