公开(公告)号：KR1020130033624A

公开(公告)日：2013-04-04

申请号：KR1020110097386

申请日：2011-09-27

Applicant: 대구한의대학교산학협력단

Inventor： 박문기 ,  이종록 ,  정대화 ,  이양수

IPC: A61K36/27 ,  A61K36/605 ,  A61K36/234 ,  A61K36/804 ,  A61K8/97 ,  A61Q7/00

CPC classification number: A61K36/27 ,  A61K8/97 ,  A61K36/234 ,  A61K36/605 ,  A61K36/804 ,  A61K2800/74 ,  A61Q7/00

Abstract: PURPOSE: An external use composition containing a complex crude drug extract which prevents alopecia and promotes hair growth is provided to suppress dandruff without causing side effects or toxicity. CONSTITUTION: An external use composition which prevents alopecia and promotes hair growth contains a complex crude drug extract as an active ingredient. The complex crude drug extract includes Morus alba leaves, mulberry, Pleuropterus multflorus, Ligusticum wallichiii Franch, Chrysanthemum lavandulifolum, and Rehmannia glutinosa var. purpurea. The extract is prepared using water including purified water, alcohol, C1-C4 alcohol, or a mixture thereof. [Reference numerals] (AA) Control group; (BB) 6-th group;

Abstract translation: 目的：提供含有防止脱发并促进头发生长的复合生药提取物的外用组合物，以抑制头皮屑而不引起副作用或毒性。 构成：防止脱发并促进毛发生长的外用组合物含有复合生药提取物作为活性成分。 复合生物药物提取物包括桑ba，桑，，茯苓，枸杞，菊苣和地黄。 菊。 提取物使用包括纯化水，醇，C 1 -C 4醇或其混合物的水制备。 （附图标记）（AA）对照组; （BB）第6组;

公开(公告)号：KR101059282B1

公开(公告)日：2011-08-24

申请号：KR1020090000631

申请日：2009-01-06

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  김광중 ,  장은영 ,  최형준 ,  김상찬 ,  이종록

IPC: A61K36/35 ,  A61P25/30

Abstract: 본 발명은 금은화추출물을 유효성분으로 함유하는 조성물에 관한 것으로서, 구체적으로 본 발명의 금은화 추출물은 약물 중독의 지표로 사용되는 보행성 활동량(locomotor activity)의 감소효과뿐만 아니라, 뇌의 측핵과 선조체에서의 신경활성 지표인 c-Fos 발현을 급격히 감소시킴을 확인함으로써, 상기 조성물은 약물 중독 및 금단증상의 예방 및 치료를 위한 약학조성물 또는 건강기능식품으로 유용하게 이용될 수 있다.
금은화, 보행성 활동량, c-Fos, 코카인, 금단증상

Abstract translation: 本发明涉及含有金银花提取物作为有效成分的组合物，具体地，本发明以及走行活动的减少金银花提取物用作药物成瘾（运动活性）的指标，在​​核上的侧部和大脑的纹状体 由神经活动的指标，c-fos表达证实锡金迅速下降，该组合物可以作为药物成瘾，以及药物组合物或膳食补充剂的戒断症状的预防和治疗是有用的。

公开(公告)号：KR1020100081404A

公开(公告)日：2010-07-15

申请号：KR1020090000631

申请日：2009-01-06

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  김광중 ,  장은영 ,  최형준 ,  김상찬 ,  이종록

IPC: A61K36/35 ,  A61P25/30

Abstract: PURPOSE: A composition containing Lonicera japonica Thunberg extract is provided to reduce c-Fos expression and to prevent and treat drug addiction and withdrawal symptom. CONSTITUTION: A pharmaceutical composition for preventing and treating drug addiction and withdrawal symptom contains 0.02-50 weight% of Lonicera japonica Thunberg extract as an active ingredient. The extract is a soluble extract using water, low alcohol solvent of C1-C4, or mixture solvent thereof. The drug is cocaine, amphetamine, morphine, nicotine, or caffeine. A health food for preventing and treating drug addiction and withdrawal symptom contains Lonicera japonica Thunberg extract as an active ingredient.

Abstract translation: 目的：提供含有金银花Thonberg提取物的组合物，以减少c-Fos表达，并预防和治疗药物成瘾和戒断症状。 构成：用于预防和治疗药物成瘾和戒断症状的药物组合物含有0.02-50重量％的金银花Thunberg提取物作为活性成分。 提取物是使用水，C1-C4的低级醇溶剂或其混合溶剂的可溶性提取物。 该药物是可卡因，苯丙胺，吗啡，尼古丁或咖啡因。 用于预防和治疗药物成瘾和戒断症状的保健食品含有金银花忍冬提取物作为活性成分。

公开(公告)号：KR1020090072848A

公开(公告)日：2009-07-02

申请号：KR1020070141081

申请日：2007-12-29

Applicant: 대구한의대학교산학협력단

Inventor： 김상찬 ,  박숙자 ,  이종록

IPC: A61K36/48 ,  A61P1/02

CPC classification number: A61K36/48 ,  A61K36/489 ,  A61K2236/331 ,  A61K2236/333 ,  A61Q11/00 ,  Y10S514/901

Abstract: A composition for preventing and treating dental caries is provided to have excellent antibacterial effect to Streptococcus mutans. A composition for preventing and treating dental caries comprises a Sophorae radix extract as an active ingredient. The extract is isolated using water, C1-C4 low alcohol or their mixture solvent. The composition comprises 0.01-50 weight% of the extract based on the total weight. The composition is used in a form of tooth paste, spray for oral cavity or tissue for oral cavity. A health food for preventing and improving dental caries comprises a Sophorae radix extract comprises as an active ingredient. The health food is used in a form of powder, granule, tablet, capsule or beverage.

Abstract translation: 提供了用于预防和治疗龋齿的组合物以对变形链球菌具有优异的抗菌作用。 用于预防和治疗龋齿的组合物包括作为活性成分的苦参提取物。 使用水，C1-C4低级醇或其混合溶剂分离提取物。 该组合物包含基于总重量的0.01-50重量％的提取物。 组合物以牙膏的形式使用，用于口腔喷雾或用于口腔的组织。 用于预防和改善龋齿的保健食品包括作为活性成分的苦参提取物。 保健食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。

公开(公告)号：KR1020090055261A

公开(公告)日：2009-06-02

申请号：KR1020070122095

申请日：2007-11-28

Applicant: 대구한의대학교산학협력단

Inventor： 김상찬 ,  박숙자 ,  이종록 ,  양재하 ,  조미정 ,  최송이 ,  조용걸

IPC: A61K36/48 ,  A61P17/10 ,  A61K8/97

Abstract: A composition for improving and treating acne vulgaris is provided to have antibacterial effect against P. acnes using a Caesalpinia sappan L. extract. A composition of skin external preperation for improving and treating acne vulgaris comprises 0.1-50 weight% of Caesalpinia sappan L. extract as an active ingredient. The extract is isolated using water, ethanol, methanol, propanol, butanol, acetone, ethylacetate, hexane, butylenes glycol, propylene glycol, hydrous butylenes glycol, hydrous propylene glycol and hydrous glycerin. The composition is used in a form of cream, gel, patch, ointment, plaster, lotion, liniment, or cataplasma agent. The composition is also used in a form of skin, lotion, nutrition lotion, nutrition cream, massage cream, essence, or pack.

Abstract translation: 提供用于改善和治疗寻常痤疮的组合物，以使用Caesalpinia sappan L.提取物对痤疮丙酸杆菌具有抗菌作用。 用于改善和治疗寻常痤疮的皮肤外用组合物包含0.1-50重量％的Caesalpinia sappan L.提取物作为活性成分。 使用水，乙醇，甲醇，丙醇，丁醇，丙酮，乙酸乙酯，己烷，丁二醇，丙二醇，水合丁二醇，含水丙二醇和含水甘油分离提取物。 该组合物以乳膏，凝胶，贴剂，软膏，石膏，洗剂，搽剂或粘膜剂的形式使用。 该组合物还以皮肤，洗剂，营养洗剂，营养霜，按摩膏，精华液或包装的形式使用。

公开(公告)号：KR100881369B1

公开(公告)日：2009-02-02

申请号：KR1020070085247

申请日：2007-08-24

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  김상찬 ,  이종록 ,  장은영 ,  황미열 ,  김상건

IPC: A61K31/12 ,  A61K31/05 ,  A61P25/30

Abstract: A pharmaceutical composition and a health food for treating and preventing cocainism symptom and withdrawal are provided to reduce drastically locomotor activity used as index of drug-poisoning and the c-Fos expression which is specific characterizing compound. A pharmaceutical composition for treating and preventing cocainism symptom and withdrawal comprises an isoliquiritigenin separated from glycyrrhizae radix of 0.02 to 50% weight as an active ingredient based on total weight of the composition. A health food for treating and preventing cocainism symptom and withdrawal comprises an isoliquiritigenin separated from glycyrrhizae radix as an active ingredient. The health food is refinement, capsule, pilule or liquor.

Abstract translation: 提供了一种用于治疗和预防cocainism症状和戒断的药物组合物和保健食品，以减少用作药物中毒指数的运动活动和作为特异性表征化合物的c-Fos表达。 用于治疗和预防cocainism症状和戒断的药物组合物包含基于组合物总重量作为活性成分从0.02至50重量％的甘草根分离的异喹蕊苷。 用于治疗和预防同时伴有遗传症状和戒断症的保健食品包括与甘草根作为活性成分分离的异iqu草素。 保健食品是精制，胶囊，真菌或酒。

公开(公告)号：KR100815868B1

公开(公告)日：2008-03-21

申请号：KR1020060110698

申请日：2006-11-09

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  김상찬 ,  이종록 ,  장은영 ,  김상건

IPC: A61K36/484 ,  A61P39/00

CPC classification number: A61K36/484 ,  A23V2200/334 ,  A61K2236/331 ,  A61K2236/333 ,  Y10S514/812

Abstract: An extract of Glycyrrhiza radix or liquiritin or liquiritigenin isolated therefrom is provided to show excellent inhibitory effect on release of nucleus accumbens dopamine, thereby being used as a pharmaceutical composition and a health functional food for preventing and treating drug abuse and withdrawal symptoms. A pharmaceutical composition for preventing and treating drug abuse and withdrawal symptoms comprises 0.02-50 wt.% of an extract of Glycyrrhiza radix or liquiritin or liquiritigenin isolated therefrom as an effective ingredient, wherein the extract is prepared by using a solvent selected from the group consisting of water, C1-4 alcohol and a mixture thereof.

Abstract translation: 提供甘草或甘草苷或甘草素的提取物，以显示对伏隔核多巴胺释放的优异抑制作用，从而用作药物组合物和用于预防和治疗药物滥用和戒断症状的保健功能食品。 用于预防和治疗药物滥用和戒断症状的药物组合物包含0.02-50重量％的作为有效成分从其中分离出的甘草或甘草苷或甘草素的提取物，其中所述提取物通过使用选自以下的溶剂来制备： 的水，C 1-4醇及其混合物。

公开(公告)号：KR100686362B1

公开(公告)日：2007-02-22

申请号：KR1020050097980

申请日：2005-10-18

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  김상찬 ,  변성희 ,  서정철 ,  이종록

IPC: A61K36/725 ,  A61P3/04

Abstract: A composition for treating and preventing obesity comprising the extract of Zizyphus jujuba Mill. var. inermis Rehder is provided to inhibit body weight increase, reduce neutral lipid concentration and cholesterol concentration, and increase high density cholesterol concentration. The composition for treating and preventing obesity comprises the extract of Zizyphus jujuba Mill. var. inermis Rehder as an effective ingredient, wherein the Zizyphus jujuba Mill. var. inermis Rehder extract is prepared with a solvent selected from water, ethanol and methanol; the amount of the Zizyphus jujuba Mill. var. inermis Rehder extract is 0.1-50 wt.%; the daily dosage of Zizyphus jujuba Mill. var. inermis Rehder extract is 0.0001 to 100 mg/kg; and the composition is a health food composition.

Abstract translation: 一种治疗和预防肥胖症的组合物，其包含枣汁提取物。 变种。 inermis Rehder用于抑制体重增加，降低中性脂质浓度和胆固醇浓度，并增加高密度胆固醇浓度。 用于治疗和预防肥胖的组合物包含Zizyphus jujuba Mill的提取物。 变种。 inermis Rehder作为一种有效的成分，其中Zizyphus jujuba磨房。 变种。 无水萃取物用选自水，乙醇和甲醇的溶剂制备; Zizyphus jujuba Mill的数量。 变种。 无机提取物为0.1-50重量％; Zizyphus jujuba Mill的日剂量。 变种。 inermis Rehder提取物为0.0001至100 mg / kg; 该组合物是一种健康食品组合物。

公开(公告)号：KR100571853B1

公开(公告)日：2006-04-17

申请号：KR1020050068585

申请日：2005-07-27

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  권영규 ,  김광중 ,  김상찬 ,  김미려 ,  이종록 ,  서정철 ,  장은영 ,  구병수

IPC: A61K36/232 ,  A61P25/22

Abstract: 본 발명은 당귀(
Angelica gigas NAKAI)로부터 추출 분리되는 저급알콜용매 가용 추출물을 포함하는 니코틴 중독 및 금단증상의 예방 및 치료효과를 갖는 조성물에 관한 것으로, 본 발명의 조성물은 니코틴 만성 투여로 인한 약물강화와 의존성에 대한 행동적 민감화의 보행성 활동량을 감소시키고, 뇌의 측핵(nucleus accumbens shell)에서 도파민(dopamine)의 유리를 억제시키는 바, 니코틴 중독 및 금단증상의 치료용 약제 및 건강기능식품에 유용하게 이용될 수 있다.
당귀, 저급알콜, 추출물, 니코틴, 금단증상

Abstract translation: 本发明涉及