公开(公告)号：BR0108146A

公开(公告)日：2004-01-06

申请号：BR0108146

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07B53/00 ,  C07D239/10 ,  C07D403/06 ,  C07D521/00 ,  C07D239/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：PL348033A1

公开(公告)日：2002-05-06

申请号：PL34803399

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12 ,  C07D417/00

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：AU8688901A

公开(公告)日：2002-03-13

申请号：AU8688901

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07B53/00 ,  C07D239/10 ,  C07D403/06 ,  C07D521/00 ,  C07D239/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：HU0103823A2

公开(公告)日：2002-02-28

申请号：HU0103823

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： ALLEN KIMBERLY A ,  BAUER JOHN F ,  BAUER PHILIP E ,  CHEMBURKAR SANJAY R ,  NARAYANAN BIKSHANDARKOIL A ,  PATEL KETAN ,  SALEKI-GERHARDT AZITA ,  SPIWEK HARRY O

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：SK922001A3

公开(公告)日：2001-07-10

申请号：SK922001

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12 ,  C07D417/00

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：ES2145483T3

公开(公告)日：2000-07-01

申请号：ES96931435

申请日：1996-08-27

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL HEMANTKUMAR ,  SAWICK DAVID P ,  THOMAS ALBERT V

IPC: C07C43/29 ,  C07C43/295 ,  C07C273/18 ,  C07C275/64

公开(公告)号：CA2337846A1

公开(公告)日：2000-01-27

申请号：CA2337846

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN ,  ALLEN KIMBERLY A ,  BAUER PHILIP E ,  SPIWEK HARRY O ,  BAUER JOHN F ,  NARAYANAN BIKSHANDARKOIL A ,  SALEKI-GERHARDT AZITA

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12 ,  A61K31/425

Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.

公开(公告)号：MX9801926A

公开(公告)日：1998-05-31

申请号：MX9801926

申请日：1996-08-27

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL HEMANTKUMAR H ,  SAWICK DAVID P ,  THOMAS ALBERT V

IPC: C07C43/29 ,  C07C43/295 ,  C07C273/18 ,  C07C275/64

Abstract: La presente invencion provee un procedimiento para la preparacion de un compuesto de la formula (I), en donde R es un grupo alquilo recto o ramificado de uno oa doce átomos de carbono; M representa hidrogeno o un cation farmaceuticamente aceptable; y A se selecciona de fenilo carbocíclico opcionalmente substituido.

公开(公告)号：AU2010273259A1

公开(公告)日：2012-02-09

申请号：AU2010273259

申请日：2010-07-16

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  REDDY RAJARATHMAN E ,  REAMER DOUGLAS M ,  PAVLINA JOHN T ,  ULREY STEPHEN S ,  KOTECKI BRIAN J

IPC: C07D209/42

Abstract: Processes for the preparation of (2S, 3aR, 7aS) -octahydro-1H-indole-20carboxylic acid hydrochloride starting from (1S, 2S) -2- [ (S) -1- phenylethyl amino] cyclohexyl) methanol are described.

公开(公告)号：MY145265A

公开(公告)日：2012-01-13

申请号：MYPI0402546

申请日：1999-07-16

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOR A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: SUBSTANTIALLY PURE AMORPHOUS RITONAVIR IS DISCLOSED. ALSO DISCLOSED A PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE RITANOVIR CRYSTALLINE POLYMORPH FORM I COMPRISING ADDING A SOLUTION OF RITONAVIR TO A SLURRY OF SEED CRYSTALS OF RITONAVIR CRYSTALLINE POLYMORPH FORM I IN AN ANTI-SOLVENT.