公开(公告)号：EP2331516A1

公开(公告)日：2011-06-15

申请号：EP09791365.1

申请日：2009-08-11

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

IPC: C07D261/14 ,  C07D407/06 ,  C07D417/06 ,  C07D285/135 ,  A61K31/433 ,  A61P29/00

CPC classification number: C07D261/14 ,  C07D285/135 ,  C07D407/06 ,  C07D417/06

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein Y, X
1 , X
2 , X
3 , R
1 , and R
2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP1373220A1

公开(公告)日：2004-01-02

申请号：EP02731130.7

申请日：2002-03-06

Applicant: ABBOTT LABORATORIES

Inventor： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  KOLASA, Teodozyj ,  ROHDE, Jeffrey, J. ,  PATEL, Meena, V. ,  BRIONI, Jorge, D.

IPC: C07D235/06 ,  A61P15/10 ,  A61K31/4188

CPC classification number: C07D401/12 ,  C07D235/14 ,  C07D401/14 ,  C07D417/12

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP1007515A1

公开(公告)日：2000-06-14

申请号：EP98938451.6

申请日：1998-08-10

Applicant: Abbott Laboratories

Inventor： BLACK, Lawrence, A. ,  BASHA, Anwer ,  KOLASA, Teodozyj ,  KORT, Michael, E. ,  LIU, Huaqing ,  McCARTY, Catherine, M. ,  PATEL, Meena, V. ,  ROHDE, Jeffrey, J.

IPC: C07D237/14 ,  C07D401/06 ,  C07D403/06 ,  C07D237/18 ,  C07D409/06 ,  C07D413/06 ,  C07D405/06 ,  A61K31/50 ,  C07F11/00

CPC classification number: C07D401/06 ,  C07D237/14 ,  C07D237/18 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D417/06

Abstract: The present invention describes pyridazinone compounds which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX/2), COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：EP2346843A2

公开(公告)日：2011-07-27

申请号：EP09792301.5

申请日：2009-09-08

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  PEDDI, Sridhar

IPC: C07D277/46 ,  C07D417/06 ,  C07D417/14 ,  A61K31/427 ,  A61P29/00

CPC classification number: C07D417/06 ,  C07D277/46 ,  C07D417/14

Abstract: The present application relates to cannabinoid receptor ligands of formula (I), wherein X
1 , A
1 , R
x , R
2 , R
3 , R
4 , and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2222165A1

公开(公告)日：2010-09-01

申请号：EP08852528.2

申请日：2008-11-20

Applicant: ABBOTT LABORATORIES

Inventor： FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST,Jennifer, M. ,  NELSON, Derek, W.

IPC: A01N43/42

CPC classification number: C07D417/12 ,  C07D277/46 ,  C07D417/06 ,  C07D513/04 ,  C07D513/20

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (I). wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (II). wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2219629A1

公开(公告)日：2010-08-25

申请号：EP08837396.4

申请日：2008-10-08

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  DART, Michael J. ,  NELSON, Derek W. ,  LI, Tongmei ,  LIU, Bo ,  KOLASA, Teodozyj ,  FROST, Jennifer ,  WANG, Xueqing ,  LATSHAW, Steven, P.

IPC: A61K31/015 ,  A61P43/00

CPC classification number: C07D405/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates compounds of formula (I), as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Abstract translation: 本发明涉及如说明书中所定义的式（I）化合物，包含此类化合物的药物组合物，以及使用此类化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：EP2038266A2

公开(公告)日：2009-03-25

申请号：EP07797862.5

申请日：2007-05-30

Applicant: ABBOTT LABORATORIES

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00

CPC classification number: C07D277/82 ,  C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D417/06 ,  C07D417/12 ,  C07D477/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP1373220B1

公开(公告)日：2007-05-30

申请号：EP02731130.7

申请日：2002-03-06

Applicant: ABBOTT LABORATORIES

Inventor： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  KOLASA, Teodozyj ,  ROHDE, Jeffrey, J. ,  PATEL, Meena, V. ,  BRIONI, Jorge, D.

IPC: C07D235/06 ,  A61P15/10 ,  A61K31/4188

CPC classification number: C07D401/12 ,  C07D235/14 ,  C07D401/14 ,  C07D417/12

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP1345608A2

公开(公告)日：2003-09-24

申请号：EP01995843.8

申请日：2001-11-21

Applicant: Abbott Laboratories

Inventor： BRIONI, Jorge, D. ,  KOLASA, Teodozyj ,  HSIEH, Gin, C. ,  DONNELLY-ROBERTS, Diane, L.

IPC: A61K31/496 ,  A61P15/02 ,  A61P15/10

CPC classification number: A61K45/06 ,  A61K31/495 ,  A61K31/496 ,  A61K2300/00

Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.