公开(公告)号：WO2014098593A1

公开(公告)日：2014-06-26

申请号：PCT/NL2013050925

申请日：2013-12-19

Applicant: STICHTING TECH WETENSCHAPP ,  STICHTING VU VUMC ,  UNIV GRONINGEN ,  GRONINGEN ACAD ZIEKENHUIS

Inventor： RAAPHORST RENSKE ,  LUURTSEMA GERT ,  WINDHORST ALBERT DIRK ,  LAMMERTSMA ADRIAAN

IPC: A61K51/04 ,  A61K31/277 ,  C07B59/00

CPC classification number: A61K31/277 ,  A61K51/04 ,  C07B59/001

Abstract: The invention is directed to a compound, a salt or a solvate thereof according to (I) wherein R1 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group, R2, R3, R4 and R5 are eacn independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein R1 is a methyl group, and R3 is a R3 is a fluoroalkyl group or a [18F]fluoroalkyl group, R2, R4 and R5 are each independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein if R1 is hydrogen, at least one of R2, R3, R4 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group.

Abstract translation: 本发明涉及根据（I）的化合物，其盐或溶剂合物，其中R 1是任选支链的氟代烷基或[18 F]氟代烷基，R 2，R 3，R 4和R 5独立地是甲基，[3 H] 甲基，氟代烷基或[18 F]氟烷基，R 6为（R） - 氰基或（S） - 氰基; 或其中R 1为甲基，R 3为R 3为氟烷基或[18 F]氟代烷基，R 2，R 4和R 5各自独立地为甲基，[3 H]甲基，氟代烷基或[18 F]氟代烷基，和 R6是（R） - 氰基或（S） - 氰基; 或其中如果R 1是氢，则R 2，R 3，R 4中的至少一个是任选支链的氟代烷基或[18 F]氟代烷基。

公开(公告)号：WO2013151440A3

公开(公告)日：2014-01-09

申请号：PCT/NL2013050256

申请日：2013-04-05

Applicant: STICHTING VU VUMC

Inventor： VAN STRAALEN NICOLAAS MARIA ,  ROELOFS THEODORUS FRANK MARIA

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q2600/142 ,  C12Q2600/158

Abstract: A method for determining toxicity of a sample, particularly a soil sample suspected of containing polycyclic aromatic hydrocarbon pollutants, is provided. The method allows for quantification of toxicity levels based on gene expression profiling of a test organism, for example Folsomia candida,exposed to the sample.

Abstract translation: 提供了一种确定样品毒性的方法，特别是怀疑含有多环芳烃污染物的土壤样品。 该方法允许基于暴露于样品的测试生物（例如，假丝酵母​​菌）的基因表达谱来定量毒性水平。

公开(公告)号：WO2013070079A8

公开(公告)日：2013-10-24

申请号：PCT/NL2012050793

申请日：2012-11-09

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU VUMC

Inventor： REIJERKERK ARIE ,  DE VRIES HELGA EVELINE

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q2600/178

Abstract: The blood-brain barrier (BBB) separates the blood and the central nervous system (CNS). Here it is disclosed that blood-brain barrier function can be increased with particular nucleic acid sequences, in particular in patients suffering from or diagnosed with Multiple Sclerosis. The use of compounds comprising such nucleic acid sequences for increasing blood-brain barrier function is described.

Abstract translation: 血脑屏障（BBB）分离血液和中枢神经系统（CNS）。 这里公开了可以使用特定的核酸序列，特别是患有或诊断为多发性硬化症的患者来增加血脑屏障功能。 描述了包含这种核酸序列的化合物用于增加血脑屏障功能的用途。

公开(公告)号：WO2013070079A3

公开(公告)日：2013-07-11

申请号：PCT/NL2012050793

申请日：2012-11-09

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU VUMC

Inventor： REIJERKERK ARIE ,  DE VRIES HELGA EVELINE

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q2600/178

Abstract: The blood-brain barrier (BBB) separates the blood and the central nervous system (CNS). Here it is disclosed that blood-brain barrier function can be increased with particular nucleic acid sequences, in particular in patients suffering from or diagnosed with Multiple Sclerosis. The use of compounds comprising such nucleic acid sequences for increasing blood-brain barrier function is described.

Abstract translation: 血脑屏障（BBB）分离血液和中枢神经系统（CNS）。 这里公开了可以用特定的核酸序列增加血脑屏障功能，特别是患有或诊断患有多发性硬化症的患者。 描述了包含这种核酸序列的化合物用于增加血脑屏障功能的用途。

公开(公告)号：WO2012161581A1

公开(公告)日：2012-11-29

申请号：PCT/NL2012/050367

申请日：2012-05-24

Applicant: STICHTING VU-VUMC ,  NUIJTS, Roeland Johannus Marie Wilhelm ,  KOELEMEIJ, Jeroen Cornelis Jean

Inventor： NUIJTS, Roeland Johannus Marie Wilhelm ,  KOELEMEIJ, Jeroen Cornelis Jean

IPC: H04J3/06 ,  H04J14/02

CPC classification number: H04L7/0075 ,  H04J3/0682 ,  H04J14/02 ,  H04J14/0272 ,  H04J14/0275

Abstract: Distribution of reference frequency and timing information in a network involves determining latency between a first and second node from time delay between transmission of a reference frequency and timing signal and reception of an optical return timing signal in response. In a network with pairs of first and second optical fibers in optical fiber connections between network nodes, for transmission of optical data signals separately in mutually opposite directions between the network nodes respectively, provisions are made to transmit the reference frequency and timing signal and the resulting optical return signal via the same fiber, one in the same direction as the unidirectional data signal over that fiber and the other upstream. Repeaters between the nodes may be modified to pass such signals upstream and downstream. In an embodiment wherein the network provides for an optical supervisory channel, the optical filters for combining the optical supervisory channel signal with the unidirectional data signal and separating the optical supervisory channel signal from the unidirectional data signal are used to combine and separate the reference frequency and timing signal and to pass the optical return timing signal. For this purpose, further optical filters may be added outside the main optical data channel to combine and separate the reference frequency and timing signal and the optical supervisory channel and to pass the optical return signal back to the filter that separates the optical supervisory channel signal from the data signal.

Abstract translation: 参考频率和定时信息在网络中的分布涉及从响应于参考频率的传输和定时信号之间的时间延迟以及接收光学返回定时信号来确定第一和第二节点之间的等待时间。 在网络节点之间的光纤连接中具有成对的第一和第二光纤的网络中，为了分别在网络节点之间彼此相反的方向上分别传输光数据信号，提供传输参考频率和定时信号，并且由此得到 通过相同光纤的光返回信号，一个在与该光纤上的单向数据信号相同的方向上，另一个在上游。 节点之间的中继器可以被修改以在上游和下游传递这样的信号。 在网络提供光学监控信道的实施例中，用于将光监控信道信号与单向数据信号组合并将光监控信道信号与单向数据信号分离的滤光器用于组合和分离参考频率和 定时信号并通过光学返回定时信号。 为此，可以将另外的光学滤波器添加到主光学数据通道外部，以组合和分离参考频率和定时信号和光学监控通道，并将光学返回信号传回到将光学监控通道信号与 数据信号。

公开(公告)号：WO2012128616A1

公开(公告)日：2012-09-27

申请号：PCT/NL2012/050025

申请日：2012-01-16

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG ,  STICHTING VU-VUMC ,  WÜRDINGER, Thomas ,  NILSSON, Rolf Jonas

Inventor： WÜRDINGER, Thomas ,  NILSSON, Rolf Jonas

IPC: G01N33/48

CPC classification number: C12Q1/6834 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及分析受试者的血液样品中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的无核血细胞中提取核酸 提供无核血细胞提取的核酸组分，和b）分析所述无核血细胞提取的核酸组分是否存在疾病标志物，其中所述疾病标志物是细胞基因中的疾病特异性突变 所述受试者，或者其中所述疾病标志物是所述受试者细胞的基因的疾病特异性表达谱。

公开(公告)号：EP3152151A1

公开(公告)日：2017-04-12

申请号：EP15730062.5

申请日：2015-06-08

Applicant: Stichting VU-VUmc ,  FOM-Nikhef

Inventor： HENNES, Eric ,  BERTOLINI, Alessandro ,  VAN DEN BRAND, Johannes, Franciscus

IPC: B81B3/00 ,  B81B7/00

CPC classification number: B81B3/0078 ,  B81B2201/0235 ,  B81B2201/0285 ,  B81B2203/0163 ,  G01P15/125

Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.

Abstract translation: 描述了包括预加载悬架弹簧的MEMS传感器和用于机械预加载MEMS传感器的悬架弹簧的方法。 MEMS传感器包括MEMS支撑结构; 连接到所述支撑结构的多个悬架弹簧; 以及由所述悬架弹簧柔性地悬挂的证明质量块; 其中所述悬架弹簧中的至少一个机械地预加载有用于减小所述证明物质的固有频率的压缩力。

公开(公告)号：EP2841947A1

公开(公告)日：2015-03-04

申请号：EP13720130.7

申请日：2013-04-26

Applicant: Stichting VU-VUmc

Inventor： BOSCH, Linda Janna Willemien ,  DE WIT, Meike ,  PINTO MORAIS DE CARVALHO, Beatriz ,  FIJNEMAN, Remond Johannes Adriaan ,  MEIJER, Gerrit Albert ,  JIMENEZ, Cornelia Ramona ,  PIERSMA, Sander Rogier ,  PHAM, Viet Thang ,  OUDGENOEG, Gideon

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  G01N33/6848 ,  G01N2500/10 ,  G01N2570/00 ,  G01N2800/7028

Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

Abstract translation: 本发明提供了一种筛选结直肠癌的方法，所述方法包括：从个体中筛选一种或多种选自表1和/或表6中定义的组的生物标志物的生物样品，其中存在或增加表达 一个或多个相对于对照样品的生物标志物指示个体处于患有或正在遭受结肠直肠癌的风险中。 本发明还提供适用于本发明方法的阵列和试剂盒，治疗结肠直肠癌的方法和用于治疗癌症的方法中的治疗剂。

公开(公告)号：BR112013001136B1

公开(公告)日：2020-12-15

申请号：BR112013001136

申请日：2011-07-15

Applicant: STICHTING VU VUMC ,  STICHTING VUMC

Inventor： ROLF JONAS NILSSOM ,  THOMAS WÜRDINGER

IPC: G01N33/48

Abstract: processo de análise de uma amostra de sangue de um sujeito para a presença de um marcador de doença. a presente invenção refere-se a um processo de análise de uma amostra de sangue de um sujeito para a presença de um marcador de doença, o dito processo compreendendo as etapas de a) extração de ácido nucléico de células de sangue anucleadas na dita amostra de sangue para prover uma fração de ácido nucléico extraída com células de sangue anucleadas, e b) análise de dita fração de ácido nucléico de células de sangue anucleadas para a presença de um marcador de doença, onde o dito marcador de doença é uma mutação específica de doença em um gene de uma célula do dito sujeito, ou onde o dito marcador de doença é um perfil de expressão específico de doença de genes de uma células do dito sujeito.

公开(公告)号：NL2013687B1

公开(公告)日：2016-10-04

申请号：NL2013687

申请日：2014-10-27

Applicant: STICHTING VU-VUMC

Inventor： ERNST JAN BOS

IPC: B29C67/00

Abstract: The present invention provides a method of layered object manufacturing using multiple sheet elements each having a predetermined dimension, wherein the sheet elements comprise first interlocking elements configured to interlock with at least a first further sheet element arranged at a first side of the sheet element, and second interlocking elements configured to interlock with at least a second further sheet element arranged at a second side of the sheet element, wherein the second side is opposite the first side. The method comprises stacking the multiple sheet elements on top of each other, wherein the first interlocking elements of a first one of the multiple sheet elements interlock with the second interlocking elements of a second one of the multiple sheet elements arranged at the first side of the first sheet element, and the second interlocking elements interlock with first interlocking elements of a third one of the multiple sheet elements arranged at the second side of the first sheet element. The invention also provides a sheet element, an object manufacturing device, and object constructed with the method.