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41.发明公开Liposome immunoassays for detection of antigens, antibodies and haptens 失效Liposome-Immunoassay zum Nachweis von Antigenen，Antikörpernund Haptenen。
公开(公告)号：EP0518319A2
公开(公告)日：1992-12-16
申请号：EP92109828.1
申请日：1992-06-11
IPC: G01N33/58
CPC classification number: G01N33/586
Abstract: A liposome direct immunoassay of an antibody, antigen, or hapten in a sample comprises addition of the sample to polymer-enmeshed liposomes having a marker occluded within their inner volume, and incubation of the suspension with complement or a cytolytic agent to cause liposome lysis with subsequent release of the marker, that is measured after sedimentation of the suspension under normal gravity. The polymer is preferably cross-linked polyacrylamide. The assay is very rapid and sensitive. The polymer network enmeshing the liposomes enhance their shelf-life and acts as a selective barrier for diffusion of molecules of different molecular weight to the liposome surface.
Abstract translation: 样品中的抗体，抗原或半抗原的脂质体直接免疫测定包括将样品添加到聚合物封闭的脂质体中，所述脂质体具有封闭在其内部体积内的标记物，并将悬浮液与补体或细胞溶解剂孵育以引起脂质体溶解， 随后释放标记物，即在正常重力下悬浮液沉降后测量。 聚合物优选为交联聚丙烯酰胺。 该测定非常快速和敏感。 使脂质体聚合的聚合物网络增强了其保质期，并且作为将不同分子量的分子扩散到脂质体表面的选择性屏障。
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公开(公告)号：EP0206200B1
公开(公告)日：1992-09-23
申请号：EP86108189.1
申请日：1986-06-16
Inventor： Soreq, Hermona
CPC classification number: C12N9/18 , A61K38/00 , G01N33/573
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43.发明公开Transgenic plants overproducing threonine and lysine 失效Überproduktionvon Threonin und Lysin in transgenen Pflanzen。
公开(公告)号：EP0485970A2
公开(公告)日：1992-05-20
申请号：EP91119328.2
申请日：1991-11-13
Inventor： Galili,Gad , Shaul,Orit , Perl,Avihai
CPC classification number: C12N15/8254 , C12N9/12 , C12N9/88 , C12N15/8251 , C12N15/8253 , C12P13/08
Abstract: A chimeric gene construct comprising a DNA sequence encoding an enzyme having aspartate kinase (AK) activity is provided, which is capable of expression in plant cells with subsequent increased production Of threonine. Transgenic plants containing in their cells said chimeric gene overproduce threonine and transgenic plants containing in their cells said chimeric gene and a second chimeric gene comprising a DNA sequence coding for an enzyme having dihydrodipicolinate synthase (DHPS) activity, overproduce both threonine and lysine. The transgenic plants are resistant to lysine and threonine, to derivative: thereof and to selective inhibitors Of the plant enzymes DHFS or AK, and thus these compounds may be used as selective herbicides in locus where the transgenic plants are cultivated.
Abstract translation: 提供了包含编码具有天冬氨酸激酶（AK）活性的酶的DNA序列的嵌合基因构建体，其能够在随后增加的苏氨酸的产生中在植物细胞中表达。 在其细胞中含有转基因植物，所述嵌合基因过量产生苏氨酸和在其细胞中含有所述嵌合基因的转基因植物，以及包含编码具有二氢吡啶二羧酸合成酶（DHPS）活性的酶的DNA序列的第二嵌合基因，其过量产生苏氨酸和赖氨酸。 转基因植物对赖氨酸和苏氨酸，其衍生物和植物酶DHFS或AK的选择性抑制剂具有抗性，因此这些化合物可用作培养转基因植物的基因座中的选择性除草剂。
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44.发明公开
公开(公告)号：EP0485708A2
公开(公告)日：1992-05-20
申请号：EP91115579.4
申请日：1991-09-13
Inventor： Levin, Gideon
CPC classification number: C08J3/245 , A01N25/10 , A61K47/32 , C08F8/34 , C08J5/18 , C08J2327/06 , C08K5/39 , Y02P20/149 , C08L27/06 , C08F114/06
Abstract: Crosslinked plasticized or unplasticized PVC products having gradient crosslinking density, with a high crosslinking density on the outer surface and a low or none crosslinking density at the bulk of the product, are prepared by immersing the PVC product in a hot water solution of a crosslinking material and a phase transfer catalyst. The products obtained provide controlled release of substances occluded within the PVC matrix, thus preventing leakage of plasticizers, stabilizers and other additives, and permitting controlled slow release of substances like pesticides, fertilizers, drugs and the like, into the surrounding environment.
Abstract translation: 通过将PVC产品浸入交联材料的热水溶液中制备具有梯度交联密度，外表面上具有高交联密度和产品主体上低交联密度或低交联密度的交联的增塑或未增塑PVC产品 和相转移催化剂。 获得的产品提供控制在PVC基体内封闭的物质的释放，从而防止增塑剂，稳定剂和其他添加剂的渗漏，并允许将药物，化肥，药物等物质缓慢释放到周围环境中。
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45.发明公开Compounds binding to a heparin receptor as inhibitors of T cell-mediated immune reactions 失效作为T细胞介导的免疫反应的抑制剂的化合物与HEPARIN受体的结合
公开(公告)号：EP0375976A3
公开(公告)日：1991-09-04
申请号：EP89122080.8
申请日：1989-11-30
Inventor： Cohen, Irun R. , Miller, Theodore D. , Naparstek, Yaacov
IPC: A61K31/725 , A61K31/795 , A61K31/00
CPC classification number: A61K31/715 , A61K31/00 , A61K31/795
Abstract: There are provided compositions for the inhibition of T-Cell-mediated immune reactions, which comprise an effective quantity of Fragmin (T.M.) of polyanethol sulfonate, of dextran sulfate or of another compound which binds to the heparin receptor. The compositions of the invention are effective as active ingredient of pharmaceutical compositions for the treatment of patients afflicted with metastatic tumor cells. Another feature of the invention is an assay for the determination of inhibitory effects of such compositions on T-cell immunity in vivo by their ability to compete with heparin for binding in the heparin receptor.
Abstract translation: 提供了用于抑制T细胞介导的免疫反应的组合物，其包含有效量的聚苯醚磺酸盐的Fragmin（T.M），硫酸葡聚糖或与肝素受体结合的另一种化合物。 本发明的组合物作为用于治疗患有转移性肿瘤细胞的患者的药物组合物的活性成分是有效的。 本发明的另一个特征是通过与肝素竞争肝素受体结合的能力来测定这些组合物对体内T细胞免疫的抑制作用的测定。
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Patent Agency Ranking
公开(公告)号：EP0416652A3
公开(公告)日：1991-04-03
申请号：EP90117301.3
申请日：1990-09-07
Inventor： Novick, Daniela , Rubinstein, Menachem
CPC classification number: C07K14/715 , A61K38/00 , Y10S530/834
Abstract: Soluble human IFN-gamma receptor extracellular fragment and salts, functional derivatives, precursors and active fractions thereof are provided in substantially purified form. They are useful as pharmaceutically active substances for protecting against the deleterious effects of IFN-gamma, e.g. in autoimmune diseases.
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公开(公告)号：EP0415321A1
公开(公告)日：1991-03-06
申请号：EP90116388.1
申请日：1990-08-27
Inventor： Schwartz, Michal , Cohen, Avi
CPC classification number: C12N9/1044 , A61K38/00 , C07K14/475 , C07K16/22
Abstract: A novel oligodendrocyte cytotoxic factor, salts, precursors, fragments and homologs thereof and functional derivatives of said factor or of its fragments or homologs, are selectively toxic to the oligodendrocyte lineage. Pharmaceutical compositions comprising them are useful for inducing regeneration of injured nerves of the central nervous system in mammals.
Abstract translation: 一种新的少突胶质细胞细胞毒性因子，其盐，前体，其片段和同系物以及所述因子或其片段或同系物的功能衍生物对少突胶质细胞谱系具有选择性毒性。 包含它们的药物组合物可用于诱导哺乳动物中的中枢神经系统受损神经的再生。
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公开(公告)号：EP0406848A1
公开(公告)日：1991-01-09
申请号：EP90112801.7
申请日：1990-07-04
Inventor： Milstein, David , Ben-David, Yehoshua
CPC classification number: B01J31/2409 , B01J31/24 , B01J31/2414 , B01J2231/34 , B01J2531/824 , C07C45/49 , C07C67/343 , C07C303/22 , C07C69/76 , C07C309/44
Abstract: Aromatic aldehydes are produced by catalytic formylation of aryl chlorides in the presence of a palladium chelating phosphine ligand complex of the formula (R₁R₂P(CH₂) n PR₃R₄)Pd, wherein n is 3 or 4 and R₁ to R₄ are H, alkyl, cycloalkyl or aryl, at least one of them being alkyl or cycloalkyl.
Abstract translation: 在式（R1R2P（CH2）nPR3R4）Pd，其中n为3或4且R1至R4为H的钯螯合膦配体络合物存在下，通过芳基氯化物的催化甲酰化生成芳族醛，R 1至R 4为H，烷基，环烷基或芳基 ，其中至少一个是烷基或环烷基。
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公开(公告)号：EP0377095A2
公开(公告)日：1990-07-11
申请号：EP89120105.5
申请日：1989-10-30
Inventor： Breskin, Amos , Chechik, Rachel
IPC: G01T1/29
CPC classification number: G01T1/2935
Abstract: Apparatus for radiographic imaging including a multistage avalanche chamber (20) receiving radiation from a multiplicity of radiation point sources on a sample (18) and providing a multiple photon output indicative of the path of the emitted radiation through the avalanche chamber, image intensification (23) apparatus receiving the photon output of the avalanche chamber, a camera (24) receiving an output from the image intensification apparatus; image processing apparatus for receiving the camera output and carrying out a vector analysis on the information contained in the camera output in order to determine the location of the radiation emitting point source on the sample.
Abstract translation: 用于放射照相成像的装置，包括多级雪崩室，其接收来自样品上的多个辐射点源的辐射，并提供指示所述发射的辐射通过雪崩室的路径的多光子输出，接收雪崩的光子输出的图像增强装置 接收来自图像增强装置的输出的相机; 图像处理装置，用于接收相机输出并对包含在相机输出中的信息进行矢量分析，以确定辐射发射点源在样本上的位置。
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公开(公告)号：EP0369413A2
公开(公告)日：1990-05-23
申请号：EP89121094.0
申请日：1989-11-14
Inventor： Novick, Daniela , Mory, Yves , Fischer, Dina G. , Revel, Michel , Rubinstein, Menachem
IPC: C12N15/12 , A61K38/17 , C07K14/715 , C12N5/10 , C12N1/11 , C12P21/08 , A61K39/395 , C12N5/20
CPC classification number: C07K14/7156 , A61K38/00 , C07K14/715 , C07K16/2866
Abstract: A DNA molecule comprising a recombinant DNA molecule or a cDNA molecule comprising the following nucleotide sequence, a protein wherein at least part of the protein molecule is encoded by the following nucleotide sequence or a pharmaceutical composition comprising said protein. The protein is used for protecting against the deteterious effects of IFN-gamma in mammals.
Abstract translation: 包含重组DNA分子或包含以下核苷酸序列的cDNA分子的DNA分子，其中至少部分蛋白质分子由以下核苷酸序列编码的蛋白质或包含所述蛋白质的药物组合物。 该蛋白质用于防止哺乳动物中IFN-γ的有害作用。
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