公开(公告)号：DE69726306D1

公开(公告)日：2003-12-24

申请号：DE69726306

申请日：1997-09-24

Applicant: LOMA LINDA UNIVERSITY LOMA LIN

Inventor： SZALAY A ,  WANG GEFU ,  WANG YUBAO

IPC: C12N15/09 ,  C07K14/00 ,  C07K14/435 ,  C07K16/00 ,  C07K16/40 ,  C07K19/00 ,  C12N9/02 ,  C12N15/02 ,  C12P21/04 ,  C12P21/08 ,  C12P21/06 ,  C12N1/20 ,  C07H21/04

Abstract: A fusion gene is provided comprising the cDNA of Renilla luciferase and the cDNA of the "humanized" Aequorea green fluorescent protein. The fusion gene was used to produce a novel protein, the "Renilla-GFP fusion protein," which displayed both the luciferase activity of Renilla luciferase, and the green fluorescence of GFP. The Renilla-GFP fusion gene is useful as a double marker for monitoring gene expression quantitatively in UV light and by enzyme activity.

公开(公告)号：DE69930249D1

公开(公告)日：2006-05-04

申请号：DE69930249

申请日：1999-04-21

Applicant: LOMA LINDA UNIVERSITY LOMA LIN

Inventor： LANGRIDGE H ,  ARAKAWA TAKESHI

IPC: C12N15/00 ,  A01H5/00 ,  A61K48/00 ,  C07K14/28 ,  C07K14/62 ,  C12N9/88 ,  C12N15/36 ,  C12N15/82

公开(公告)号：AU7476498A

公开(公告)日：1998-11-27

申请号：AU7476498

申请日：1998-05-08

Applicant: LOMA LINDA UNIVERSITY AND MEDI

Inventor： DIAMOND DAVID ,  NEHLSEN-CANNARELLA SANDRA ,  FAGOAGA OMAR R ,  SZALAY ALADAR

IPC: A01K67/027 ,  C12N9/10 ,  C12N15/54 ,  C12Q1/68 ,  C12N5/10

Abstract: This invention relates to histo-blood group O alleles of baboon. The major O allele retains identifying sequence characteristics of the baboon A allele. Other alleles, including a B-like allele, are also disclosed herein. The O alleles of baboon are closer in sequence similarity to the baboon A and B alleles than are any of the baboon ABO alleles to the human alleles of the ABO locus. This invention also provides materials and methods for identifying O alleles, and carriers of O alleles, as well as methods for producing baboons and baboon cells, tissues, and organs having a group O phenotype. Group O baboons, cells, tissues, and organs of the invention are useful for xenotransplantation.

公开(公告)号：DE60111524D1

公开(公告)日：2005-07-21

申请号：DE60111524

申请日：2001-04-27

Applicant: LOMA LINDA UNIVERSITY LOMA LIN ,  YEDA LTD

Inventor： BASHKIROV VLADIMIR ,  SCHULTE W ,  SHCHEMELININ SERGI ,  BRESKIN AMOS ,  CHECHIK RACHEL ,  GARTY GUY ,  MILLIGAN JAMIE

IPC: G01N27/64 ,  G01Q60/00 ,  H01J49/40 ,  G01T1/02

公开(公告)号：EP4464257A2

公开(公告)日：2024-11-20

申请号：EP24190390.5

申请日：2019-04-23

Applicant: Loma Linda University

Inventor： BUSSELL, Mark

IPC: A61B8/12

Abstract: The disclosure is related to a system and method for operating a traction device to detect blood flow patterns in a subject for managing neuropathy related conditions through intraneural facilitation (INF). According to an embodiment, the INF system and method rely on the traction device for positioning the subject in one or more positions, and a processing device for processing intervening signals obtained by a probe positioned on the subject. The signals received from the probe may be used to determine a two dimensional (2D) plane blood flow pattern. Detected changes in the measured blood flow may be used to determine if further traction device positions are required to ensure that the intervening signals demonstrate normal blood flow patterns with improvements to the neuropathy condition. The 2D flow pattern may calculate at least one of Volume Flow (VF) and Pulsatility Index (PI) for each set of signals received.

公开(公告)号：EP3760226A1

公开(公告)日：2021-01-06

申请号：EP20170511.8

申请日：2012-09-21

Applicant: Loma Linda University

Inventor： ESCHER, Alan P.

IPC: A61K39/10 ,  C12N9/22 ,  C12N15/70 ,  A61K39/02 ,  A61K49/00 ,  C12N9/50 ,  A61K39/00 ,  C12N9/10 ,  C12N15/117

Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.

公开(公告)号：EP3703730A1

公开(公告)日：2020-09-09

申请号：EP18874580.6

申请日：2018-10-30

Applicant: Loma Linda University

Inventor： ASHWAL, Stephen ,  HOLSHOUSER, Barbara

IPC: A61K38/35 ,  A61K45/06

公开(公告)号：EP2758074B1

公开(公告)日：2020-04-22

申请号：EP12834027.0

申请日：2012-09-21

Applicant: Loma Linda University

Inventor： ESCHER, Alan, P.

IPC: A61K39/10 ,  C12N9/22 ,  C12N15/70 ,  A61K39/02 ,  A61K49/00 ,  C12N9/50 ,  A61K39/00 ,  C12N9/10 ,  C12N15/117

公开(公告)号：EP3351252A1

公开(公告)日：2018-07-25

申请号：EP17201450.8

申请日：2007-09-28

Applicant: LOMA LINDA UNIVERSITY

Inventor： LI, Fengchun ,  ESCHER, Alan P.

IPC: A61K31/7088 ,  A61K39/00 ,  A61K35/12 ,  C12N15/113

CPC classification number: C12N5/0602 ,  A61K31/7088 ,  A61K35/12 ,  A61K39/001 ,  A61K2035/122 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

Abstract: Mammalian host cells for use in a cell-mediated transfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of down-regulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs down-regulates the expression of the target gene in living cells.

公开(公告)号：EP3220846A1

公开(公告)日：2017-09-27

申请号：EP15860535.2

申请日：2015-11-19

Applicant: Faculty Physicians and Surgeons of Loma Linda University School of Medicine

Inventor： BALDWIN, Dalton Duane

IPC: A61B34/00

CPC classification number: A61B17/00 ,  A61B46/10 ,  A61B90/30 ,  A61B2017/00876 ,  A61B2017/00951 ,  A61B2017/00973 ,  A61B2090/309 ,  G05G1/30 ,  H01H3/14 ,  H01H9/04 ,  H01H9/18

Abstract: A system and method of illuminating a surgical foot pedal. The illuminated protective covering can include a plurality of illuminating devices surrounding at least a majority of a length of each of the top and lateral edges of the surgical device. The illuminated protective covering also includes a sheet surrounding the upper surface and the lower surface of the surgical device and the plurality of illuminating devices, the sheet being configured to protect the surgical device from debris during the surgical procedure. A friction portion can be attached to the sheet, the friction portion being positioned on the sheet such that the friction portion is adjacent the bottom surface of the surgical device when the sheet surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.

Abstract translation: 照亮手术脚踏板的系统和方法。 照明的保护性覆盖物可以包括围绕手术装置的顶部和侧向边缘中的每一个的至少大部分长度的多个照明装置。 照明的保护性覆盖物还包括围绕外科手术装置的上表面和下表面以及多个照明装置的薄片，薄片构造成在外科手术过程中保护手术装置免受碎屑影响。 摩擦部分可以被附接到片材，摩擦部分被定位在片材上，使得当片材围绕脚踏板时摩擦部分邻近外科装置的底部表面，摩擦部分被构造成防止 脚踩在地板或其他表面上。