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42.发明公开
公开(公告)号：KR1020010015512A
公开(公告)日：2001-02-26
申请号：KR1020000063394
申请日：2000-10-27
Applicant: 한국과학기술연구원
IPC: A61K36/725 , A61K36/752 , A61P3/06 , A61P9/12
Abstract: PURPOSE: A composition containing the extract of jujube and the extract of citrus rind is provided for improving lipid metabolism and lowering blood pressure, so that it can prevent liver diseases, hypertension, arteriosclerosis, hyperlipemia and cancer. CONSTITUTION: The composition contains 0.1 to 5g/weight kg/day of the extract of jujube and 0.1 to 10g/weight kg/day of the extract of citrus rind in a weight ratio of 1:1 to 100:1, in which the extract of jujube is produced by adding 2 to 5 liter of 70 to 95% ethanol into 1 kg of jujube, and extracting them at 50 to 60deg.C for 1 to 24 hours, or by adding 2 to 5 liter of water into 1 kg of citrus rind, and extracting them at 70 to 121deg.C for 30 minutes to 12 hours; the extract of citrus rind is produced by drying citrus rind, adding 3 to 30 liter of 20 to 95% ethanol into 1kg of dried rind, extracting them at 25 to 80deg.C for 1 to 12 hours, filtering the extract, and condensing it under reduced pressure, wherein citrus includes orange, lemon, tangerine, grapefruit or citron.
Abstract translation: 目的：提供含有枣提取物和柑橘皮提取物的组合物，用于改善脂质代谢和降低血压，从而可以预防肝脏疾病，高血压，动脉硬化，高脂血症和癌症。 构成：组合物以1：1〜100：1的重量比含有0.1〜5g / kg的枣提取物和0.1〜10g / kg的柑橘皮提取物，其中提取物 通过向1kg的枣中加入2〜5升的70〜95％的乙醇，在50〜60℃下提取1〜24小时，或者将2〜5升的水加入1kg的 柑橘皮，70〜121℃，30分钟〜12小时提取; 柑橘皮提取物是通过干燥柑橘皮制成的，将3〜30升20〜95％乙醇加入1kg干燥的皮中，在25〜80℃下提取1〜12小时，过滤提取物，冷凝 在减压下，其中柑橘包括橙，柠檬，橘子，葡萄柚或柚子。
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公开(公告)号：KR1020010015494A
公开(公告)日：2001-02-26
申请号：KR1020000058704
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A hypotensive composition containing a bioflavonoid compound is provided to use itself as a therapeutic agent for glycosemia or as a health food. CONSTITUTION: A hypotensive composition comprises an effective amount, preferably, 0.01-50 wt.% of bioflavonoid of formula (1) and a pharmaceutical acceptable carrier thereof. The flavonoids consist in citrus fruits such as orange, lemon, citron, grapefruit and the like. The composition containing the flavonoid compounds is useful to treat glycosemia. To drop the blood sugar level, the flavonoid compound of formula (1) can be added to foods, for example meats, beverages, snacks, chocolates etc. In the formula (1), R1 is OH, rutinosyl or rhaminosyl group; R2 is H, OH or rutinosyl group; R3 is H or OH group; R4 is OH or methoxy group; X is single bond or double bond.
Abstract translation: 目的：提供含有生物类黄酮化合物的低血压组合物作为糖血症的治疗剂或作为保健食品。 构成：低血压组合物包含有效量，优选0.01-50重量％的式（1）的生物类黄酮及其药学上可接受的载体。 黄酮类化合物包括橙子，柠檬，柚子，葡萄柚等柑橘类水果。 含有类黄酮化合物的组合物可用于治疗糖血症。 为了降低血糖水平，式（1）的类黄酮化合物可以加入到食品中，例如肉类，饮料，小吃，巧克力等。在式（1）中，R 1是OH，芸香酰基或脱氨基糖基; R2是H，OH或芸香糖基; R3是H或OH基; R4是OH或甲氧基; X是单键或双键。
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44.发明公开디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 失效含有二氢DI UL UL UL UL UL A A A A A A A A A A A A A A A A A A A A A A A A
公开(公告)号：KR1020010007625A
公开(公告)日：2001-01-26
申请号：KR1020000058789
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: PURPOSE: A composition containing diosmin is provided for preventing and treating ateriosclerosis and hyperlipemia, thereby adhesion of macrophage-lipid complex on inner layer of artery is strongly inhibited, the amounts of cholesterol and fat in serum is decreased, and the activity of ACAT and HMG-CoA reductase is inhibited. CONSTITUTION: The amount of cholesterol in serum can be decreased by inhibiting the activities of acyl CoA:cholesterol-o-acyltransferase(ACAT) in liver, cholesterol ester transfer protein(CETP) transferring cholesterol between lipid proteins, 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) relating to biosynthesis of cholesterol in liver. Diosmin(C28H32O15, M.W. 608.55) may be obtained from vegetables and oranges or be synthesized. The composition containing an effective amount of diosmin, that is, 0.1 to 500 mg/kg, preferably 1 to 100 mg/kg a day, is orally or topically administrated into a patient and the dose thereof may be variable by patient's age, weight, sex, health, diet, severity of disease, and so on. The composition containing diosmin may be added into foods and drinks in an amount of 0.01 to 10 wt.%, preferably 0.1 to 5 wt.% of diosmin.
Abstract translation: 目的：提供含有diosmin的组合物，用于预防和治疗动脉硬化和高脂血症，从而强烈抑制巨噬细胞 - 脂质复合物对动脉内层的粘附，血清中胆固醇和脂肪的含量降低，ACAT和HMG的活性 -CoA还原酶被抑制。 构成：通过抑制肝脏中酰基CoA：胆固醇 - 邻 - 酰基转移酶（ACAT），胆固醇酯转移蛋白（CETP）在脂质蛋白，3-羟基-3-甲基戊二醛之间转运胆固醇的活性，可以降低血清中的胆固醇含量 辅酶A（HMG-CoA）涉及胆固醇在肝脏中的生物合成。 Diosmin（C28H32O15，M.W. 608.55）可以从蔬菜和橙子中获得或被合成。 将包含有效量的二糖苷的组合物，即每天0.1至500mg / kg，优选1至100mg / kg，口服或局部施用于患者，其剂量可以根据患者的年龄，体重， 性别，健康，饮食，疾病严重程度等。 含有diosmin的组合物可以以diosmin的0.01〜10重量％，优选0.1〜5重量％的量添加到食品和饮料中。
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公开(公告)号：KR1020000073945A
公开(公告)日：2000-12-05
申请号：KR1019990017558
申请日：1999-05-17
Applicant: 한국과학기술연구원
IPC: A61K31/335
Abstract: PURPOSE: A haematin substance has characteristically an LDL(low density lipoprotein)-antioxidation, reduces the concentration of cholesterol in blood, and inhibits the activity of liver microsome ACAT(acyl-CoA: cholesterol acyl-transferase). Thereby, the pharmaceutical composition containing the haematin has an excellent effect for treating or protecting specific diseases such as hyperlipidemia or arteriosclerosis. CONSTITUTION: The haematin used is conventionally derivable from Heartwood of Caesalpinia sappan, or is available industrially. The pharmaceutical composition is used to treat or protect hyperlipidemia or arteriosclerosis by using usual haematin in drug, beverage or food.
Abstract translation: 目的：血红素物质具有LDL（低密度脂蛋白） - 抗氧化作用，降低血液中胆固醇的浓度，并抑制肝微粒体ACAT（酰基辅酶A：胆固醇酰基转移酶）的活性。 因此，含有血红素的药物组合物对治疗或保护特异性疾病如高脂血症或动脉硬化具有优异的效果。 构成：所使用的血红素通常衍生自凯撒山茱萸的心材，或在工业上可用。 药物组合物用于通过在药物，饮料或食物中使用普通血红素来治疗或保护高脂血症或动脉硬化。
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Patent Agency Ranking
公开(公告)号：KR1020000058219A
公开(公告)日：2000-09-25
申请号：KR1020000028977
申请日：2000-05-29
Applicant: 한국과학기술연구원
IPC: A61K31/35
Abstract: PURPOSE: A composition containing hesperidin or hesperetin for inhibition of the platelet coagulation is provided, which prevents coagulation of platelets caused by exposed collagen when blood vessel endothelial cells is damaged; so which can prevents and cures formation of atheroma, or thrombosis; and which can be used in a medicine and food. CONSTITUTION: A hesperidin or hesperetin is extracted from oranges(a grapefruit, a citron, a lemon, a orange, etc) or manufactured from well-known synthetic process. A pharmaceutical composition as an inhibitor to platelet coagulation comprises of naringin or naringenin as an effective ingredient and pharmaceutically acceptable carriers, which can also contains diluents, disintegrators, sweeteners, lubricants, perfume; and which can be made in the form of tablets, capsules, powders, suspensions, emulsions, syrup, solution or parenteral preparations. A dosage of the composition for inhibition of the platelet coagulation containing naringin or naringenin is 0.5-100mg/kg, desirably 2-10mg/kg. The hesperidin or hesperetin can be added in food or beverages with same purposes.
Abstract translation: 目的：提供含有用于抑制血小板凝血的橙皮苷或橙皮素的组合物，其防止血管内皮细胞损伤时由胶原蛋白引起的血小板凝结; 因此可以预防和治愈动脉粥样化的形成或血栓形成; 并可用于医药和食品。 构成：橙子（葡萄柚，香橼，柠檬，橙子等）中提取橙皮苷或橙皮素，或由熟知的合成方法制成。 作为血小板凝血抑制剂的药物组合物包含柚皮苷或柚皮苷作为有效成分和药学上可接受的载体，其还可以含有稀释剂，崩解剂，甜味剂，润滑剂，香料; 并且其可以以片剂，胶囊，粉末，悬浮液，乳剂，糖浆，溶液或肠胃外制剂的形式制成。 用于抑制含有柚皮苷或柚皮苷的血小板凝血的组合物的剂量为0.5-100mg / kg，优选为2-10mg / kg。 橙皮苷或橙皮素可以添加到具有相同目的的食品或饮料中。
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公开(公告)号：KR1020000026393A
公开(公告)日：2000-05-15
申请号：KR1019980043909
申请日：1998-10-20
Applicant: 한국과학기술연구원
IPC: A61K31/35
CPC classification number: A61K31/352 , A61K31/7034 , A61K31/704
Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.
Abstract translation: 目的：提供一种用于增加血清高密度脂蛋白含有生物类黄酮的组合物，可用于预防和治疗心脏循环系统疾病。 构成：用于增加高密度脂蛋白的医药组合物包括（i）有效量的以下通式（I）的生物类黄酮或含有它们的植物提取物，其中每个R 1 -R 9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的苯基） ），具有5-9个碳原子的环烷氧基，其被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代，具有5-9个碳原子的环烷基羰基氧基，被一至三个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一个 至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。
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公开(公告)号：KR100213899B1
公开(公告)日：2000-03-15
申请号：KR1019990002202
申请日：1999-01-25
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: 본 발명은 감귤류 과피 추출물, 이로부터 분리 정제된 헤스페리딘 또는 나린진을 함유하는 심혈관 질환 예방 및 치료제 조성물에 관한 것으로, 감귤류 과피 추출물 및 이로부터 분리 정제된 헤스페리딘 및 나린진은 HMG-CoA 환원효소의 활성을 저해하여 혈중 콜레스테롤 농도를 저하시킴으로써 심장병, 동맥경화증 등의 심혈관 질환의 예방 및 치료제로 유용하게 사용될 수 있다.
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公开(公告)号：KR100240199B1
公开(公告)日：2000-01-15
申请号：KR1019970034195
申请日：1997-07-22
Applicant: 한국과학기술연구원
IPC: C07C49/255 , A61K31/335
Abstract: 본 발명은 생강(
Zingiberis Rhizoma )으로부터 추출된 하기 화학식 1 또는 2의 화합물을 포함하는 콜레스테릴 에스터 전이 단백질(cholesteryl ester transfer protein, CETP) 활성저해용 조성물 또는 고콜레스테롤 혈증에 기인한 심혈관 질환 예방 및 치료용 조성물에 관한 것이다.-
公开(公告)号：KR1019990079922A
公开(公告)日：1999-11-05
申请号：KR1019980012818
申请日：1998-04-10
Applicant: 한국과학기술연구원
IPC: A61K36/725 , A61K36/752 , A61P3/06 , A61P9/12
Abstract: 본 발명은 대추 추출물 및 감귤류 과피 추출물을 포함하는 지질대사 개선 및 혈압강하용 조성물에 관한 것으로, 본 발명의 조성물은 의약용 및 식품용 조성물을 포함한다. 대추 추출물 및 감귤류 과피 추출물을 포함하는 본 발명의 조성물은, 동물에 투여되었을 때 간 질환, 고혈압증, 동맥경화증, 고지혈증 등의 성인병 및 암 예방 등의 효과를 나타낼 수 있다.
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