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公开(公告)号：KR100367575B1
公开(公告)日：2003-01-10
申请号：KR1020000041597
申请日：2000-07-20
Applicant: 한국과학기술연구원
IPC: A01G31/00
Abstract: 콩나물류의 부패가 일어나지 않아 위생적이고 생산성이 높음과 아울러 폐수에 의한 환경오염문제가 없는 콩나물류 재배방법 및 그 장치에 관한 것으로, 콩나물 재배부로부터 배출된 오염물질 내지 불순물이 포함된 재배수에 응집제를 투입하여 오염물질 내지 불순물을 응집시켜 슬러지가 되게 하는 단계와, 응집된 슬러지를 포함한 재배수를 DAF처리하여 슬러지를 제거하는 단계와, 슬러지가 제거된 깨끗한 재배수를 상기 콩나물 재배부로 재공급하는 단계를 구비하는 것을 특징으로 하는 콩나물류 재배방법과 그를 실현하기 위한 장치가 제공된다.
Abstract translation: 目的：提供一种豆芽的培育方法和装置，该方法和装置能够防止豆芽在处理后通过循环用水而防止豆腐腐烂，该方法和装置可防止环境污染，提高生产率并减少用水量。 组成：在含有从豆芽培养部分（1）排出的污染物或杂质的废水中，在溶解气浮（DAF）罐（3）中引入混凝剂以凝结污染物或杂质，从污泥 - 通过DAF处理废水和处理后的含水废水，用消毒剂对废水进行灭菌并向其中倒入无机营养素后，再将其供给豆芽的培养部分。 凝固剂和防腐剂的浓度分别为1至20ppm和0.1至10ppm。
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公开(公告)号：KR1020020087570A
公开(公告)日：2002-11-23
申请号：KR1020010026194
申请日：2001-05-14
Applicant: 한국과학기술연구원 , 주식회사 엔에스케이텍
IPC: A61K36/068 , A61P3/10
Abstract: PURPOSE: A method for cultivation of Paecilomyces Japonica using a silkworm without a pupa as a host and a freeze drying method is provided. Therefore, a product having an excellent therapeutic effect on diabetic is produced with high productivity without causing the depletion of nutrients. CONSTITUTION: In the process for artificial cultivation of Paecilomyces Japonica, a 5 day old silkworm as a host is subjected to sterilization using chlorine dioxide water with a concentration of 1 to 5ppm without using heat treatment, a compound selected from the group consisting of silk amino acid, sugar and a mixture thereof is added to a medium for cultivation thereof, and then the silkworm is freeze dried and killed through an electric shock method.
Abstract translation: 目的：提供使用没有蛹作为宿主的蚕培养拟青藓的方法和冷冻干燥方法。 因此，以高生产率生产对糖尿病具有优异治疗效果的产品，而不会导致营养物质的消耗。 构成：在人造培养拟青藓的过程中，将5日龄的蚕作为宿主，使用浓度为1〜5ppm的二氧化氯水进行灭菌，不用热处理，选自丝氨基 酸，糖及其混合物加入到培养基中，然后通过电击法将蚕冷冻干燥灭活。
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公开(公告)号：KR1020020005863A
公开(公告)日：2002-01-18
申请号：KR1020000039341
申请日：2000-07-10
Applicant: 한국과학기술연구원
IPC: C01B11/02
CPC classification number: C01B11/024 , B01J19/006 , B01J19/1893 , B01J2219/00164 , B01J2219/00177 , B01J2219/00763
Abstract: PURPOSE: A method for preparing chlorine dioxide in high yield is accomplished by proper adjustment of the supply ratio of sodium chlorite and chlorine, by which hydrogen-ion concentration condition is optimized. The chlorine dioxide, when applied to cooling water, showed excellent bactericidal effect against Legionella pneumophila when applied to cooling water. In addition, chlorine dioxide has proven to be effective in eliminating alien algae in cultivating lava. CONSTITUTION: In the generation of chlorine dioxide using sodium chlorite and chlorine, by using a flowmeter and a chemical pump, Cl2 supply rate and NaClO2 supply rate are controlled to adjust pH in the range 1.9 to 2.0. For the smooth dissolving of chlorine gas into sodium chlorite solution, chlorine gas is supplied through glass wool(7), and a baffle(8) is installed to be perpendicular to a sodium chlorite/chlorine inlet. The baffle plays role in converting laminar flow to turbulent flow within short time.
Abstract translation: 目的：通过适当调整亚氯酸钠和氯的供应比，通过优化氢离子浓度条件来实现高产量制备二氧化氯的方法。 当应用于冷却水时，二氧化氯在用于冷却水时对嗜肺军团病菌显示出极好的杀菌作用。 此外，二氧化氯已被证明有效地消除培养熔岩中的外来藻类。 构成：使用亚氯酸钠和氯生成二氧化氯，通过使用流量计和化学泵，控制Cl2供应速率和NaClO2供应速率，调节pH在1.9至2.0。 为了将氯气平滑溶解在亚氯酸钠溶液中，氯气通过玻璃棉（7）供应，挡板（8）安装成与亚氯酸钠/氯气入口垂直。 挡板在短时间内将层流转化为湍流的作用。
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公开(公告)号：KR1020000051067A
公开(公告)日：2000-08-16
申请号：KR1019990001305
申请日：1999-01-18
Applicant: 한국과학기술연구원
IPC: C07D473/00
Abstract: PURPOSE: A purine compound having a substitutent group at the C-8 position is provided which is expected to be useful as an inhibitor of cyclin-dependent kinase. CONSTITUTION: A purine compound represented by the formula 1 having a substitutent group at the C-8 position is prepared, Thus, urea and ethylisocyanoacetate are subjected to heating reflux in the presence of a base to give a compound of formula 2, which is subjected to heating reflux after nitration and treated with sodium hydrosulfide to give a compound of formula 3, which is subjected to reaction continuously to give the title compound. In formula, R1 is methyl or phenyl; R2 is ethanolamine, or 2-amino-3-methyl-1-butanol.
Abstract translation: 目的：提供在C-8位置具有取代基的嘌呤化合物，其预期可用作细胞周期蛋白依赖性激酶的抑制剂。 构成：制备在C-8位具有取代基的式1表示的嘌呤化合物。因此，在碱的存在下，将脲和乙基异氰酸乙酯进行加热回流，得到式2的化合物， 硝化后加热回流并用氢硫化钠处理，得到式3的化合物，其连续进行反应，得到标题化合物。 在式中，R 1是甲基或苯基; R2是乙醇胺，或2-氨基-3-甲基-1-丁醇。
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Patent Agency Ranking
公开(公告)号：KR1020000051061A
公开(公告)日：2000-08-16
申请号：KR1019990001299
申请日：1999-01-18
Applicant: 한국과학기술연구원
IPC: C07D477/00 , C07D487/04
Abstract: PURPOSE: A thiol derivative having a novel bicyclic and 1-beta-methyl-carbaphenem having them as a substituent group at its 2-position are provided which are useful for resolving the reduction of activity of conventional carbaphenem by DHP-1. CONSTITUTION: A bicyclic thiol derivative of formula (1) and 1-beta-methyl-2-thio based carbaphenem of formula (2) having two methyl groups at its 2-position are described. In formula, R denotes H, C1-6 lower alkyl, C1-6 lower cycloalkyl, aryl, benzyl, or amino group-substituted C1-6 lower alkyl. Preferably the lower alkyl is methyl, ethyl, propyl, cyclopropylmethyl and the amino group-substituted C1-6 lower alkyl is amino ethyl.
Abstract translation: 目的：提供一种具有新的双环和1-β-甲基 - 碳青霉烯在其2-位具有取代基的硫醇衍生物，可用于解决通过DHP-1降低常规碳青霉烯酮的活性。 描述：描述了在其2位具有两个甲基的式（1）的双环硫醇衍生物和式（2）的1-β-甲基-2-硫基碳代苯并芬酮。 在式中，R表示H，C 1-6低级烷基，C 1-6低级环烷基，芳基，苄基或氨基取代的C 1-6低级烷基。 优选地，低级烷基是甲基，乙基，丙基，环丙基甲基，氨基取代的C 1-6低级烷基是氨基乙基。
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公开(公告)号：KR1020000020032A
公开(公告)日：2000-04-15
申请号：KR1019980038442
申请日：1998-09-17
Applicant: 한국과학기술연구원
IPC: C07C321/04
Abstract: PURPOSE: Title derivatives useful as radioactive pharmaceuticals are prepared which can extend a residual time in heart, and minimize a radioactive disturbance. CONSTITUTION: 1,12-Dodecane diol is alcohol-substituted by bromic acid to give 12-bromo-dodecane-1-ol, and protected by tetrahydropyrane. Obtained dodecane, 2-ethyl-4,4-dimethyl-2-oxazoline and n-butyl lithium are reacted to give 2(R/S)-(4,4-dimethyl-2-oxazoline-2-yl)-12-tetrahydropyranyl oxy-tetradecane, and esterified with sulfuric acid to give ethyl-2(R/S)-methyl-12-hydroxytetradecaneate. Obtained tetradecaneate is protected to give ethyl-2(R/S)-methyl-14-tetra butyl dimethyl silyloxy-tetradecaneate, followed by reduction with lithium aluminum hydride to give 2(R/S)-methyl-14-t-butyl dimethyl silyloxy-tetradecane-1-ol, tosylated by tosyl chloride, and to give 3(R/S)-methyl-15-t-butyl dimethyl silyloxy-pentadecane-nitrile by substituting with sodium cyanide. Obtained nitride is treated with 1N-hydrochloric acid, hydrolyzed and mesylated to give 16-methane sulfonyl-3-methyl-pentadecanic acid. The pentadecanic acid is brominated, followed by reaction of thiourea and NaOH to give 15-mercapto-3-methyl-pentadecanic acid(formula 1).
Abstract translation: 目的：制备用作放射性药物的标题衍生物，其可以延长心脏中的残留时间，并使放射性干扰最小化。 构成：1,12-十二烷二醇被溴酸醇取代，得到12-溴 - 十二烷-1-醇，并用四氢吡喃保护。 获得的十二烷，2-乙基-4,4-二甲基-2-恶唑啉和正丁基锂反应，得到2（R / S） - （4,4-二甲基-2-恶唑啉-2-基） 四氢呋喃基氧基十四烷，并用硫酸酯化，得到乙基-2（R / S） - 甲基-12-羟基十四烷酸酯。 得到的十四烷酸乙酯得到乙基-2（R / S） - 甲基-14-四丁基二甲基甲硅烷氧基 - 十四烷酸酯，然后用氢化铝锂还原，得到2（R / S） - 甲基-14-叔丁基二甲基 甲硅烷氧基 - 十四烷-1-醇，用甲苯磺酰氯甲磺酰化，并用氰化钠代替得到3（R / S） - 甲基-15-叔丁基二甲基甲硅烷氧基 - 十五烷腈。 得到的氮化物用1N盐酸处理，水解和甲磺酰化得到16-甲磺酰基-3-甲基 - 十五烷酸。 将十五烷酸溴化，随后用硫脲和NaOH反应，得到15-巯基-3-甲基 - 十五烷酸（式1）。
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公开(公告)号：KR100148029B1
公开(公告)日：1998-08-17
申请号：KR1019930021855
申请日：1993-10-20
Applicant: 한국과학기술연구원
IPC: C07C265/06 , A61K49/02
Abstract: 본 발명은 신규한 에틸 3-이소시아노 부티레이트 및 의학진단용 영상화제로서 유용한 그의 테크네슘 착화합물에 관한 것이다. 본 발명의 에틸 3-이소시아노 부티레이트는 테크네슘과의 표지 효율이 우수하고 특히 심장/허파 업테이크 비율이 우수하여 배경 장기에 대한 좋은 영상을 얻을 수 있다.
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公开(公告)号：KR100148010B1
公开(公告)日：1998-08-17
申请号：KR1019900010307
申请日：1990-07-07
Applicant: 한국과학기술연구원
IPC: C07D501/22 , C07D265/28
Abstract: 내용없음.
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公开(公告)号：KR1020110070523A
公开(公告)日：2011-06-24
申请号：KR1020090127380
申请日：2009-12-18
Applicant: 한국과학기술연구원
IPC: C12P35/00 , A61K31/545
CPC classification number: C12P35/06 , A61K31/545 , C07B2200/13 , C07D501/16 , C12N9/84 , C12Y305/01011
Abstract: PURPOSE: A method for preparing a cephalosporin antibiotics intermediate using a novel enzyme is provided to industrially synthesize an acrystalline hydrate. CONSTITUTION: A method for preparing cephalosporin antibiotic intermediate of chemical formula 1 comprises: a step of adding cresol or phenol to a compound of chemical formula 2 and stirring to deprotecting a protection group of carboxyl groups; a step of adjusting pH concentration with a base, adding Sinta CLEC-PA enzyme, and deprotecting; and a step of adjusting pH concentration with inorganic acid. The base is a carbonate alkali metal, alkali metal hydroxide, ammonia solution, or trialkyl amine.
Abstract translation: 目的：提供一种使用新型酶制备头孢菌素抗生素中间体的方法，用于工业合成结晶水合物。 构成：化学式1的头孢菌素抗生素中间体的制备方法包括：向化学式2的化合物中加入甲酚或苯酚并搅拌使保护基脱羧的步骤; 用碱调节pH浓度，添加Sinta CLEC-PA酶，脱保护的步骤; 以及用无机酸调节pH浓度的步骤。 碱为碳酸碱金属，碱金属氢氧化物，氨溶液或三烷基胺。
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