公开(公告)号：CA2292788A1

公开(公告)日：1998-12-17

申请号：CA2292788

申请日：1998-06-11

Applicant: ABBOTT LAB

Inventor： BILLING-MEDEL PATRICIA A ,  COHEN MAURICE ,  HODGES STEVEN C ,  GRANADOS EDWARD N ,  FRIEDMAN PAULA N ,  COLPITTS TRACEY L ,  KRATOCHVIL JON D ,  GORDON JULIAN ,  ROBERTS-RAPP LISA ,  RUSSELL JOHN C ,  KLASS MICHAEL R ,  STROUPE STEPHEN D

IPC: G01N33/574 ,  A61K39/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/6886 ,  C07K16/00

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as LS170 and transcribed from lung tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung, such as lung cancer. Also provided are antibodies which specifically bind to a LS170-encoded polypeptide or protein, and agonists or inhibitors which prevent action of tissue-specific LS170 polypeptides, which molecules are useful for the therapeutic treatment of lung diseases, tumors, or metastases.

公开(公告)号：CA2287571A1

公开(公告)日：1998-10-29

申请号：CA2287571

申请日：1998-04-23

Applicant: ABBOTT LAB

Inventor： STROUPE STEPHEN D ,  HODGES STEVEN C ,  BILLING-MEDEL PATRICIA A ,  COHEN MAURICE ,  KLASS MICHAEL R ,  KRATOCHVIL JON D ,  GRANADOS EDWARD N ,  FRIEDMAN PAULA N ,  RUSSELL JOHN C ,  GORDON JULIAN ,  ROBERTS-RAPP LISA ,  COLPITTS TRACEY L

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P13/08 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/574 ,  C07K16/00 ,  A61K38/17

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS118 and transcribed from prostate tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS118-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS118 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

公开(公告)号：CA2285039A1

公开(公告)日：1998-10-08

申请号：CA2285039

申请日：1998-03-31

Applicant: ABBOTT LAB

Inventor： RUSSELL JOHN C ,  STROUPE STEVEN D ,  HAYDEN MARK ,  GORDON JULIAN ,  KRATOCHVIL JON D ,  FRIEDMAN PAULA N ,  HODGES STEVEN C ,  BILLING-MEDEL PATRICIA A ,  COHEN MAURICE ,  KLASS MICHAEL R ,  COLPITTS TRACEY L ,  GRANADOS EDWARD N

IPC: G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N15/63 ,  A61K38/17 ,  G01N33/574 ,  G01N33/577

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：CA2232237A1

公开(公告)日：1998-02-26

申请号：CA2232237

申请日：1997-08-19

Applicant: ABBOTT LAB

Inventor： GRANADOS EDWARD N ,  ROBERTS-RAPP LISA ,  HODGES STEVEN C ,  RUSSELL JOHN C ,  BILLING-MEDEL PATRICIA A ,  KLASS MICHAEL R ,  KRATOCHVIL JON D ,  STROUPE STEVEN D ,  FRIEDMAN PAULA N ,  COHEN MAURICE ,  COLPITTS TRACEY L ,  GORDON JULIAN

IPC: G01N33/53 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N5/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/574 ,  A61K31/70 ,  A61K39/00 ,  A61K48/00 ,  C07H21/00 ,  C07K16/18 ,  G01N33/543

Abstract: A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：CA1301646C

公开(公告)日：1992-05-26

申请号：CA541923

申请日：1987-07-13

Applicant: ABBOTT LAB

Inventor： PRY TERRY A ,  GRANADOS EDWARD N

IPC: G01N33/543 ,  G01N33/538

Abstract: A method for performing a diagnostic immunoassay by a solid phase separation. To a reaction mixture of a test sample and labeled antibody, which forms a complex of any analyte present in the test sample, is added a solid phase material having a compound capable of binding any excess labeled antibody. The solid phase material is chosen to rapidly settle whereby a solid and liquid phase is formed. The liquid phase can then be extracted to measure the amount of analyte-labeled antibody present therein. (53-2068g)

公开(公告)号：DE60044119D1

公开(公告)日：2010-05-20

申请号：DE60044119

申请日：2000-01-21

Applicant: ABBOTT LAB

Inventor： BILLING-MEDEL PATRICIA A ,  COHEN MAURICE ,  COLPITTS TRACEY L ,  FRIEDMAN PAULA N ,  GORDON JULIAN ,  GRANADOS EDWARD N ,  HODGES STEVEN C ,  KLASS MICHAEL R ,  KRATOCHVIL JON D ,  RUSSELL JOHN C ,  STROUPE STEPHEN D

IPC: C07K14/47 ,  G01N33/53 ,  C07K16/18 ,  C07K16/30 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/63 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/566 ,  G01N33/574 ,  G01N33/577 ,  G01N37/00

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS322 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS322-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS322 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases

公开(公告)号：DE69739653D1

公开(公告)日：2009-12-31

申请号：DE69739653

申请日：1997-08-19

Applicant: ABBOTT LAB

Inventor： BILLING-MEDEL PATRICIA A ,  COHEN MAURICE ,  COLPITTS TRACEY L ,  FRIEDMAN PAULA N ,  GORDON JULIAN ,  GRANADOS EDWARD N ,  HODGES STEVEN C ,  KLASS MICHAEL R ,  KRATOCHVIL JON D ,  ROBERTS-RAPP LISA ,  RUSSELL JOHN C ,  STROUPE STEVEN D

IPC: C12N15/12 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/53

公开(公告)号：AT293707T

公开(公告)日：2005-05-15

申请号：AT00978231

申请日：2000-10-16

Applicant: ABBOTT LAB

Inventor： GRANADOS EDWARD N ,  SCHEFFEL CHRISTI POWELL

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/566

Abstract: Nucleic acid sequences are provided that are useful as amplification primers and hybridization probes for detecting CK19 target sequence in a test sample. The primers and probes can be employed in amplification based methods for detecting the presence of CK19 sequences in a test sample. The amplification product can be detected with the assistance of microparticle capture techniques.

公开(公告)号：CA2384917A1

公开(公告)日：2001-04-26

申请号：CA2384917

申请日：2000-10-16

Applicant: ABBOTT LAB

Inventor： SCHEFFEL CHRISTI POWELL ,  GRANADOS EDWARD N

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/566

Abstract: Nucleic acid sequences are provided that are useful as amplification primers and hybridization probes for detecting CK19 target sequence in a test sample . The primers and probes can be employed in amplification based methods for detecting the presence of CK19 sequences in a test sample. The amplification product can be detected with the assistance of microparticle capture techniques.

公开(公告)号：CA2367125A1

公开(公告)日：2000-09-28

申请号：CA2367125

申请日：2000-03-24

Applicant: ABBOTT LAB

Inventor： BILLING-MEDEL PATRICIA A ,  GRANADOS EDWARD N ,  STROUPE STEPHEN D ,  COLPITTS TRACEY L ,  RUSSELL JOHN C ,  GORDON JULIAN ,  COHEN MAURICE

IPC: G01N33/53 ,  A61K38/00 ,  C07K14/47 ,  C07K14/495 ,  C07K16/24 ,  C07K16/30 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/574 ,  A61K38/17 ,  G01N33/577 ,  C12N15/63

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptide s encoded thereby, designated as PCIGF and transcribed from prostate tissue, i s described. These sequences are useful for the detecting, diagnosing, staging , monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions o f the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PCIGF-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PCIGF polypeptide, which molecules are useful for the therapeutic treatment of prostate disease s, tumors or metastases.