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    AZATRICYCLO[3.3.1.1]DECANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS
    5.
    发明专利
    AZATRICYCLO[3.3.1.1]DECANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS 未知

    公开(公告)号：NZ577474A

    公开(公告)日：2012-03-30

    申请号：NZ57747407

    申请日：2007-11-06

    Applicant: ABBOTT LAB

    Inventor： BUNNELLE WILLIAM H ,  SCHRIMPF MICHAEL R ,  NERSESIAN DIANA L ,  SIPPY KEVIN B ,  JI JIANGUO ,  LI TAO ,  SCANIO MARC ,  SHI LEI ,  LEE CHIH-HUNG ,  ZHANG GEOFF G

    IPC: C07D451/14 ,  A61K31/395

    Abstract: Disclosed herein is an azaadamantane derivative of formula (I) wherein the substituents are as defined within the specification, specific crystalline salts thereof, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as nicotinic acetylcholine receptor ligands and are therefore useful in the treatment of conditions or disorders such as attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, schizophrenia, age-associated memory impairment (AAMI), senile dementia, AIDS dementia, Pick's disease, dementia associated with Lewy bodies, dementia associated with Down's syndrome, amyotrophic lateral sclerosis, Huntington's disease, smoking cessation, is nicotinic withdrawal syndrome, schizoaffective disorder, bipolar and manic disorders, diminished CNS function associated with traumatic brain injury, acute pain, post-surgical pain, chronic pain, inflammatory pain, and neuropathic pain.

    Octahydro-pyrrolo[3,4-b]pyrrole derivatives and their use as histamine-3 receptor ligands
    6.
    发明专利
    Octahydro-pyrrolo[3,4-b]pyrrole derivatives and their use as histamine-3 receptor ligands 未知

    公开(公告)号：NZ570235A

    公开(公告)日：2011-10-28

    申请号：NZ57023507

    申请日：2007-02-16

    Applicant: ABBOTT LAB

    Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G

    IPC: C07D487/04 ,  A61K31/407 ,  A61K31/501 ,  C07D237/14

    Abstract: Disclosed are 1-phenyl-pyrrolo[3,4-b]pyrrole derivatives as represented by the general formula (I), wherein R1 is alkyl, cycloalkyl, or (cycloalkyl)methyl; R2a-R2f each are independently hydrogen, methyl, or fluoromethyl; R3a-R3d are each independently hydrogen, alkyl, fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile; L1 is a bond, oxygen, sulfur, carbonyl, alkylene, alkylcarbonyl, alkylamino, -C(=N-Oalkyl)-, or NR4; L2 is a bond, oxygen, sulphur, carbonyl, alkylene, alkylcarbonyl, alkylamino, -C(=N-Oalkyl)-, NR5, -C(=O)NR5-, or -NR5C(=O)-; Cy1 is aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; Cy2 is aryl, cycloalkyl, cycloalkenyl, heteroaryl or heterocycle, wherein the heteroaryl or heterocycle moiety has 1, 2, or 3 heteroatoms selected from nitrogen, oxygen, and sulfur, provided that at least one heteroatom is nitrogen; and wherein the other substituents are as defined herein. Of particular importance are the compounds 2-{ 4'-[(3aR,6aR)-5- methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1'-biphenyl-4-yl} pyridazin-3(2H)-one, 2-(5-{ 4-[(3aR,6aR)-5-methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]phenyl} pyridin-2-yl)pyridazin-3(2H)-one and 2-(6-{ 4-[(3aR,6aR)-5-methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]phenyl} pyridin-3-yl)pyridazin-3(2H)-one. Further disclosed is a harmaceutical composition which comprises a compound as defined above and a pharmaceutically acceptable carrier.

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