公开(公告)号：AU2709901A

公开(公告)日：2001-07-31

申请号：AU2709901

申请日：2001-01-24

Applicant: UBE INDUSTRIES ,  NISSAN CHEMICAL IND LTD

Inventor： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  OKADA NAOKO ,  SHIMA HIDETAKA ,  HARADA TAKASHI

IPC: C07D215/12 ,  C07D215/14

Abstract: 3-Ä2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜprop-2-enenitrite is prepared by reacting 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base and then adding a dehydrating to the reaction mixture to conduct dehydration. Under ordinary conditions, novel 3-Ä2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylÜ-3-hydroxypropionitrile is formed as an intermediate in the above reaction. Incidentally, when the above reaction is conducted in an organic solvent, 3-Ä2-cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜ-prop-2-enenitrite is directly formed.

公开(公告)号：EP2123627A4

公开(公告)日：2010-07-21

申请号：EP07707070

申请日：2007-01-19

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  SHIMA HIDETAKA ,  ODA HIROYUKI

IPC: C07C213/02 ,  C07B61/00 ,  C07C217/86 ,  C07C219/34 ,  C07D213/73

CPC classification number: C07D213/73 ,  C07C213/02 ,  C07C217/86

公开(公告)号：EP1251123A4

公开(公告)日：2003-02-05

申请号：EP01901537

申请日：2001-01-24

Applicant: UBE INDUSTRIES ,  NISSAN CHEMICAL IND LTD

Inventor： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  OKADA NAOKO ,  SHIMA HIDETAKA ,  HARADA TAKASHI

IPC: C07D215/12 ,  C07D215/14

CPC classification number: C07D215/12

Abstract: 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile is prepared by reacting 2-cyclopropyl-4- (4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base and then adding a dehydrating agent to the reaction mixture to conduct dehydration. Under ordinary conditions, novel 3-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3-hydroxypropionitrile is formed as an intermediate in the above reaction. Incidentally, when the above reaction is conducted in an organic solvent, 3-[2- cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile is directly formed.

公开(公告)号：EP1661894A4

公开(公告)日：2007-02-28

申请号：EP04747476

申请日：2004-07-14

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  IWAMOTO KEIJI ,  HARADA TAKASHI ,  SUZUKI SHINOBU

IPC: C07D309/14 ,  C07B61/00 ,  C07D309/10

CPC classification number: C07D309/10 ,  C07D309/14

Abstract: A process for the production of 4-aminotetrahydropyrans represented by the general formula (2) and salts thereof with acids: [wherein R is hydrogen or a hydrocarbon group], characterized by subjecting a 4-hydrazinotetrahydropyran represented by the general formula (1) or a salt thereof with an acid: [wherein R is as defined above] to decomposition in the presence of at least one compound selected from among Raney nickel, noble metal catalysts, and metal oxides; intermediates for the process; and a process for the production of the intermediates.

公开(公告)号：EP1650196A4

公开(公告)日：2007-02-28

申请号：EP04748126

申请日：2004-07-30

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  ODA HIROYUKI ,  SUZUKI SHINOBU

IPC: C07D239/88 ,  C07C67/31

CPC classification number: C07D239/88 ,  C07C67/31 ,  C07C69/92

Abstract: [PROBLEMS] A process for obtaining 6,7-bis(2-methoxyethoxy)­quinazolin-4-one in a high yield from ethyl 2-amino-4,5­bis(2-methoxyethoxy)benzoate. [MEANS FOR SOLVING PROBLEMS] The process for producing 6,7-bis(2-methoxyethoxy)quinazolin-4-one comprises reacting ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate with a formic acid compound in the presence of an ammonium carboxylate.

公开(公告)号：EP3064489A4

公开(公告)日：2017-06-21

申请号：EP14857120

申请日：2014-11-04

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  SHIMA HIDETAKA ,  ODA HIROYUKI ,  SHIMANO TETSURO

IPC: C07C381/00 ,  A61K31/167 ,  A61K31/216 ,  A61K31/36 ,  A61P1/02 ,  A61P3/06 ,  A61P3/10 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P19/02 ,  A61P19/10 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/04

CPC classification number: C07C381/00 ,  A61K31/167 ,  A61K31/216 ,  A61K31/36 ,  C07D207/327 ,  C07D207/34 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D231/14 ,  C07D233/90 ,  C07D237/24 ,  C07D239/28 ,  C07D239/34 ,  C07D241/24 ,  C07D263/34 ,  C07D277/56 ,  C07D307/68 ,  C07D311/16 ,  C07D317/60 ,  C07D333/38

Abstract: Provided is an aryloyl(oxy or amino)pentafluorosulfanylbenzene compound having pharmacological action. The present invention relates to an aryloyl(oxy or amino)pentafluorosulfanylbenzene compound represented by general formula (A-I), a pharmaceutically acceptable salt thereof, and a prodrug thereof; wherein all of parameters represent the same meanings as defined in the specification.

Abstract translation: 提供具有药理作用的芳酰基（氧或氨基）五氟硫烷基苯化合物。 本发明涉及由通式（A-I）表示的芳酰基（氧或氨基）五氟硫烷基苯化合物，其药学上可接受的盐及其前药; 其中所有参数表示与说明书中定义的相同的含义。

公开(公告)号：EP2829542A4

公开(公告)日：2015-08-26

申请号：EP13765244

申请日：2013-03-15

Applicant: UBE INDUSTRIES

Inventor： TOKITO SHIZUO ,  KUMAKI DAISUKE ,  SHIMA HIDETAKA ,  ODA HIROYUKI ,  TANAKA YASUHIRO ,  KAKITA KAZUAKI ,  MACHIDA TOSHIKAZU ,  YONEDA YASUHIRO ,  OMATA YOUJI ,  SHIMANO TETSURO

IPC: C07D513/04 ,  C09D11/00 ,  H01L29/786 ,  H01L51/05 ,  H01L51/30 ,  H01L51/50

CPC classification number: C07D513/04 ,  C08G61/123 ,  C08G61/126 ,  C08G2261/1642 ,  C08G2261/1644 ,  C08G2261/3223 ,  C08G2261/3246 ,  C08G2261/364 ,  C08G2261/414 ,  C08G2261/51 ,  C08G2261/91 ,  C08G2261/92 ,  C08G2261/95 ,  C09B57/00 ,  C09D11/52 ,  H01L27/3274 ,  H01L51/0071 ,  H01L51/0097 ,  H01L51/0545 ,  H01L51/42 ,  H01L51/5012 ,  H01L51/5056 ,  H01L51/5072 ,  H01L2251/5338 ,  Y02E10/549

Abstract: The present invention relates to a benzobis(thiadiazole) derivative represented by the formula (1): wherein R represents a group containing at least one fluorine atom (with the proviso that fluorine atom (F) and trifluoromethyl group (-CF 3 ) are excluded), and m represents an integer of from 1 to 10.

公开(公告)号：EP1247807A4

公开(公告)日：2003-02-12

申请号：EP00980002

申请日：2000-12-08

Applicant: UBE INDUSTRIES

Inventor： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  SHIMA HIDETAKA ,  NISHIMURA MINORU ,  HIROTSU KENJI

IPC: C07D309/08 ,  C07D309/14

CPC classification number: C07D309/14 ,  C07D309/08

Abstract: A process for producing a tetrahydropyranyl-4-sulfonate characterized by reacting 3-buten-1-ol, which is easily available, with a formaldehyde compound and an organic sulfonic acid; and a process suitable for the industrial production of a 4-aminotetrahydropyran derivative, by which the derivative can be produced in high yield under mild conditions through a simple procedure.

Abstract translation: 一种制备四氢吡喃基-4-磺酸酯的方法，其特征在于使容易获得的3-丁烯-1-醇与甲醛化合物和有机磺酸反应; 以及适用于4-氨基四氢吡喃衍生物的工业生产的方法，通过该方法可以在温和条件下通过简单的程序高产率地制备衍生物。

公开(公告)号：EP3048107A4

公开(公告)日：2017-05-31

申请号：EP14845080

申请日：2014-08-29

Applicant: UBE INDUSTRIES

Inventor： TOKITO SHIZUO ,  KUMAKI DAISUKE ,  MAMADA MASASHI ,  FUKUDA KENJIRO ,  TANAKA YASUHIRO ,  SHIMA HIDETAKA ,  YONEDA YASUHIRO ,  FUJITA HARUNORI ,  KAKITA KAZUAKI ,  OMATA YOUJI ,  YAMADA NATSUKO ,  HONMA TAKASHI ,  MACHIDA TOSHIKAZU

IPC: H01L51/30 ,  C07D513/02 ,  C07D513/04 ,  C09D11/52 ,  H01L27/32 ,  H01L29/786 ,  H01L51/46 ,  H01L51/54

CPC classification number: H01L51/0071 ,  C07D513/02 ,  C07D513/04 ,  C09D11/52 ,  H01L27/3274 ,  H01L51/0068 ,  H01L51/0097 ,  H01L51/0558 ,  H01L51/0566 ,  H01L51/4253 ,  H01L51/5056 ,  H01L51/5072 ,  Y02E10/549

Abstract: The present invention relates to a benzobis(thiadiazole) derivative represented by the following general formula (1): wherein R 1 represents a linear or branched alkyl group, or any one of the groups of the following formula (2): wherein R represents a linear or branched alkyl group; R 2 represents a hydrogen atom; and R 3 represents a hydrogen atom, a linear or branched alkyl group, or any one of the groups of the formula (2); with the proviso that at least one of R 1 and R 3 represents any one of the groups of the formula (2); and two R 1 groups, two R 2 groups, and two R 3 groups may be the same as, or different from each other.

Abstract translation: 本发明涉及下述通式（1）所示的苯并双（噻二唑）衍生物，式中，R 1表示直链状或支链状的烷基或下述式（2）的基团中的任一种：式中，R表示 直链或支链烷基; R 2代表氢原子; 并且R 3表示氢原子，直链或支链烷基或式（2）的任何一个基团; 条件是R 1和R 3中的至少一个表示式（2）的任何一个基团; 并且两个R 1基团，两个R 2基团和两个R 3基团可以彼此相同或不同。

公开(公告)号：EP1700853A4

公开(公告)日：2009-07-22

申请号：EP04807306

申请日：2004-12-17

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  SUZUKI SHINOBU

IPC: C07D309/30 ,  B01J23/44 ,  B01J37/00 ,  C07C45/45 ,  C07C49/185 ,  C07D309/38

CPC classification number: C07D309/38 ,  C07C45/00 ,  C07C49/185 ,  C07D309/30

Abstract: A process for producing tetrahydropyran-4-one, which is represented by the formula (1), characterized by reacting at least one of dihydropyran-4-one and pyran-4-one, which are represented by the formula (2): (2) (wherein (A) indicates a single bond or double bond), with hydrogen either (a) in a mixed solvent comprising an aprotic solvent and an alcohol solvent in the presence of a metal catalyst or (b) in a hydrophobic organic solvent in the presence of an anhydrous metal catalyst obtained by dehydrating a hydrous metal catalyst.