公开(公告)号：JPH0192230A

公开(公告)日：1989-04-11

申请号：JP5615087

申请日：1987-03-11

Applicant: AGENCY IND SCIENCE TECHN

Inventor： MATSUDA HIROO ,  NAKANISHI HACHIRO ,  TANAKA YOSHIO ,  NAKAYAMA KAZUO ,  KATO MASAO

IPC: B29C39/42 ,  C08F38/00 ,  C08G69/26 ,  C08J3/24 ,  C08J5/00

Abstract: PURPOSE:To easily obtain the titled molded article composed of a highly crystalline polymer having a network structure containing two-dimensional covalent bond, by carrying out solid-phase polymerization of the diacetylene part of a diacetylene nylon chloride and subjecting the chloride to thermal polycondensation in a mold. CONSTITUTION:The diacetylene part of a diacetylene nylon chloride of formula I [R1 and R2 are (substituted) (cyclo)alkylene or arylene] is subjected to solid- phase polymerization. The objective molded article can be produced by the thermal polycondensation of the polymerized chloride in a mold under a pressure of 0.5X10 -15X10 atm. at 100-400 deg.C. The chloride of formula I is preferably produced usually by mixing diacetylenecarboxylic acid of formula II with equimolar amount of diamine of formula III. The solid-phase polymerization of the diacetylene part is carried out, e.g., by sealing the chloride of formula I in vacuum and irradiating with gamma-ray of cobalt 60.

公开(公告)号：JPS62250276A

公开(公告)日：1987-10-31

申请号：JP9539586

申请日：1986-04-23

Applicant: AGENCY IND SCIENCE TECHN ,  SENKO KK VAN

Inventor： TANAKA YOSHIO ,  HIRASA OKIHIKO ,  BAN MINORU

IPC: D06P3/04 ,  D06M13/02 ,  D06M13/03 ,  D06M13/11 ,  D06M13/165 ,  D06M13/224 ,  D06M13/244 ,  D06M13/248 ,  D06M13/282 ,  D06M13/322 ,  D06M13/325 ,  D06M13/402 ,  D06M14/06 ,  D06M101/00 ,  D06M101/02 ,  D06M101/10 ,  D06P5/00

公开(公告)号：JPH04117284A

公开(公告)日：1992-04-17

申请号：JP12320190

申请日：1990-05-15

Applicant: AGENCY IND SCIENCE TECHN ,  HITACHI CHEMICAL CO LTD

Inventor： IWAKURA MASAHIRO ,  OHASHI SHINICHI ,  TANAKA YOSHIO ,  BABA KENZO ,  IZUTSU HIROSHI ,  OBARA KAZUHIKO ,  TAKASUKA AKIKO

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/44 ,  A61P37/08 ,  C07K1/22 ,  C07K14/00 ,  C07K19/00 ,  C12N1/21 ,  C12N15/12 ,  C12N15/53 ,  C12N15/62 ,  C12P21/02 ,  C12R1/19

Abstract: NEW MATERIAL:A recombinant plasmid containing a base sequence encoding dihydrofolate reductase-antiallergic peptide fused protein. EXAMPLE:Plasmid pBBK10MM. USE:Production of DSDGK. PREPARATION:DNAs shown by formula II and formula III are chemically synthesized and a duplex DNA shown by formula TV is obtained by annealing. Recombinant plasmid pMEK2 is cleft with BamHI and XhoI to give a DNA fragment, which is linked to the duplex DNA shown by formula TV with T4-DNA ligase to give new plasmid pBBK10MM.

公开(公告)号：JPH02231466A

公开(公告)日：1990-09-13

申请号：JP10562488

申请日：1988-04-28

Applicant: AGENCY IND SCIENCE TECHN

Inventor： TANAKA YOSHIO ,  SAKURABA EIGO

IPC: C07B53/00 ,  C07C315/02 ,  C07C317/04 ,  C07C317/14 ,  C07F17/02

Abstract: PURPOSE:To obtain the subject substance useful as medicine, bioactive substance or asymmetric synthetic intermediate in high yield by including sulfides in cyclodextrin and bringing into contact with oxidizer in dispersion. CONSTITUTION:Sulfides expressed by the formula R SR (R and R are alkyl, aryl, allyl, alkenyl, alkinyl or aralkyl, etc., may be substituted) are included in cyclodextrin (all of alpha, beta and gamma may be used) by kneading method or solution method and resultant clathrate compound is dispersed in organic solvent or water, etc., with screening light, then oxidizer is added, thus reacted at from -20 to 50 deg.C for 2-150 hour to afford the subject substance. In the above- mentioned method, purification is easy and cost is low as using cyclic oligosaccharide stable and repeatedly usable without toxicity in a lower cost than conventional optically active catalyst, and further optical purity of generated substance is high.

公开(公告)号：JPH02142476A

公开(公告)日：1990-05-31

申请号：JP29420488

申请日：1988-11-21

Applicant: AGENCY IND SCIENCE TECHN

Inventor： IWAKURA MASAHIRO ,  OHASHI SHINICHI ,  TANAKA YOSHIO

IPC: C12N15/09 ,  C07K14/00 ,  C07K14/575 ,  C07K14/60 ,  C07K19/00 ,  C12N1/21 ,  C12N15/18 ,  C12N15/62 ,  C12P21/02 ,  C12R1/19

Abstract: NEW MATERIAL:A recombinant plasmid pGRFM44-6 stably replicated in Esherichia coli, capable of giving trimethoprim resistance and amplicillin resistance to the Escherichia coli as a host and coding the fused protein of a bovine growth hormone-releasing factor derivative having an amino acid sequence of the formula with a dihydrofolic acid reductase. USE:For the production of a bovine growth hormone-releasing factor (GRS) and a dihydrofolic acid reductase(DHFR). PREPARATION:For example, a recombinant plasmid pSG1-12 coding DHFR and the sequence of Np.1-29 amino acids of bovine GRF is treated with a restriction enzyme. The produced DNA fragment is combined with a synthetic DNA coding the sequence of No.29-44 amino acids of the GRF and subsequently inserted into an Escherichia coli, followed by culturing the Esherichia coli and screening the cultured colony thereof the select a clone producing DHFR-GRF, thereby providing the pGRFM44-6.

公开(公告)号：JPH0227246A

公开(公告)日：1990-01-30

申请号：JP17773288

申请日：1988-07-15

Applicant: AGENCY IND SCIENCE TECHN

Inventor： MORIMOTO SATOSHI ,  TANAKA YOSHIO ,  ITO MASAJIRO

IPC: G01K17/00 ,  G01K17/06 ,  G01N25/20 ,  G01N25/48

Abstract: PURPOSE:To enable direct measurement of changes with time at a high accuracy in mixing, dilution and reaction by employing a series/linear detector or detectors as calorific value detectors to insert a heat insulating plate in the course thereof. CONSTITUTION:A polyethylene tube having a manganin wire 4 wound in a coil as electric resistance wire on detectors (e.g. thermomodule) 1 arranged in a series and linearly is used for a sample path tube 3 and arranged zigzag. The detectors are divided by three, for instance, and are isolated from one another with a poorly heat conducting teflon plate 5 together with metallic heat sinks 2 supporting them. The detectors 1 are screwed down 6 on a semi- cylindrical thermostat heat sink 7 and a thermostat 7 is laid thereon utilizing a screw hole 8 to form a detection unit. Two kinds of fluids to be measured enter at an inlet 9 of the tube 3, mixed to react and then, discharged 10. Thus, groups of three detectors work independently as calorific value detection unit thereby enabling a wide ranging measurement of changes with time with a varying of a flow velocity.

公开(公告)号：JPH01266276A

公开(公告)日：1989-10-24

申请号：JP9460788

申请日：1988-04-19

Applicant: AGENCY IND SCIENCE TECHN ,  MASUMI KK ,  OMIYA SEIREN KK

Inventor： HAYASHI YOSHIYUKI ,  TANAKA YOSHIO ,  SHIOZAWA KAZUO

IPC: D06M13/02 ,  D06M13/11 ,  D06M13/165 ,  D06M101/00 ,  D06M101/02 ,  D06M101/10 ,  D06M101/12

Abstract: PURPOSE:To improve wear resistance, yellowing and browing resistance, wrinkle resistance, etc., of silk yarn product, by dissolving an epoxy compound and a reaction catalyst in a mixed solution of a polar approtic solvent and water to give a composition, impregnating the composition into a silk yarn product and subjecting the yarn to wet heat treatment. CONSTITUTION:An epoxy compound such as a compound having two or more epoxy groups and =100 deg.C boiling point, such as dimethyl sulfoxide and water in the weight ratio of 95:5-51:49 to prepare a composition, which is impregnated into a silk yarn product, pressed and then the silk yarn product is subjected to wet heat treatment in high-temperature steam at >=100 deg.C to readily improve functions such as wear resistance, yellowing and browning resistance, wetting resistance, wrinkle resistance and washing resistance while maintaining characteristic properties of silk yarn.

公开(公告)号：JPH01242681A

公开(公告)日：1989-09-27

申请号：JP6929588

申请日：1988-03-25

Applicant: AGENCY IND SCIENCE TECHN ,  NISSEI KK

Inventor： TANAKA YOSHIO ,  IKEDA YASUHIRO

IPC: C04B41/63 ,  B22F3/26 ,  C04B41/83 ,  C09K3/10

Abstract: PURPOSE:To obtain the title long-life impregnating agent which can cure at relatively low temperature within a short time without causing volume shrinkage, by using a polymerizable vinyl monomer containing an ethylenically unsaturated compound and a cyclodextrin clathrate compound as components. CONSTITUTION:The title impregnating agent is obtained by mixing a polymerizable vinyl monomer (A) containing at least one compound selected from among ethylenically unsaturated compounds each having at least one member selected from among a bicycloorthoester group of formula I [wherein R is a group of formula II (wherein R is H or CH3, R is any arbitrary organic residue), an ethylenically unsaturated group of formula III or the like, and R is H or any arbitrary organic residue], a spirocarbonate group of formula IV (wherein R is any arbitrary organic residue), a spiroorthoester group of formula V (wherein R -R are each H, any arbitrary organic residue or the like, at least one of them is an alkenyl, R and R , or R and R may be combined together to form a methylene group, and R and R , or R and R may be combined together to form a group of formula VI or VII, and R -R may be combined together to form a monocyclic or polycyclic ring, and A is any arbitrary organic residue), etc., with a cyclodextrin clathrate compound (B) prepared by treating a polymerization initiator with a cyclodextrin.

公开(公告)号：JPH01213235A

公开(公告)日：1989-08-28

申请号：JP3885788

申请日：1988-02-22

Applicant: AGENCY IND SCIENCE TECHN

Inventor： TANAKA YOSHIO ,  SAKURABA EIGO

IPC: C08B30/18 ,  C07B41/02 ,  C07B53/00 ,  C07C27/00 ,  C07C29/136 ,  C07C29/143 ,  C07C31/125 ,  C07C33/20 ,  C07C33/46 ,  C07C67/00

Abstract: PURPOSE:To obtain the subject compound which is a synthetic intermediate for neurontransmitters, antitumor substances, etc., in high optical purity, by bringing a specific carbonyl compound into contact with a reducing agent complex prepared by including a reducing agent in cyclodextrin using a readily available and inexpensive raw material. CONSTITUTION:A reducing agent complex prepared by including a reducing agent in cyclodextrin in a powdery form is directly dispersed in a supersaturated aqueous solution of various inorganic salts or organic solvent by cutting off light and a carbonyl compound having an optional organic residue without interfering reductive reaction is added and reacted therewith at -60-90 deg.C, preferably -20-50 deg.C for 5-100hr to afford the aimed compound. Furthermore, the reducing agent used is preferably a Lewis base complex of borane. The clathrate compound of the reducing agent is obtained by, e.g., adding water (in an amount of about 0.1-6 times based on the cyclodextrin) to the cyclodextrin and kneading the resultant pasty mixture with a reducing agent compound to be included.

公开(公告)号：JPS6433182A

公开(公告)日：1989-02-03

申请号：JP18896987

申请日：1987-07-30

Applicant: AGENCY IND SCIENCE TECHN ,  NISSEI KK

Inventor： TANAKA YOSHIO ,  IKEDA YASUHIRO

IPC: C07D493/10 ,  C07D493/08 ,  C08F16/14 ,  C08F16/26 ,  C08F16/32 ,  C08F16/38 ,  C08F20/26 ,  C08F24/00 ,  C09K3/10 ,  C09K3/12

Abstract: PURPOSE:To obtain the title impregnating agent low in volume shrinkage during curing and useful for sealing the pores of a porous body, by mixing a specified polymerizable vinyl monomer with a polymerization initiator. CONSTITUTION:A polymerizable vinyl monomer containing at least one member (a) selected from among a (meth) acrylic ester (i) of formula I (wherein R is H or CH3, R is a 1-18C linear or branched alkyl, an aryl or the like and R is H, R , an alkenyl or the like), an ethylenically unsaturated bicyclo ortho ester (ii) of formula II (wherein R is R ), a spirocarbonate (iii) of formula III (wherein R is either of formulas IV-V, and m, n and l are each 1-18), and a spiro ortho ester (iv) of formula VI [wherein R are each H, a (halogenated) alkyl, an alkenyl or the like, and at least one of R is an alkenyl, either R and R or R and R may be combined together to form methylene, either R and R or R and R may be combined together to form a group of either of formulas VII-VIII, R may be combined together to form a monocyclic or polycyclic ring, and A is a (halogenated) alkyl, an aryl or the like] with a polymerization initiator (b) such as a peroxide or an azo compound.