公开(公告)号：WO9834917A3

公开(公告)日：1999-01-14

申请号：PCT/US9802439

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： LEANNA M ROBERT ,  HANNICK STEVEN M ,  RASMUSSEN MICHAEL ,  TIEN JIEN-HEH J ,  BHAGAVATULA LAKSHMI ,  SINGAM PULLA REDDY ,  GATES BRADLEY D ,  KOLACZKOWSKI LAWRENCE ,  PATEL RAMESH R ,  WAYNE GREG ,  LANNOYE GREG ,  ZHANG WEIJIANG ,  TIAN ZHENPING ,  LUKIN KIRILL L ,  NARAYANAN BIKSHANDARKOR A ,  RILEY DAVID A ,  MORTON HOWARD ,  CHANG SOU-JEN

IPC: C12P7/62 ,  A61K31/52 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  C07C69/16 ,  C07C309/73 ,  C07D473/18 ,  C07D473/40 ,  C07D73/00

CPC classification number: C07D473/18

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

公开(公告)号：MY121765A

公开(公告)日：2006-02-28

申请号：MYPI9903007

申请日：1999-07-16

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOR A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: THERE IS DISCLOSED A CRYSTALLINE POLYMORPH AND A GREATER THAN 90% PURE CRYSTALLINE POLYMORPH OF (2S, 3S, 5S)-5-(N-(N-((-METHYL-N-((2-ISOPROPYL-4-THIAZOLYL)ME-THYL)AMINO)CARBONYL)-L-VALINYL)AMINO)-2-(N-((5-THIAZOLYL)METHOXYCARBONYL)AMINO)-1, 6-DIPHENYL-3-HYDROXYHEXANE. IT HAS CHARACTERISTIC PEAKS IN THE POWDER X-RAY DIFFRACTION PATTERN AT VALUES OF TWO THETA OF 8.67°± 0.1, 9.88°±0.1°, 16.11° ± 0.1°, 16.70° ± 0.1°, 17.36° ± 0.1°, 17.78° ± 0.1°, 18.40° ± 0.1°, 18.93° ± 0.1° 20.07° ± 0.1°, 20.65° ± 0.1°, 21.71° ± 0.1° AND 25.38° ± 0.1°. A PROCESS FOR THE PREPARATION OF THE GREATER THAN 90% PURE CRYSTALLINE POLYMORPH IS ALSO DISCLOSED.

公开(公告)号：MY145265A

公开(公告)日：2012-01-13

申请号：MYPI0402546

申请日：1999-07-16

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOR A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: SUBSTANTIALLY PURE AMORPHOUS RITONAVIR IS DISCLOSED. ALSO DISCLOSED A PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE RITANOVIR CRYSTALLINE POLYMORPH FORM I COMPRISING ADDING A SOLUTION OF RITONAVIR TO A SLURRY OF SEED CRYSTALS OF RITONAVIR CRYSTALLINE POLYMORPH FORM I IN AN ANTI-SOLVENT.