公开(公告)号：DK2411528T3

公开(公告)日：2015-12-14

申请号：DK10756991

申请日：2010-03-29

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  CHENG TING-JEN R ,  HSU CHE-HSIUNG

IPC: C07H13/04 ,  C07H1/00

公开(公告)号：CA2950433A1

公开(公告)日：2015-12-03

申请号：CA2950433

申请日：2015-05-27

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI

IPC: A61K39/395

Abstract: The present disclosure relates to a novel class of anti-TNFa monoclonal antibodies or antigen binding fragments comprising a homogeneous population of anti-TNFa IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-TNFa monoclonal antibodies by Fc glycoengineering. The glycoantibodies of the invention may have improved therapeutic values compared to the corresponding monoclonal antibodies that have not been glycoengineered.

公开(公告)号：NZ550945A

公开(公告)日：2010-04-30

申请号：NZ55094505

申请日：2005-05-03

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  JAN JIA-TSRONG

IPC: A01N47/10 ,  A61K31/27 ,  C07C261/00 ,  C07C269/00 ,  C07C271/00

Abstract: Disclosed is a compound of formula (I), or a salt thereof, wherein R5 and R11 are alkyl substituted with aryl, and wherein the rest of the substituents are as defined in the specification. Also disclosed is the use of the above compound for treating an infection with a coronavirus.

公开(公告)号：DK3250590T3

公开(公告)日：2021-10-18

申请号：DK16744256

申请日：2016-01-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WU HAN-CHUNG ,  WU CHUNG-YI

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C12P19/14

公开(公告)号：AU2016211176B2

公开(公告)日：2021-01-28

申请号：AU2016211176

申请日：2016-01-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  MA CHE ,  WU HAN-CHUNG

IPC: C07K16/00 ,  A61K39/42 ,  C07K16/10 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.

公开(公告)号：AU2019203313B2

公开(公告)日：2020-04-30

申请号：AU2019203313

申请日：2019-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/04 ,  C12N9/10

Abstract: Abstract A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

公开(公告)号：AU2018200094B2

公开(公告)日：2019-02-14

申请号：AU2018200094

申请日：2018-01-05

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/04 ,  C12N9/10

Abstract: Abstract A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

公开(公告)号：CA2959030C

公开(公告)日：2018-12-18

申请号：CA2959030

申请日：2015-08-21

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  LEE HSIN-YU

IPC: C08B5/00 ,  A61K39/00 ,  A61K39/385 ,  C07K1/113 ,  C07K14/34 ,  C07K16/30

Abstract: This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b) an adjuvant. The one or more glycan is each a Globo H derivative.

公开(公告)号：CA3042447A1

公开(公告)日：2018-05-17

申请号：CA3042447

申请日：2017-11-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI

IPC: C12N7/00 ,  A61K39/00 ,  A61K39/145 ,  C07K14/005 ,  C12N9/24

Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.

公开(公告)号：AU2016211176A1

公开(公告)日：2017-08-10

申请号：AU2016211176

申请日：2016-01-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  MA CHE ,  WU HAN-CHUNG

IPC: C07K16/00 ,  A61K39/42 ,  C07K16/10 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.