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公开(公告)号:SI1418174T1
公开(公告)日:2009-08-31
申请号:SI9931030
申请日:1999-07-19
Applicant: ABBOTT LAB
Inventor: BAUER JOHN F , SALEKI-GERHARDT AZITA , CHEMBURKAR SANJAY R , PATEL KETAN , SPIWEK HARRY O
IPC: C07D277/00 , A61K31/00 , A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12
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公开(公告)号:BG110080A
公开(公告)日:2008-11-28
申请号:BG11008006
申请日:2006-09-20
Applicant: ABBOTT LAB
Inventor: BAUER JOHN , SALEKI-GERHARDT AZITA , NARAYANAN BIKSHANDARKOIL , CHEMBURKAR SANJAY , PATEL KETAN , SPIWEK HARRY , BAUER PHILIP , ALLEN KIMBERLY
IPC: C07D277/24 , A61K31/425 , A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12
Abstract: The invention relates to (2S, 3S, 5S)-5-{N-(/N-methyl-N-[/2-isopropyl-4-thiasolyl/methyl]amino/carbonyl-L-valinyl)amino]-2-{N-[/5- thiazolyl/methoxycarbonyl]amino}-1,6-diphenyl-3-hydroxyhexan} (ritonavir), in particular to essentially pure crystalline ritonavir, to methods for obtaining it, and to pharmaceutical compositions containing it. The invention relates also to a method for obtaining an essentially pure crystalline polymorphous form II of ritonavir.
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公开(公告)号:BG109682A
公开(公告)日:2007-03-30
申请号:BG10968206
申请日:2006-09-20
Applicant: ABBOTT LAB
Inventor: BAUER JOHN , SALEKI-GERHARDT AZITA , NARAYANAN BIKSHANDARKOIL , CHEMBURKAR SANJAY , PATEL KETAN , SPIWEK HARRY , BAUER PHILIP , ALLEN KIMBERLY
IPC: C07D277/24 , A61K31/425 , A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/00 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12
Abstract: The invention relates to (2S,3S,5S)-5-{N-[N-(/N-methyl-N-[/2-isopropyl-4-thiazolyl/methyl]amino}carbonyl-L-valinyl)amino]-2-{N-[/5- thiazolyl/methoxycarbonyl]amino}-1,6-diphenyl-3-hydroxyhexane} (ritonavir), in particular to essentially pure amorphous ritonavir, to methods of obtaining it, to pharmaceutical compositions containing it, as well as to a method of obtaining essentially pure crystalline polymorphous forms I and II of ritonavir.
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公开(公告)号:NO318385B1
公开(公告)日:2005-03-14
申请号:NO20010298
申请日:2001-01-18
Applicant: ABBOTT LAB
Inventor: BAUER JOHN F , SALEKI-GERHARDT AZITA , NARAYANAN BIKSHANDARKOIL A , CHEMBURKAR SANJAY , PATEL KETAN , SPIWEK HARRY O , BAUER PHILIP E , ALLEN KIMBERLY A
IPC: A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12
Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.
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公开(公告)号:DE69915628D1
公开(公告)日:2004-04-22
申请号:DE69915628
申请日:1999-07-19
Applicant: ABBOTT LAB
Inventor: BAUER F , SALEKI-GERHARDT AZITA , NARAYANAN A , CHEMBURKAR R , PATEL KETAN , SPIWEK O , BAUER E , ALLEN A
IPC: A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12 , A61K31/425
Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.
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公开(公告)号:DK0858324T3
公开(公告)日:2003-09-29
申请号:DK96937699
申请日:1996-10-18
Applicant: ABBOTT LAB
Inventor: SALEKI-GERHARDT AZITA , ERNEST R KESKE
IPC: A61K9/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K47/32
Abstract: The present invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.
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公开(公告)号:CA2433962A1
公开(公告)日:2002-10-28
申请号:CA2433962
申请日:2002-07-19
Applicant: ABBOTT LAB
Inventor: RAFELDT RICK , SALEKI-GERHARDT AZITA
IPC: A61K31/7048 , A61K31/717 , A61P31/04
Abstract: Abridged clarithromycin antibacterial compositions and methods for making t he same are disclosed
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公开(公告)号:PL348033A1
公开(公告)日:2002-05-06
申请号:PL34803399
申请日:1999-07-19
Applicant: ABBOTT LAB
Inventor: BAUER JOHN F , SALEKI-GERHARDT AZITA , NARAYANAN BIKSHANDARKOIL A , CHEMBURKAR SANJAY R , PATEL KETAN , SPIWEK HARRY O , BAUER PHILIP E , ALLEN KIMBERLY A
IPC: A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12 , C07D417/00
Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.
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公开(公告)号:HU0103823A2
公开(公告)日:2002-02-28
申请号:HU0103823
申请日:1999-07-19
Applicant: ABBOTT LAB
Inventor: ALLEN KIMBERLY A , BAUER JOHN F , BAUER PHILIP E , CHEMBURKAR SANJAY R , NARAYANAN BIKSHANDARKOIL A , PATEL KETAN , SALEKI-GERHARDT AZITA , SPIWEK HARRY O
IPC: A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12
Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.
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公开(公告)号:SK922001A3
公开(公告)日:2001-07-10
申请号:SK922001
申请日:1999-07-19
Applicant: ABBOTT LAB
Inventor: BAUER JOHN F , SALEKI-GERHARDT AZITA , NARAYANAN BIKSHANDARKOIL A , CHEMBURKAR SANJAY R , PATEL KETAN , SPIWEK HARRY O , BAUER PHILIP E , ALLEN KIMBERLY A
IPC: A61K31/426 , A61K31/427 , A61P31/18 , A61P37/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D417/12 , C07D417/00
Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.
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