公开(公告)号：DE69121883T2

公开(公告)日：1997-03-06

申请号：DE69121883

申请日：1991-12-23

Applicant: DADE MICROSCAN INC

Inventor： BADAL ROBERT ,  KELLEY ROGER ,  SAND THEODORE ,  BASCOMB SHOSHANA

IPC: C12Q1/04 ,  C12Q1/18

公开(公告)号：EP1236513A1

公开(公告)日：2002-09-04

申请号：EP02003203.3

申请日：2002-02-19

Applicant: Dade MicroScan Inc.

Inventor： Farina, Edward Francis ,  Ferguson, Samuel Garfield, Jr. ,  Gebrian, Peter Louis ,  Krufka, Frank Stephen ,  Mazza, John Charles ,  Shmel, Nicholas Michael, Jr.

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01L3/502723 ,  B01L2200/0684 ,  B01L2200/142 ,  B01L2300/0864 ,  B01L2400/049

Abstract: A microbiological test array with a generally flat base having a plurality of upwardly projecting microwells connected by a microchannel to an open reservoir formed in a top surface generally parallel to the base of the test array. The reservoir has an opening to permit an inoculum-broth liquid solution to flow from the reservoir through the microchannel, to a sacrificial evaporation well having an air vent port adapted to control a vacuum filling process, and subsequently to be distributed into each of the plurality of microwells.

Abstract translation: 具有大致平坦基底的微生物测试阵列，其具有多个向上突出的微孔，其通过微通道连接到形成在大体上平行于测试阵列的基部的顶表面中的开放储存器。 储存器具有允许接种物 - 液体液体溶液从储存器通过微通道流动到具有适于控制真空填充过程的排气口的牺牲蒸发井的开口，并且随后分配到多个 的微孔。

公开(公告)号：EP0525181B1

公开(公告)日：1997-08-06

申请号：EP92907537.2

申请日：1992-02-10

Applicant: Dade MicroScan Inc.

Inventor： SHERMAN, David, Gordon ,  BUSH, Charlene, Eleanor ,  BENINSIG, Laura, Ann ,  VANDENBRINK, Kurt, Mathew

IPC: C12Q1/68 ,  C07H21/00

CPC classification number: A61K49/0054 ,  A61K49/0019 ,  C07H21/00 ,  C07H23/00 ,  C12Q1/6816 ,  G01N2458/40 ,  C12Q2565/627 ,  C12Q2563/137 ,  C12Q2563/107

Abstract: Rare earth chelate-conjugated oligonucleotides useful in nucleic acid hybridization assays and for generating chelate-labelled probes of any desired sequence are disclosed. The particular class of chelates utilized exhibit an unusually high efficiency of rare earth element capture, correlated with emission of a high level of signal in time-resolved fluorescence spectroscopy compared to other structurally related chelate compounds.

公开(公告)号：EP0516814B1

公开(公告)日：1996-09-04

申请号：EP92902996.5

申请日：1991-12-23

Applicant: Dade MicroScan Inc.

Inventor： BADAL, Robert ,  KELLEY, Roger ,  SAND, Theodore, T. ,  BASCOMB, Shoshana

IPC: C12Q1/18

CPC classification number: C12Q1/04 ,  C12Q1/18 ,  C12Q2337/22 ,  Y10S435/968 ,  Y10S436/80

Abstract: This invention relates to a method to determine susceptibility to antimicrobial agents of a majority of clinically significant Gram positive organisms. This invention also relates to a mixture of fluorogenic substrates used to detect the growth of Gram positive Bacteria.

公开(公告)号：EP0525825A3

公开(公告)日：1993-04-07

申请号：EP92116023.0

申请日：1986-03-18

Applicant: Dade MicroScan Inc.

Inventor： Hale, Ron L. ,  Solas, Dennis W.

IPC: C07D213/79 ,  G01N33/533

CPC classification number: C07D213/79 ,  C07D213/38 ,  C07D405/14 ,  C07D473/08 ,  G01N33/533 ,  Y10S436/80

Abstract: Disclosed are substituted aryl-substituted 2,6-dicarboxy pyridine compounds of general formula

wherein Ar represents aryl, n" is an integer equal to the number of available bonding sites on Ar, each of the n" Rs, R' and R" are independently selected from hydrogen; electron-releasing groups including C 1 -C 4 alkoxy, C 1 -C 4 alkyl, amino, dialkylamino, aryl and aryloxy groups; and linking groups; and R * and R** are independently selected from metal ions, hydrogen and C 1 -C 4 alkyl groups. Said compounds are useful precursors for fluorescently detectable molecules comprising a substituted aryl-substituted 2,6-bis[N,N-di(carboxyalkyl)aminoalkyl]pyridine moiety.

公开(公告)号：EP0525825A2

公开(公告)日：1993-02-03

申请号：EP92116023.0

申请日：1986-03-18

Applicant: Dade MicroScan Inc.

Inventor： Hale, Ron L. ,  Solas, Dennis W.

IPC: C07D213/79 ,  G01N33/533

CPC classification number: C07D213/79 ,  C07D213/38 ,  C07D405/14 ,  C07D473/08 ,  G01N33/533 ,  Y10S436/80

Abstract: Disclosed are substituted aryl-substituted 2,6-dicarboxy pyridine compounds of general formula

wherein Ar represents aryl, n" is an integer equal to the number of available bonding sites on Ar, each of the n" Rs, R' and R" are independently selected from hydrogen; electron-releasing groups including C 1 -C 4 alkoxy, C 1 -C 4 alkyl, amino, dialkylamino, aryl and aryloxy groups; and linking groups; and R * and R** are independently selected from metal ions, hydrogen and C 1 -C 4 alkyl groups.
Said compounds are useful precursors for fluorescently detectable molecules comprising a substituted aryl-substituted 2,6-bis[N,N-di(carboxyalkyl)aminoalkyl]pyridine moiety.

Abstract translation: 公开了通式为CHEM的取代的芳基取代的2,6-二羧基吡啶化合物，其中Ar表示芳基，n“是等于Ar上可用键合位点数的整数，n”Rs，R '和R“独立地选自氢; 包括C1-C4烷氧基，C1-C4烷基，氨基，二烷基氨基，芳基和芳氧基的电子释放基; 和连接组; R *和R **独立地选自金属离子，氢和C 1 -C 4烷基。 所述化合物是包含取代的芳基取代的2,6-二[N，N-二（羧基烷基）氨基烷基]吡啶部分的荧光检测分子的有用前体。

公开(公告)号：EP1381451A1

公开(公告)日：2004-01-21

申请号：EP02764180.2

申请日：2002-04-08

Applicant: Dade MicroScan Inc.

Inventor： GEBRIAN, Peter, Louis

IPC: B01F13/08

CPC classification number: B01F7/005 ,  B01F13/0818 ,  B01F2215/0037

Abstract: Mixing a liquid solution (18) in a container (14) by revolving a pair of magnets (12) in close proximity to and on opposite sides of the container a distance above the bottom of the container causing a magnetic mixing member (16) to rotate in the liquid about the same distance above the bottom of the container.

公开(公告)号：EP1335971A1

公开(公告)日：2003-08-20

申请号：EP02756966.4

申请日：2002-07-30

Applicant: Dade MicroScan Inc.

Inventor： GEMMELL, Bruce, McLean ,  MAZZA, John, Charles ,  GEBRIAN, Peter, Louis ,  SHMEL, Nicholas, Michael, Jr. ,  FARINA, Edward, Frances ,  VAIDYA, Hemant

IPC: C12M1/34

CPC classification number: G01N35/0092 ,  G01N35/025 ,  G01N35/026 ,  G01N2035/00049 ,  G01N2035/00148 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0446 ,  G01N2035/0465

Abstract: A random access microbiological analyzer (10) for performing AST and ID tests on samples using on-board inventories of different AST test arrays (12) and different ID test rotors (16) within separate AST and ID incubation and analysis chambers (22, 28).

公开(公告)号：EP0538447B1

公开(公告)日：1997-05-28

申请号：EP92911242.3

申请日：1992-04-29

Applicant: Dade MicroScan Inc.

Inventor： JOHNSTON, Judith ,  FELLAND, Tracy ,  BASCOMB, Shoshana ,  GODSEY, James, H.

IPC: C12Q1/02 ,  C12Q1/18 ,  C12Q1/20 ,  C12N1/38 ,  C12Q1/34

CPC classification number: C12Q1/18 ,  Y10S435/975

Abstract: In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamase inducing antibiotic and a beta-lactam indicator antibiotic which kills or inhibits the growth of bacteria unable to hydrolyze beta-lactam antibiotics. Growth, indicative of drug resistance in the target strain, is monitored by detecting a fluorophor released by the enzymatic cleavage of a metabolizable fluorogenic compound.

公开(公告)号：EP1346024A2

公开(公告)日：2003-09-24

申请号：EP02789157.1

申请日：2002-07-30

Applicant: Dade MicroScan Inc.

Inventor： FARINA, Edward, Frances ,  GEBRIAN, Peter, Louis ,  MAZZA, John, Charles ,  CAMERON, Allan, Lee ,  MUDD, Alan, Christopher ,  O'BRIEN, Richard ,  SWETT, David, Orrin ,  WEST, Adrian, Mark, Thomas

IPC: C12M1/24

CPC classification number: B01L9/50 ,  B01F13/0818 ,  B01L3/508 ,  B01L2200/025 ,  B01L2300/0848

Abstract: A cup-like broth container (242) comprising four mutually opposed pairs of connected sidewalls (250) with a protruding rib (248) formed on each of four perpendicularly opposed single sidewalls and four Y-shaped clamping ridges (252) attached to and extending outwardly from a single one of the four sidewalls located between the four sidewalls having a protruding rib.