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    MEASUREMENT OF ANALYTE WITH AN ACOUSTIC WAVE SENSOR
    41.
    发明申请
    MEASUREMENT OF ANALYTE WITH AN ACOUSTIC WAVE SENSOR 审中-公开
    用声波传感器测量分析仪

    公开(公告)号：WO2017005663A1

    公开(公告)日：2017-01-12

    申请号：PCT/EP2016/065612

    申请日：2016-07-01

    Applicant: FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

    Inventor： PAPADAKIS, George ,  GIZELI, Electra

    IPC: G01N29/02 ,  G01N29/032 ,  C12Q1/68 ,  G01N29/036 ,  G01N33/543

    CPC classification number: G01N29/022 ,  C12Q1/6825 ,  C12Q2565/634 ,  G01N29/032 ,  G01N29/036 ,  G01N33/54373 ,  G01N33/586 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0257 ,  G01N2291/0426 ,  C12Q2525/197

    Abstract: A sensitive assay for an analyte employing an acoustic wave sensor. A label which has a higher dissipative capacity than the analyte is adhered to the sensing surface of an acoustic wave sensor through the analyte such that the body of the label is spaced apart from and anchored to the surface of the acoustic wave sensor by a distance of 15 to 250nm. The change in the energy losses or the frequency or phase of the acoustic wave when the label binds to the sensing surface is used to measure the presence or amount of the label. A substantial improvement in the detection limit of the label is obtained. The analyte may for example be a nucleic acid and the label may for example comprise liposomes.

    Abstract translation: 使用声波传感器的分析物的敏感测定。 具有比分析物更高的耗散能力的标签通过分析物粘附到声波传感器的感测表面，使得标签的主体与声波传感器的表面间隔开并锚定在声波传感器的表面上 15至250nm。 当标签与感测表面结合时，能量损失或声波频率或相位的变化用于测量标签的存在或数量。 获得标签检测限的实质性改进。 分析物可以例如是核酸，并且标记可以例如包括脂质体。

    TRANSGENIC ANIMAL
    42.
    发明申请
    TRANSGENIC ANIMAL 审中-公开
    转基因动物

    公开(公告)号：WO2014023672A1

    公开(公告)日：2014-02-13

    申请号：PCT/EP2013/066341

    申请日：2013-08-03

    Applicant: FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS - FORTH

    Inventor： MAVROTHALASSITIS, George

    IPC: A01K67/027 ,  C07K14/47

    CPC classification number: A01K67/0276 ,  A01K2217/054 ,  A01K2217/075 ,  A01K2217/20 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  C07K14/4703 ,  C12N15/8509

    Abstract: The present invention concerns a non-human transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of Erf expression and/or ERF activity which is reduced compared to a wildtype animal, wherein said animal has a defect in ossification. Further provided is a non-human transgenic animal comprising an insertion of a promoter-marker gene cassette in one or both Erf alleles wherein the cassette is present in an intron of Erf and wherein said animal exhibits an expression level of Erf and/or ERF activity which is reduced compared to a wildtype animal. Uses of these animals and of a non-human transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of expression of Erf and/or ERF activity which is reduced compared to a wildtype animal for producing animals with ossification defects, for identifying treatments and as disease models are encompassed.

    Abstract translation: 本发明涉及一种非人转基因动物，其包含其基因组中的修饰，其导致动物表现出与野生型动物相比降低的Erf表达和/或ERF活性水平，其中所述动物具有骨化缺陷。 还提供了非人转基因动物，其包括在一个或两个Erf等位基因中插入启动子 - 标记基因盒，其中所述盒存在于Erf的内含子中，并且其中所述动物表现出Erf和/或ERF活性的表达水平 其与野生型动物相比减少。 这些动物和非人转基因动物的使用在其基因组中包含修饰，导致动物表现出与用于产生具有骨化缺陷的动物有关的野生型动物的Erf和/或ERF活性的表达水平， 用于识别治疗并且包括疾病模型。

    SELF HEATING PACKAGING AND METHOD OF MANUFACTURING FUEL
    43.
    发明申请
    SELF HEATING PACKAGING AND METHOD OF MANUFACTURING FUEL 审中-公开
    自加热包装和制造燃料的方法

    公开(公告)号：WO2011124910A2

    公开(公告)日：2011-10-13

    申请号：PCT/GB2011/050675

    申请日：2011-04-05

    Applicant: NANO HEATING COMPANY LIMITED ,  FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS, INSTITUTE OF CHEMICAL ENGINEERING AND HIGH TEMPERATURE CHEMICAL PROCESSES ,  SEARLE, Matthew ,  DELIMARIS, Dimitrios ,  IOANNIDES, Theophilos

    Inventor： SEARLE, Matthew ,  DELIMARIS, Dimitrios ,  IOANNIDES, Theophilos

    IPC: C09K5/00

    CPC classification number: C10L8/00 ,  B65D81/3484 ,  C09K5/18

    Abstract: A method of making a fuel for a portable heater comprises heating a salt of iron with a carboxylic acid at a temperature from about 400 o C to about 700 o C under an inert or reducing atmosphere to produce a composite material comprising carbon and iron nanoparticles. The fuel may be mounted to a substrate, such as a mesh or foil, and incorporated into a self-heating packaging. Typically, the packaging comprises a wall defining a chamber that, in use, contains a substance to be heated, e.g. a foodstuff or liquid. A heating manifold in thermal communication with the chamber contains the fuel in the inert atmosphere to initially inhibit production of heat otherwise arising from substantial oxidation of substantially all the fuel in the manifold in an exothermic reaction. A vent in the manifold is initially sealed and air-tight, but selectively opening of the vent allows oxidation of the iron nanoparticles. The chamber is then heated by the transfer of heat from the fuel to the chamber, the transfer of heat being by at least one of direct thermal conduction through the wall, thermal convection or indirect thermal heating arising from heating of a fluid medium that is introduced into the chamber.

    Abstract translation: 制造便携式加热器的燃料的方法包括在约400℃至约700℃的温度下将铁盐与羧酸加热 在惰性气氛或还原气氛下制备包含碳和铁纳米颗粒的复合材料。 燃料可以被安装到诸如网或箔的基底上，并且被结合到自加热包装中。 通常，包装包括限定腔室的壁，在使用中该腔室包含待加热的物质，例如， 食物或液体。 与腔室热连通的加热歧管包含惰性气氛中的燃料，以最初抑制否则由于放热反应中歧管中的基本上所有燃料的实质氧化而产生的热量。 歧管中的通气孔初始密封且气密，但选择性地打开通气孔允许氧化铁纳米颗粒。 然后通过将热量从燃料传递到腔室来加热腔室，热量的传递通过直接热传导穿过壁，热对流或由引入的流体介质的加热引起的间接热加热 进入房间。

    APPARATUSES, METHODS AND SYSTEMS FOR ESTIMATING WATER DIFFUSIVITY AND MICROCIRCULATION OF BLOOD USING DW-MRI DATA
    46.
    发明申请
    APPARATUSES, METHODS AND SYSTEMS FOR ESTIMATING WATER DIFFUSIVITY AND MICROCIRCULATION OF BLOOD USING DW-MRI DATA 审中-公开

    公开(公告)号：WO2016075329A3

    公开(公告)日：2016-05-19

    申请号：PCT/EP2015/076678

    申请日：2015-11-16

    Applicant: FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS (FORTH)

    Inventor： MANIKIS, Georgios C ,  KONTOPODIS, Eleftherios ,  MARIAS, Konstantinos

    IPC: G01R33/563 ,  A61B5/055

    Abstract: Apparatuses, methods and systems for estimating water diffusivity and microcirculation of blood using DW-MRI data ("AEW") are disclosed herein. The apparatuses, methods and systems provide a computational framework for choosing and applying the most appropriate model in different regions of a heterogeneous area on a voxel-by-voxel basis. The apparatuses, methods and systems also configure an intravoxel-incoherent-motion (IVIM) model for estimating water diffusivity and microcirculation of blood in the capillary network from DW-MRI low b-value data. In one implementation, the method uses a small number of b-values (at least 3 in the b-value range of 0-300 s/mm 2 , increasing the upper bound of the low b-value range by one b-value in the absence of DW-MRI signal at 300 s/mm 2 and is able to synthetically generate DW-MRI data corresponding at higher b-values using the derived IVIM equation. The method also accounts for estimating non-Gaussian diffusion parameter K app .

    TEMPERATURE-RESPONSIVE CATALYSTS
    47.
    发明申请
    TEMPERATURE-RESPONSIVE CATALYSTS 审中-公开
    温度响应催化剂

    公开(公告)号：WO2014147192A1

    公开(公告)日：2014-09-25

    申请号：PCT/EP2014/055632

    申请日：2014-03-20

    Applicant: EVONIK INDUSTRIES AG ,  FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS ,  WOLF, Dorit ,  BORRMANN, Rüdiger ,  AZAP, Cengiz ,  VAMVAKAKI, Maria ,  PASPARAKIS, George

    Inventor： WOLF, Dorit ,  BORRMANN, Rüdiger ,  AZAP, Cengiz ,  VAMVAKAKI, Maria ,  PASPARAKIS, George

    IPC: B01J31/16 ,  B01J31/24 ,  B01J31/22

    CPC classification number: B01J31/1658 ,  B01J31/2273 ,  B01J31/2404 ,  B01J2231/321 ,  B01J2231/4261 ,  B01J2231/543 ,  B01J2231/645 ,  B01J2531/16 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/847

    Abstract: The present invention relates to a catalyst comprising (a) a polymer, which has a weight-average molecular weight in the range of from 1000 g/mol – 100000 g/mol and which polymer comprises 50 wt-% - 99.9 wt-% of units derived from one or more non-functionalized monomeric units A, 0.1 wt-% - 50 wt-% of units derived from one or more functionalized monomeric units B, 0 wt-% - 30 wt-% of units derived from one or more cross-linking monomeric units C, wherein monomeric units A are selected from (meth)acrylates and monomers co-polymerizable with (meth)acrylates; wherein monomeric units B are selected from (meth)acrylates and monomers co-polymerizable with (meth)acrylates, which contain one or more phosphorous and/or nitrogen containing uncharged electron donors as coordinative groups; and wherein cross-linking monomeric units C are selected from compounds which comprise at least two olefinically unsaturated double bonds co-polymerizable with A and/or B; and (b) a catalytically-active metal compound that is bound to one or more phosphorous and/or nitrogen containing uncharged electron donors of said polymer. Furthermore, the invention relates to corresponding polymers of afore-mentioned catalyst, a process for producing the catalyst and the polymer as well as the use of the catalyst in homogeneous and/or heterogeneous catalysis.

    Abstract translation: 本发明涉及一种催化剂，其包含（a）聚合物，其重均分子量在1000g / mol-100000g / mol范围内，该聚合物包含50wt％-99.9wt％的 衍生自一种或多种非官能化单体单元A的单元，0.1重量％-50重量％的衍生自一个或多个官能化单体单元B的单元，0重量％-30重量％衍生自一个或多个 交联单体单元C，其中单体单元A选自（甲基）丙烯酸酯和与（甲基）丙烯酸酯共聚的单体; 其中单体单元B选自（甲基）丙烯酸酯和与（甲基）丙烯酸酯共聚的单体，其含有一个或多个含磷和/或氮的不带电荷的电子给体作为配位基团; 并且其中交联单体单元C选自包含与A和/或B可共聚的至少两个烯属不饱和双键的化合物; 和（b）催化活性金属化合物，其与所述聚合物的一个或多个含磷和/或氮的不带电的电子给体结合。 此外，本发明涉及上述催化剂的相应聚合物，用于制备催化剂和聚合物的方法以及催化剂在均相和/或多相催化中的用途。

    REMOVAL OF BOUNDARIES IN DIFFUSE MEDIA
    48.
    发明申请
    REMOVAL OF BOUNDARIES IN DIFFUSE MEDIA 审中-公开
    在DIFFUSE媒体中移除边界

    公开(公告)号：WO2007072085A1

    公开(公告)日：2007-06-28

    申请号：PCT/GR2006/000068

    申请日：2006-12-15

    Applicant: FOUNDATION FOR RESEARCH AND TECHNOLOGY-HELLAS ,  JORGE RIPOLL, Lorenzo ,  NTZIACHRISTOS, Vasilios

    Inventor： JORGE RIPOLL, Lorenzo ,  NTZIACHRISTOS, Vasilios

    IPC: G01N21/47 ,  A61B5/00

    CPC classification number: G01N21/4795 ,  G01N2021/1787

    Abstract: This invention in describes a method which effectively removes the contribution of the boundaries, in essence converting finite diffusive volumes into infinite diffusive volumes of the same absorption and scattering properties. The advantages of such an approach are many, since it opens a new revolutionary way of treating measurements in diffusive media. By making use of such an approach the data can be propagated and backpropagated anywhere in spaces and will enable the use of infinite-case Green functions for solving the inverse problem. This transformation will enable to retain the accuracy of complex numerical methods while boosting the implementation simplicity and computational speed required for obtaining 3D images in diffusive media.

    Abstract translation: 本发明描述了一种有效消除边界贡献的方法，其实质上将有限扩散体积转换成具有相同吸收和散射特性的无限扩散体积。 这种方法的优点是许多，因为它打开了一种新的革命性的方法来处理扩散媒体中的测量。 通过使用这种方法，数据可以在空间中的任何地方进行传播和反向传播，并且将能够使用无限大的Green函数来解决逆问题。 这种转换将能够保持复杂数值方法的准确性，同时提高在扩散介质中获取3D图像所需的实现简单性和计算速度。

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