445.
    发明专利
    未知

    公开(公告)号:AT470725T

    公开(公告)日:2010-06-15

    申请号:AT05855433

    申请日:2005-12-21

    Abstract: We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

    448.
    发明专利
    未知

    公开(公告)号:AT452978T

    公开(公告)日:2010-01-15

    申请号:AT07100073

    申请日:2007-01-03

    Abstract: Disclosed are nucleic acids encoding fusion polypeptides containing the sequence of a Bamboo mosaic virus coat protein or a segment thereof; and an immunogenic heterologous fragment that is fused to the carrier fragment. Also disclosed are related chimeric bamboo mosaic virus particle, related expression vectors, related host cells, and related compositions. Methods of producing and using the fusion polypeptide or chimeric Bamboo mosaic virus particle are also disclosed.

    Genetic variants of vkorc1 predicting warfarin sensitivity

    公开(公告)号:NZ556461A

    公开(公告)日:2009-12-24

    申请号:NZ55646105

    申请日:2005-12-21

    Abstract: Disclosed is a method of determining the dose range of warfarin for a subject, comprising investigating the single nucleotide polymorphism (SNP) at the 3673 position of SEQ ID NO: 1 in the subject, determining whether the subject is warfarin sensitive or resistant based on the SNP at the 3673 position, wherein homozygous AA, heterozygous AG, and homozygous GG at this position indicate that the patient is warfarin sensitive, intermediate sensitive, and resistant, respectively; and predicting a warfarin dosage range based on the warfarin sensitivity/resistance of the subject.

Patent Agency Ranking