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公开(公告)号：KR1019880012556A
公开(公告)日：1988-11-28
申请号：KR1019870003977
申请日：1987-04-24
Applicant: 한국과학기술연구원
IPC: C07D215/22
Abstract: 내용 없음
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公开(公告)号：KR100345465B1
公开(公告)日：2002-07-26
申请号：KR1020000038284
申请日：2000-07-05
Applicant: 한국과학기술연구원
IPC: C07D477/10
Abstract: 본 발명은 항균제로 유용한 신규의 1-베타메틸카바페넴 유도체, 그를 포함하는 약학적 조성물 및 그의 제조방법에 관한 것으로서, 구체적으로 화학식 1로 표시되는 카바페넴 모핵의 2번 위치에 주요 관능기로서 5-(2'-이소옥사졸릴에텐닐)피롤리딘-3-티오기 또는 5-(2'-이소티아졸릴에텐닐)피롤리딘-3-티오기가 치환된 1-베타메틸카바페넴 유도체, 그를 포함하는 약학적 조성물 및 그의 제조방법에 관한 것이며, 본 발명에 의한 1-베타메틸카바페넴 유도체는 디하이드로펩티다제-I에 대해 안정하고 그람양성균 및 그람음성균 모두에 대해 우수한 항균 활성을 보이는 유용한 항균제이다.
상기 화학식 1에서, R은 명세서에 기재된 바와 같다.-
Patent Agency Ranking
公开(公告)号：KR1020020005334A
公开(公告)日：2002-01-17
申请号：KR1020000039375
申请日：2000-07-10
Applicant: 한국과학기술연구원
IPC: C07D477/10
Abstract: PURPOSE: Provided is a novel 1-β- methylcarbapenem derivative which has an antibacterial effect on both gram negative and positive bacteria and stability to dihydropeptidase-I, and is thus useful as antibacterial agent. And a pharmaceutical composition containing it and its manufacturing method are also provided. CONSTITUTION: The novel 1-β- methylcarbapenem derivative is represented by the formula(I), wherein R is described as in the description, X is ethoxycarbonyl group or hydroxymethyl group; Y is hydroxymethyl group or ethoxycarbonyl group; and Z is methyl group or carbamoylmethyl group. Its manufacturing method comprises the steps of: reacting enolphosphate with thiol derivative in the presence of base, in appropriate solvent to prepare protected carbapenem derivative; and deprotecting the protected carbapenem derivative to obtain 1-β- methylcarbapenem derivative.
Abstract translation: 目的：提供一种新型的1-β-甲基碳青霉烯衍生物，对革兰阴性和阳性细菌具有抗菌作用，对二氢肽酶-I具有稳定性，因此可用作抗菌剂。 还提供含有它的药物组合物及其制备方法。 构成：新颖的1-β-甲基碳青霉烯衍生物由式（I）表示，其中R如描述中所述，X是乙氧基羰基或羟甲基; Y是羟甲基或乙氧基羰基; Z为甲基或氨基甲酰基甲基。 其制造方法包括以下步骤：在碱的存在下，在合适的溶剂中使烯醇化磷酸酯与硫醇衍生物反应，制备保护的碳青霉烯衍生物; 并将保护的碳青霉烯衍生物脱保护得到1-β-甲基碳青霉烯衍生物。
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公开(公告)号：KR100125130B1
公开(公告)日：1997-12-05
申请号：KR1019940020300
申请日：1994-08-17
Applicant: 한국과학기술연구원
IPC: C07D413/02 , A01N43/26 , C07D263/22
CPC classification number: C07D413/04 , A01N43/76 , C07D263/42
Abstract: The oxazolinon type derivative represented by the following general formula(I) and its preparing method is disclosed with uses as herbicides wherein, R is low alkyl or halogen, low alkyl or trifluoromethyl containing phenyl, X is the same or different, halogen, carbomethoxy, nitro, or halogen, trifluoro substituted phenoxy, A is nitrogen, carbon, n is an integer of 1-3. The oxazolinon type derivative is prepared by a condensation reaction of M-amino acid of the general formula(II) and an acid chloride of the general formula(III) to produce an amino substituted M-amino acid of the general formula(IV), and then dehydration reaction after subjecting to reacting with anhydride nitric acid. The herbicide according to this invention has excellent herbicidal effectiveness in treatment of pre- or postemergency against a dicotyledonous plant.
Abstract translation: 公开了以下通式（I）表示的恶唑啉型衍生物及其制备方法，其用作除草剂，其中R为低级烷基或卤素，低级烷基或含三氟甲基的苯基，X为相同或不同的卤素，甲酯基， 硝基或卤素，三氟取代的苯氧基，A是氮，碳，n是1-3的整数。 恶唑啉型衍生物通过通式（II）的M-氨基酸与通式（III）的酰氯的缩合反应制备，得到通式（IV）的氨基取代的M-氨基酸， 然后与酸酐硝酸反应后进行脱水反应。 根据本发明的除草剂在对双子叶植物的芽前或芽后处理方面具有优异的除草效果。
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公开(公告)号：KR1019970001482B1
公开(公告)日：1997-02-06
申请号：KR1019930024426
申请日：1993-11-17
Applicant: 한국과학기술연구원
IPC: C07D251/28
Abstract: 2,4,6-trifluoro-1,3,5-triazine of structural formula(I) is prepared by reacting 2,4,6-trichloro-1,3,5-triazine with alkali fluorine(potassium fluorine or sodium fluorine) under phase-transition catalyst in a polar solvent. The produced 2,4,6-trifluoro-1,3,5-triazine is used as an intermediate of reactive dyes and is prepared as high yield rate.
Abstract translation: 通过使2,4,6-三氯-1,3,5-三嗪与碱性氟（氟或氟氟酸钠）反应制备结构式（I）的2,4,6-三氟-1,3,5-三嗪， 在相转移催化剂的极性溶剂中。 所制备的2,4,6-三氟-1,3,5-三嗪用作活性染料的中间体，并以高产率制备。
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公开(公告)号：KR1019960014048B1
公开(公告)日：1996-10-11
申请号：KR1019930022655
申请日：1993-10-28
Applicant: 한국과학기술연구원
IPC: C09B62/245
Abstract: The dye composite(I) is made by preparing the azo compound with formula(V) by diazo coupling reaction of the amino compounds(II) and (IV); dissolving 5-chloro-2,4,6-trifluoropyrimidine in a solvent and doping its solution into the azo compound to be pH5-9. The solvent comprises acetonitrile, dioxane or acetone, and pH is controlled by lithium hydroxide.
Abstract translation: 染料复合物（I）通过氨基化合物（II）和（IV）的重氮偶联反应制备式（V）的偶氮化合物来制备; 将5-氯-2,4,6-三氟嘧啶溶解在溶剂中并将其溶液掺杂到偶氮化合物中至pH5-9。 溶剂包括乙腈，二恶烷或丙酮，pH由氢氧化锂控制。
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