公开(公告)号：CZ20040283A3

公开(公告)日：2004-07-14

申请号：CZ20040283

申请日：2002-06-20

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  KALVIN DOUGLAS M ,  HENKIN JACK

IPC: A61K38/00 ,  A61P9/00 ,  A61P35/00 ,  C07K5/068 ,  C07K7/06 ,  C07K5/06

CPC classification number: C07K5/06086 ,  A61K38/00

公开(公告)号：CA2466326A1

公开(公告)日：2003-05-08

申请号：CA2466326

申请日：2002-10-30

Applicant: ABBOTT LAB

Inventor： BRADLEY MICHAEL F ,  HAVIV FORTUNA

IPC: A61K38/00 ,  A61P35/00 ,  C07K5/08 ,  C07K5/083 ,  C07K5/09 ,  C07K5/097 ,  C07K5/10 ,  C07K5/103 ,  C07K5/11 ,  C07K5/113 ,  C07K5/117 ,  C07K7/02 ,  C07K7/06 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08

Abstract: Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, method s of treatment using these compounds, and methods of inhibiting angiogenesis.

公开(公告)号：NZ507912A

公开(公告)日：2002-10-25

申请号：NZ50791299

申请日：1999-05-21

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  KALVIN DOUGLAS M ,  SCHNEIDER ANDREW J

IPC: A61K38/00 ,  A61P9/00 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P31/04 ,  A61P35/00 ,  C07K7/06 ,  C07K14/78 ,  A61K38/08 ,  G01N33/68

Abstract: Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8 and A9 are amino acyl residues as defined in the specification. The peptides are useful in the treatment of angiogenesis related conditions such as cancer, arthritis, psoriasis, angiogenesis of the eye associated with infection or surgery, macular degeneration and diabetic retinopathy. A method for isolating a receptor from an endothelial cell using the peptides is also described.

公开(公告)号：SK17632000A3

公开(公告)日：2001-07-10

申请号：SK17632000

申请日：1999-05-21

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  KALVIN DOUGLAS M ,  SCHNEIDER ANDREW J

IPC: A61K38/00 ,  A61P9/00 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P31/04 ,  A61P35/00 ,  C07K7/06 ,  C07K14/78 ,  A61K38/39 ,  G01N33/68

Abstract: Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8 and A9 are amino acyl residues as defined herein.

公开(公告)号：PT1232183E

公开(公告)日：2006-06-30

申请号：PT00982219

申请日：2000-11-22

Applicant: ABBOTT LAB

Inventor： FORTUNA HAVIV ,  HENKIN JACK ,  BRADLEY MICHAEL F ,  KALVIN DOUGLAS M ,  SCHNEIDER ANDREW J

IPC: A61K38/00 ,  A61P9/00 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P35/00 ,  C07K1/22 ,  C07K7/06 ,  C07K14/705 ,  C07K14/78 ,  A61K38/39

公开(公告)号：CA2582954A1

公开(公告)日：2006-04-20

申请号：CA2582954

申请日：2005-10-07

Applicant: ABBOTT LAB

Inventor： BARNES DAVID M ,  BRADLEY MICHAEL F ,  ZHANG GEOFF G ,  HENRY RODGER

IPC: C07D401/14

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

公开(公告)号：NZ532367A

公开(公告)日：2006-01-27

申请号：NZ53236702

申请日：2002-10-30

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F

IPC: A61K38/00 ,  A61P1/04 ,  A61P3/10 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P15/18 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  A61P39/00 ,  A61P43/00 ,  C07K7/06 ,  A61K38/08

Abstract: Hepta-, octa- and nanopeptides are described. The peptides are useful in pharmaceuticals for inhibiting angiogenesis and treating cancer.

公开(公告)号：BR0209758A

公开(公告)日：2005-10-04

申请号：BR0209758

申请日：2002-10-30

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F

IPC: A61K38/00 ,  A61P1/04 ,  A61P3/10 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P15/18 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  A61P39/00 ,  A61P43/00 ,  C07K7/06 ,  C07K7/00

公开(公告)号：PL374238A1

公开(公告)日：2005-10-03

申请号：PL37423802

申请日：2002-10-30

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F

IPC: A61K38/00 ,  A61P1/04 ,  A61P3/10 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P15/18 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  A61P39/00 ,  A61P43/00 ,  C07K7/06 ,  C07K7/00 ,  A61K38/04

公开(公告)号：ZA200403242B

公开(公告)日：2005-08-15

申请号：ZA200403242

申请日：2004-04-29

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F

IPC: A61P1/04 ,  A61K38/00 ,  A61P3/10 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P15/18 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  A61P39/00 ,  A61P43/00 ,  C07K7/06 ,  C07K

Abstract: Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.