公开(公告)号：DE69333230T2

公开(公告)日：2004-08-05

申请号：DE69333230

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY RAY ,  MCDOWELL DOUGLAS D ,  RUMBAUGH WILLIAM A ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

公开(公告)号：DE69330785T2

公开(公告)日：2002-06-20

申请号：DE69330785

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： SCHMIDT LINDA S ,  SPRONK ADRIAN M ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE III ,  LAGOCKI PETER A ,  MITCHELL JAMES E ,  MARTIN RICHARD R ,  MOORE LARRY E ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N33/02 ,  G01N33/483

公开(公告)号：CA2172363A1

公开(公告)日：1995-03-31

申请号：CA2172363

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N37/00

Abstract: An automated, continuous and random access analytical system, having apparat us and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodolo gies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is a lso disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assa ys of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a u nit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reacti on sequence, followed by physical transfer of the unit dose disposable to a processing wo rkstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performi ng more than one scheduled assay in any order, and assay s where more than such scheduled assays are presented. The automated, continuo us and random access analytical system is also capable o f analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：CA2613156A1

公开(公告)日：1995-03-30

申请号：CA2613156

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  VAUGHT JAMES A ,  YOST DAVID A ,  HILLS DAVID B ,  LAGOCKI PETER A ,  WINTER GARY E ,  VICKSTROM RICHARD L ,  STANTON ALYN K ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  MARTIN RICHARD R ,  OLEKSAK CARL M ,  MITCHELL JAMES E ,  SCHMIDT LINDA S ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  HENDRICK KENDALL B ,  WALKER EDNA S ,  SPRONK ADRIAN M ,  WOHLFORD ROBERT A ,  SMITH JANE B ,  RUMBAUGH WILLIAM D ,  MOORE LARRY W ,  MERRIAM RICHARD A ,  CLOONAN KEVIN M ,  SCHRIER PAUL R ,  CLARK FREDERICK L ,  CLEMENS JOHN M ,  MCDOWELL DOUGLAS D ,  HANCE ROBERT B ,  CLIFT GILBERT

IPC: G01N33/483 ,  G01N35/00 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N1/44 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00 ,  H01J49/04

Abstract: The invention discloses an automated liquid level sensing system for detecting the presence of liquid in a container, comprising an electrically conductive and movable probe positioned above said container; a signal source electrically connected to said probe, said signal source capable of energizing said probe thereby causing said probe to transmit said electrical signal at a given frequency; a receiving antenna and means for transferring said received electrical signal from said receiving antenna to an analyzing means; wherein analyzing said received electrical signal includes: (1) means for detecting changes in received signal amplitude, wherein said means for detecting changes in received signal amplitude includes:(a) means for multiplying said received signal by a reference signal, said reference signal having a frequency substantially equal to the frequency of the transmitted signal; and (b) a low pass filter through which is passed said multiplied received signal; and (2) means for measuring rate of change of said change in received signal amplitude; and means connected to said analyzing means for indicating that liquid has been detected. The invention further discloses a method of automatically detecting the presence of liquid in a container using the system of the invention. An automated liquid sensing system for use in a clinical analysis system having a pipettor for dispensing or aspirating liquid in a container, the pipettor being electrically conductive and moveable vertically into the container, using the automated liquid sensing system of the invention further comprising a means electrically connected to the pipettor for applying a RF signal thereto and causing the pipettor to radiate an electromagnetic field, the propagation of which changes when the pipettor contacts the surface of the liquid in the container is further disclosed.

公开(公告)号：CA2132960A1

公开(公告)日：1993-10-14

申请号：CA2132960

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LOGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH B JANE ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY R ,  RUMBAUGH WILLIAM ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

Abstract: 2132960 9320440 PCTABS00027 An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：CA2129246A1

公开(公告)日：1993-10-14

申请号：CA2129246

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： KANEWSKE WILLIAM J III ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  YOST DAVID A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B29C45/26 ,  B29C45/42 ,  B29D11/00 ,  B29D23/00 ,  G01N1/00 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B29D23/22

公开(公告)号：ES2271941T3

公开(公告)日：2007-04-16

申请号：ES93908571

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R

IPC: G01N21/64 ,  G01N35/02 ,  B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  G01N1/00 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/49 ,  G01N21/59 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: SE PRESENTA UN SISTEMA ANALITICO AUTOMATICO DE ACCESO CONTINUO Y ALEATORIO, QUE TIENE UN APARATO Y UNA METODOLOGIA CAPACES DE REALIZAR SIMULTANEAMENTE ANALISIS MULTIPLES DE MUESTRAS DE LIQUIDOS UTILIZANDO DIFERENTES METODOLOGIAS DE ANALISIS, Y SUMINISTRANDO UN ACCESO CONTINUO Y ALEATORIO MIENTRAS QUE REALIZA UNA PLURALIDAD DE ANALISIS SOBRE LA MISMA O DIFERENTES MUESTRAS DURANTE EL MISMO PERIODO DE TIEMPO. TAMBIEN SE PRESENTA UN METODO PARA UTILIZAR UN SISTEMA ANALITICO AUTOMATICO DE ACCESO CONTINUO Y ALEATORIO CAPAZ DE EFECTUAR SIMULTANEAMENTE ANALISIS MULTIPLES DE UNA PLURALIDAD DE MUESTRAS DE LIQUIDO EN DONDE LA CATALOGACION DE LOS DIFERENTES ANALISIS DE LA PLURALIDAD DE MUESTRAS DE LIQUIDO SE SIGUE CREANDO UNA DOSIS UNITARIA DESECHABLE Y SEPARADAMENTE TRANSFIRIENDO UNA PRIMERA MUESTRA DE LIQUIDO (26), REACTIVOS (30) A UN VASO DE REACCION (34) SIN LA INICIALIZACION DE UNA SECUENCIA DE REACCION DE ANALISIS, SIGUIENDO CON LA TRANSFERENCIA FISICA DE LA DOSIS UNITARIA DESECHABLE (34) A UNA ESTACION DE TRABAJO DE PROCESAMIENTO, EN DONDE SE CONSIGUE UNA MEZCLA DE LA DOSIS UNITARIA DESECHABLE, LOS REACTIVOS Y LA MUESTRA (34) DURANTE LA INCUBACION. EL SISTEMA ES CAPAZ DE REALIZAR MAS DE UN ANALISIS CATALOGADO EN CUALQUIER ORDEN, Y LOS ANALISIS EN LOS QUE ESTAN PRESENTES MAS DE UN ANALISIS PROGRAMADO. EL SISTEMA ANALITICO AUTOMATICO, DE ACCESO CONTINUO Y ALEATORIO ES TAMBIEN CAPAZ DE ANALIZAR LAS MEZCLAS DE REACCION INCUBADAS INDEPENDIENTEMENTE E INDIVIDUALMENTE MEDIANTE AL MENOS DOS PROCEDIMIENTOS DE ENSAYO.

公开(公告)号：CA2132960C

公开(公告)日：2006-05-02

申请号：CA2132960

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  MARTIN RICHARD R ,  MOORE LARRY W ,  SMITH B JANE ,  RUMBAUGH WILLIAM D ,  CLEMENS JOHN M

IPC: G05D23/19 ,  B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  H05B1/02

Abstract: An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiati on of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：DE69330785D1

公开(公告)日：2001-10-25

申请号：DE69330785

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： SCHMIDT LINDA S ,  SPRONK ADRIAN M ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE III ,  LAGOCKI PETER A ,  MITCHELL JAMES E ,  MARTIN RICHARD R ,  MOORE LARRY E ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N33/02 ,  G01N33/483

公开(公告)号：CA2650258A1

公开(公告)日：1995-03-30

申请号：CA2650258

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： TAYI APPARAO ,  VAUGHT JAMES A ,  KANEWSKE WILLIAM J III ,  WALKER EDNA S ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  SMITH B JANE ,  YOST DAVID A ,  PENNINGTON CHARLES D ,  CLIFT GILBERT ,  MOORE LARRY W ,  HENDRICK KENDALL B ,  MITCHELL JAMES E ,  CLARK FREDERIC L

IPC: G01N33/483 ,  G01N35/02 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparat us and methodology capable of simultaneously performing multiple assays of liqu id samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of vario us assays of the plurality of liquid samples is followed by creating a unit dose disposab le and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of t he unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtur es independently and individually by atleast two assay procedures.