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41.发明公开N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS 有权N3-ALKYLIER BENZIMIDAZOL-DERIVATE ALS MEK-HEMMER
公开(公告)号：EP1663210A4
公开(公告)日：2009-04-22
申请号：EP04781809
申请日：2004-08-20
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI M , LYSSIKATOS JOSEPH P , MARLOW ALLISON L , HURLEY BRIAN T , KOCH KEVIN
IPC: A61K31/4184 , C07D235/06 , C07D235/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/6506 , C07F9/6558
CPC classification number: C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
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公开(公告)号：EP1879886A4
公开(公告)日：2010-09-08
申请号：EP06758821
申请日：2006-05-01
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , ALLEN SHELLEY , LAIRD ELLEN , LYSSIKATOS JOSEPH P , ROBINSON JOHN E , CORRETTE CHRISTOPHER P , DELISLE ROBERT KIRK , VOEGTLI WALTER CHARLES
IPC: C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：EP1689406A4
公开(公告)日：2007-01-17
申请号：EP04811721
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , HURLEY T BRIAN , BLAKE JIM , MARLOW ALLISON L
IPC: C07D471/04 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/4353 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , A61P35/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D487/02 , C07D487/04 , C07D491/02 , C07D498/02 , C07D498/04
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
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公开(公告)号：RS51861B2
公开(公告)日：2018-03-30
申请号：RSP20110131
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM
IPC: C07D213/80 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/4353 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , A61P35/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
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公开(公告)号：PL2467377T3
公开(公告)日：2017-10-31
申请号：PL10810563
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
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Patent Agency Ranking
公开(公告)号：HUE032638T2
公开(公告)日：2017-10-30
申请号：HUE12733896
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
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公开(公告)号：PL2663555T3
公开(公告)日：2017-08-31
申请号：PL12733896
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY CHARLES TODD , GRONEBERG ROBERT D , JONES ZACHARY , LYSSIKATOS JOSEPH P , YANG HONG WOON
IPC: A61K31/55 , A61P37/00 , C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
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公开(公告)号：CA2734831C
公开(公告)日：2017-04-18
申请号：CA2734831
申请日：2009-08-18
Applicant: ARRAY BIOPHARMA INC
Inventor： ALLEN SHELLEY , CELESTE LAURA L , DAVIS T GREGG , DELISLE ROBERT KIRK , GRESCHUK JULIE MARIE , GROSS STEFAN D , HICKEN ERIK JAMES , JACKSON LEILA J , LYSSIKATOS JOSEPH P , KALLAN NICHOLAS C , MARMSAETER FREDRIK P , MUNSON MARK C , PHENEGER JED , RAST BRYSON , ROBINSON JOHN E , SCHLACHTER STEPHEN T , TOPALOV GEORGE T , WRIGHT A DALE , ZHAO QIAN
IPC: C07D471/04 , A61K31/47
Abstract: Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.
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公开(公告)号：AU2017200937A1
公开(公告)日：2017-03-02
申请号：AU2017200937
申请日：2017-02-10
Applicant: ARRAY BIOPHARMA INC , VENTIRX PHARMACEUTICALS INC
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC: C07D223/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D401/14 , C07D403/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
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公开(公告)号：CY1114592T1
公开(公告)日：2016-10-05
申请号：CY131100995
申请日：2013-11-08
Applicant: ARRAY BIOPHARMA INC
Inventor： ALLEN SHELLEY , CELESTE LAURA L , DAVIS T GREGG , DELISLE ROBERT KIRK , GRESCHUK JULIE MARIE , GROSS STEFAN D , HICKEN ERIK JAMES , JACKSON LEILA J , LYSSIKATOS JOSEPH P , KALLAN NICHOLAS C , MARMSΑTER FREDRIK P , MUNSON MARK C , PHENEGER JED , RAST BRYSON , ROBINSON JOHN E , SCHLACHTER STEPHEN T , TOPALOV GEORGE T , WRIGHT A DALE , ZHAO QIAN
IPC: C07D471/04 , A61K31/47
Abstract: ΕνώσειςτουΤύπου (Ι), όπουταΑ, Β, R1, R1a, R2, R3, R4, R5, R6 και R7 έχουντιςέννοιεςπουδίδονταιστηνπροδιαγραφή, είναιαναστολείςυποδοχέατυροσίνηςχρήσιμοιστηθεραπείαασθενειώνκαιδιαταραχώνπουσυνδυάζονταιμεανοσοκύτταρο, όπωςφλεγμονωδώνκαιαυτοάνοσωνδιαταραχών.
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