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公开(公告)号：KR100977407B1
公开(公告)日：2010-08-24
申请号：KR1020080017089
申请日：2008-02-26
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본 발명은 동물용 면역증강제, 백신보좌제 첨가물 및 보조치료제에 관한 것으로, 보다 상세하게는 동물의 주요 탐식세포인 호중구의 각종 활성을 증강시키고 병원성세균의 공격접종에 대한 비특이적인 방어능을 증진시키는 자이고사카로마이세스 바일리(
Zygosaccharomyces
bailii ) 용균추출물을 함유하는 동물용 면역증강제, 백신보좌제 첨가물, 보조치료제 및 사료첨가제에 관한 것이다.
자이고사카로마이세스 바일리(Zygosaccharomyces bailii), 용균추출물, 호중구, 유주능, 과산화물, 포도상구균, 파스튜렐라균-
公开(公告)号：KR1020090093293A
公开(公告)日：2009-09-02
申请号：KR1020080018739
申请日：2008-02-29
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A61K36/06
Abstract: A bacteriolysis extract of Saccharomyces dairenensis is provided to enhance non-specific immunity to pathogenic bacteria and activation of neutrophil and use for improving vaccine efficiency and immune enhancer. An immune enhancer, vaccine adjuvant, adjuvant treating agent or feed additive comprises the bacteriolysis extract of Saccharomyces dairenensis as an active ingredient. A method for producing the bacteriolysis extract of Saccharomyces dairenensis comprises: a step of culturing the Saccharomyces dairenensis in culture media at 26°C for 72 hours; a step of suspending the culture material in PBS buffer after centrifuging; a step of adding and treating dissolution buffer for two or three days; and a step of adjusting pH concentration to 6.5-7.2 and storing in a refrigerator.
Abstract translation: 提供了Saccharomyces dairenensis的溶菌提取物，以增强对病原菌的非特异性免疫和嗜中性粒细胞的活化，并用于提高疫苗效率和免疫增强剂。 免疫增强剂，疫苗佐剂，佐剂处理剂或饲料添加剂包括作为活性成分的Saccharomyces dairenensis的溶菌提取物。 一种酿酒酵母溶菌提取物的制备方法，包括：将培养基中的酵母在26℃下培养72小时的步骤; 离心后将培养物悬浮于PBS缓冲液中的步骤; 添加和处理溶解缓冲液两三天的步骤; 以及将pH浓度调节至6.5-7.2并储存在冰箱中的步骤。
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Patent Agency Ranking
公开(公告)号：KR100884086B1
公开(公告)日：2009-02-18
申请号：KR1020070040731
申请日：2007-04-26
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본 발명은 본제 1kg내에 황련추출물 500g(50 중량%); 연교추출물 100g(10 중량%); dextrose 300g(30 중량%); 감초추출물 100g(10 중량%를 포함하여 구성된 것을 특징으로 하는 황련 및 연교추출물을 이용한 사료첨가제 및 그 추출방법을 제공한다.
상기와 같은 본 발명은 연교 및 황련으로부터 얻어지는 추출물을 일정량을 사료에 첨가하여 가축들에게 급여하므로써, 가축의 일당증체량 및 사료효율 개선를 통한 성장촉진과 면역세포(림파구)의 증식을 통하여 면역증강 및 이물질이 가지는 병원균에 대한 항균특성을 이용하여 질병예방효과가 발현되도록 연교 및 황련을 첨가한 사료첨가제를 제공하므로 그에 따라 항생제가 들어있는 사료첨가제의 대용으로 활용되는 장점을 가지고 있다.
황련추출물, 연교추출물, 사료첨가제, 추출물-
公开(公告)号：KR1020080114231A
公开(公告)日：2008-12-31
申请号：KR1020070063592
申请日：2007-06-27
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/758 , A61P37/02
CPC classification number: A61K36/758 , A23V2200/324 , A61K9/0019 , A61K9/14 , A61K2236/331 , A61K2236/39 , A61K2236/51 , Y10S514/885
Abstract: A method for manufacturing an immune enhancing composition using Zanthoxylli Fructus crust Fizeau polysaccharide extracts as an active ingredient is provided to have a superior immunostimulating activity, to enhance an immunogenicity of animal and to be used as an immunoadjuvant for animal, a vaccine throne and an adjuvant treating agent. A method for manufacturing an immune enhancing composition using Zanthoxylli Fructus crust Fizeau polysaccharide extracts as an active ingredient comprises steps of: obtaining crude extracts by heating Zanthoxylli Fructus crust; concentrating the extracts; and obtaining the polysaccharide fraction by filtering the condensed products.
Abstract translation: 本发明提供使用花椒壳多糖提取物作为活性成分的免疫增强组合物的制造方法，具有优异的免疫刺激活性，增强动物的免疫原性，并用作动物免疫佐剂，疫苗王位和佐剂 处理剂。 使用花椒壳多糖提取物作为活性成分制造免疫增强组合物的方法包括以下步骤：通过加热花椒油酯来获得粗提物; 浓缩提取物; 并通过过滤冷凝产物获得多糖级分。
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公开(公告)号：KR1020080093486A
公开(公告)日：2008-10-22
申请号：KR1020070037225
申请日：2007-04-17
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/752 , A61P37/00
CPC classification number: A61K36/752 , A23V2200/324 , A61K2236/331 , Y10S514/885
Abstract: An extract of Citrus unshiu Markovich is provided to enhance various activities of granulocyte and macrophage and induce strong defence capability on attach inoculation of pathogenic bacteria, thereby being used as an animal medicine such as an animal immuno-enhancing agent and a vaccine adjuvant and a feed additive for treating and preventing animal diseases efficiently. A method for purifying an extract of Citrus unshiu Markovich comprises the steps of: (a) extracting the Citrus unshiu Markovich with hot water at a temperature of 80-120 deg.C for 2-3 hours to obtain a crude extract; (b) concentrating the crude extract; and (c) filtering the concentrate to obtain a polysaccharide fraction by filtering paper and microorganism filtering. A composition for increasing immunity comprises the extract of Citrus unshiu Markovich as an active ingredient. The composition further comprises a pharmaceutically acceptable carrier or an excipient.
Abstract translation: 提供柑橘提取物马可夫提取物，以增强粒细胞和巨噬细胞的各种活性，并在附着接种病原菌时诱发强大的防御能力，从而被用作动物药物如动物免疫增强剂和疫苗佐剂和饲料 用于有效治疗和预防动物疾病的添加剂。 一种纯化马铃薯柑橘提取物的方法，包括以下步骤：（a）用80-120℃的热水提取马铃薯柑橘2-3小时，得到粗提物; （b）浓缩粗提物; 和（c）过滤浓缩物以通过滤纸和微生物过滤获得多糖级分。 用于增加免疫力的组合物包含作为活性成分的马铃薯柑橘提取物。 组合物还包含药学上可接受的载体或赋形剂。
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公开(公告)号：KR1020080092008A
公开(公告)日：2008-10-15
申请号：KR1020070035258
申请日：2007-04-10
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: An extract of Lithospermum erythrorhizon is provided to enhance various activities of neutrophil or macrophages and induce strong protectivity on attack inoculation of pathogenic bacteria, thereby being utilized as an immune enhancing agent, a vaccine adjuvant, an adjuvant therapeutic agent and a feed additive for an animal. An extract of Lithospermum erythrorhizon increases the activity of immunocyte such as neutrophil or macrophages. A method for preparing the extract of Lithospermum erythrorhizon comprises the steps of: (a) boiling dried Lithospermum erythrorhizon with distilled water to obtain the extract of Lithospermum erythrorhizon; (b) filtering the extract; and (c) hydrolyzing a filtrate.
Abstract translation: 提供紫草提取物以增强嗜中性粒细胞或巨噬细胞的各种活性，并在致病细菌的侵袭接种中诱发强的保护作用，从而用作免疫增强剂，疫苗佐剂，佐剂治疗剂和动物饲料添加剂 。 紫苏提取物增加免疫细胞如嗜中性粒细胞或巨噬细胞的活性。 制备红豆杉提取物的方法包括以下步骤：（a）用蒸馏水煮沸干燥的紫草红，得到红豆杉提取物; （b）过滤提取物; 和（c）水解滤液。
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公开(公告)号：KR1020080081500A
公开(公告)日：2008-09-10
申请号：KR1020070021571
申请日：2007-03-05
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A61K36/064 , C12N1/16
Abstract: An exo-polysaccharide extracted from a Candida spp., strain through a physicochemical method is provided to show the immunity enhancing effect on various immunocytes such as neutrophil, macrophage and lymphocyte, thereby being widely applied to a vaccine, an animal immunity-enhancing agent, and an adjuvant therapeutic agent. An animal immunity enhancing agent comprises exo-polysaccharides extracted from a culture material of a Candida spp., strain such as Candida albicans and Candida tropicalis. A method for preparing the exo-polysaccharides derived from the Saccharomyces spp. strain comprises the steps of: (a) after suspending pure colonies obtained by culturing the Candida spp., strain in sterile saline solution, inoculating 1 ml of the suspension into 1,000 ml of yeast malt broth and culturing it at a temperature of 28 deg.C for 72 hours; (b) after adding two times amount of distilled water into a culture material obtained from the step(a) and mixing it, boiling the mixture at a temperature of 100 deg.C for 1 hour and centrifuging the boiled mixture under 3,000xg for 30 minutes to collect supernatant therefrom; and (c) after adding two times amount of ethyl alcohol to the supernatant and mixing it, leaving a mixture in a cool chamber at a temperature of 4 deg.C for 2 days and collecting precipitated polysaccharides therefrom.
Abstract translation: 提供通过物理化学方法从假丝酵母属菌提取的外多糖，以显示对嗜中性粒细胞，巨噬细胞和淋巴细胞等各种免疫细胞的免疫增强作用，从而广泛应用于疫苗，动物免疫增强剂， 和辅助治疗剂。 动物免疫增强剂包括从假丝酵母属的培养物提取的外多糖，白色念珠菌和热带假丝酵母等菌株。 一种制备衍生自酵母属（Saccharomyces spp）的外多糖的方法。 菌株包括以下步骤：（a）在通过在无菌盐水溶液中培养假丝酵母属菌株获得的纯菌落后，将1ml悬浮液接种到1,000ml酵母麦芽肉汤中，并在28℃的温度下培养。 C 72小时; （b）在从步骤（a）获得的培养物中加入两倍量的蒸馏水并混合后，在100℃的温度下将混合物煮沸1小时，并将煮沸的混合物在3000xg下离心30分钟 分钟收集上清液; 和（c）在向上清液中加入两倍量的乙醇并混合后，在4℃的温度下在冷室中留下混合物2天，并从中收集沉淀的多糖。
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