-
公开(公告)号：NZ563539A
公开(公告)日：2011-04-29
申请号：NZ56353906
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMAN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Provided is an antibody or functional fragment thereof that cross-blocks or is cross-blocked from binding of at least one of antibodies Ab-A, Ab-1, Ab-4, Ab-5, Ab-19, Ab-20, and Ab-23 to sclerostin. The antibodies are useful for treating bone-related disorders in mammals.
-
公开(公告)号：ZA200709480B
公开(公告)日：2010-07-28
申请号：ZA200709480
申请日：2007-11-02
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , GRAHAM KEVIN , HOFFMAN KELLY SUE , LAWSON ALASTAIR , POPPLEWELL ANDY , WINKLER DAVID G , ROBINSON MARTYN KIM , HENRY ALISTAIR JAMES , LATHAM JOHN , LU HSIENG SEN , SHEN WENYAN , WINTERS AARON GEORGE
IPC: C07K20060101
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
-
公开(公告)号：ECSP099683A
公开(公告)日：2009-12-28
申请号：ECSP099683
申请日：2009-10-08
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： POPPLEWELL ANDREW GEORGE , BROWN DEREK THOMAS , ADAMS RALPH , FERRANT-ORGETTAS JANINE L , GARBER ELLEN A , HSU YEN-MING , SU LIHE , TAYLOR FREDERICK R , ROBINSON MARTYN KIM , SHOCK ANTHONY , TYSON KERRY LOUISE
Abstract: Esta invención proporciona proteínas de unión, que incluyen anticuerpos, derivados de anticuerpo, y fragmentos de anticuerpo, que específicamente se unen a la proteína CD154 (CD40L). Esta invención también proporciona un anticuerpo quimérico, humanizado o completamente humano, derivado de anticuerpo o fragmento de anticuerpo que específicamente se une a un epítopo al cual se une un fragmento Fab humanizado que comprende una secuencia de cadena pesada variable de acuerdo con SEC ID NO: 1 y comprende una secuencia de cadena ligera variable de acuerdo con SEC ID NO: 2. Las proteínas de unión CD154 de esta invención pueden producir una función efectora reducida con relación a un segundo anticuerpo anti-CD154. Las proteínas de unión CD154 de la invención son útiles en métodos de diagnóstico y terapéuticos, tales como en el tratamiento y prevención de enfermedades que incluyen las que involucran respuestas inmunitarias indeseables que están mediadas por las interacciones de CD154-CD40
-
公开(公告)号：AU2003301318B2
公开(公告)日：2008-09-04
申请号：AU2003301318
申请日：2003-10-15
Applicant: UCB PHARMA SA
Inventor： CHAPMAN ANDREW PAUL , HUMPHREYS DAVID PAUL , ROBINSON MARTYN KIM , SPITALI MARIANGELA
IPC: C12N1/20 , C07K14/245 , C12N1/21 , C12N15/31
Abstract: The present invention provides an E. coli host cell expressing a recombinant antibody characterized in that the E. coli host cell has been genetically modified in order to change at least one physical property of one or more E. coli proteins which in the wild type co-purify with said recombinant antibody.
-
公开(公告)号：NO20076046L
公开(公告)日：2008-01-30
申请号：NO20076046
申请日：2007-11-23
Applicant: UCB PHARMA SA
Inventor： LATHAM JOHN , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: C07K14/51 , C07K14/435 , C07K16/18 , C07K16/28
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
-
Patent Agency Ranking
公开(公告)号：CA2607197A1
公开(公告)日：2006-11-09
申请号：CA2607197
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： WINTERS AARON GEORGE , LATHAM JOHN , HOFFMANN KELLY SUE , WINKLER DAVID , LAWSON ALASTAIR , LU HSIENG SEN , HENRY ALISTAIR JAMES , SHEN WENYAN , ROBINSON MARTYN KIM , GRAHAM KEVIN , PASZTY CHRISTOPHER , POPPLEWELL ANDY
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
-
公开(公告)号：RS62685B1
公开(公告)日：2021-12-31
申请号：RSP20211488
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
-
公开(公告)号：UA123695C2
公开(公告)日：2021-05-19
申请号：UAA201202580
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Винахідналежитьдополіпептиду, щоявляєсобоюепітопбілкасклеростинулюдини, способуодержанняантитіла, якезв’язуєвказанийепітоп, антитіла, здатногозв'язуватисяізвказанимепітопомсклеростину, виділеногополінуклеотиду, клонуючогоабоекспресуючоговектора, клітини-хазяїна, фармацевтичноїкомпозиції, застосуванняфармацевтичноїкомпозиціїдлялікуванняпорушення, опосередкованогопідвищенимрівнемсклеростинутадіагностичногонабору, щоміститьзазначенеантитіло.
-
公开(公告)号：AU2012238247B2
公开(公告)日：2016-06-16
申请号：AU2012238247
申请日：2012-10-08
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： WINTERS AARON GEORGE , LAWSON ALASTAIR , HENRY ALISTAIR JAMES , POPPLEWELL ANDY , PASZTY CHRISTOPHER , SHEN WENYAN , LU HSIENG SEN , LATHAM JOHN , HOFFMANN KELLY SUE , GRAHAM KEVIN , ROBINSON MARTYN KIM , WINKLER DAVID
Abstract: C:\NRPorbl\DCCSZPWA6573 I DOC.4/10/2012 Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided. 4v Lu L % 6 Iii cc ~ O O. . .U te,, Lo~ .CD C; L 0ZDB aweI
-
公开(公告)号：GEP20166454B
公开(公告)日：2016-04-11
申请号：GEAP2006012335
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: An invention relates to antibodies binding sclerostin epitopes, which crossly block Ab-C, Ab-D, Ab-13 or Ab-14 binding with sclerostin sequ¬ences SEQ ID NO: 1. Said antibodies are applied at the treatment of diseases related to abnormalities in bone mineral density and of bone mass.
-
-
-
-
-
-
-
-
-
Search Results
66
records
(took 0.022 seconds)
