公开(公告)号：PT1997809E

公开(公告)日：2014-08-26

申请号：PT08164856

申请日：2004-02-25

Applicant: ARRAY BIOPHARMA INC

Inventor： GRONEBERG ROBERT ,  MUNSON MARK ,  RIZZI JAMES ,  MARESKA DAVID A ,  KIM GANGHYEOK ,  VIGERS GUY ,  RAO CHANG ,  HARVEY DARREN ,  KIM YOUNGBOO ,  BALACHARI DEVAN ,  RODRIGUEZ MARTHA

IPC: C07D231/56 ,  A61K20060101 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/42 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  C07D20060101 ,  C07D261/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

公开(公告)号：SI1997810T1

公开(公告)日：2013-12-31

申请号：SI200432103

申请日：2004-02-25

Applicant: ARRAY BIOPHARMA INC

Inventor： MUNSON MARK ,  MARESKA DAVID A ,  KIM YOUNGBOO ,  GRONEBERG ROBERT ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  KIM GANGHYEOK ,  VIGERS GUY ,  RAO CHANG ,  BALACHARI DEVAN ,  HARVEY DARREN

IPC: C07D401/00 ,  A61K20060101 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  C07D20060101 ,  C07D231/00 ,  C07D231/56 ,  C07D261/20 ,  C07D401/14 ,  C07D403/00 ,  C07D403/04 ,  C07D403/12 ,  C07D405/00 ,  C07D405/12 ,  C07D413/12 ,  C07D471/00 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

公开(公告)号：DK1997810T3

公开(公告)日：2013-10-21

申请号：DK08164860

申请日：2004-02-25

Applicant: ARRAY BIOPHARMA INC

Inventor： MUNSON MARK ,  MARESKA DAVID A ,  GRONEBERG ROBERT ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  KIM GANGHYEOK ,  VIGERS GUY ,  RAO CHANG ,  BALACHARI DEVAN ,  KIM YOUNGBOO ,  HARVEY DARREN

IPC: C07D401/14 ,  A61K20060101 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  C07D20060101 ,  C07D231/56 ,  C07D261/20 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

公开(公告)号：SG191129A1

公开(公告)日：2013-07-31

申请号：SG2013045349

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：DK2039685T3

公开(公告)日：2013-03-25

申请号：DK08166014

申请日：2004-02-25

Applicant: ARRAY BIOPHARMA INC

Inventor： BALACHARI DEVAN ,  KIM YOUNGBOO ,  MUNSON MARK ,  MARESKA DAVID A ,  GRONEBERG ROBERT ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  KIM GANGHYEOK ,  VIGERS GUY ,  RAO CHANG ,  HARVEY DARREN

IPC: C07D401/04 ,  A61K20060101 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/42 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  C07D20060101 ,  C07D231/56 ,  C07D261/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

公开(公告)号：AU2012247083A1

公开(公告)日：2012-11-29

申请号：AU2012247083

申请日：2012-11-13

Applicant: ARRAY BIOPHARMA INC

Inventor： MUNSON MARK ,  MARESKA DAVID A ,  KIM YOUNGBOO ,  GRONEBERG ROBERT ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  KIM GANGHYEOK ,  VIGERS GUY ,  RAO CHANG ,  BALACHARI DEVAN ,  HARVEY DARREN

IPC: C07D231/56 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  C07D261/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

Abstract: Compounds having the Formula: [ U wherein Y, A, W, B, U, V, X and Ar have the meanings given in the specification, which compounds are useful in therapy as p38-inhibitors.

公开(公告)号：CA3027814A1

公开(公告)日：2012-06-21

申请号：CA3027814

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDERIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04

Abstract: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：IL170527A

公开(公告)日：2011-11-30

申请号：IL17052705

申请日：2005-08-28

Applicant: ARRAY BIOPHARMA INC ,  MUNSON MARK ,  MARESKA DAVID A ,  KIM YOUNGBOO ,  GRONEBERG ROBERT ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  VIGERS GUY ,  RAO CHANG ,  BALACHARI DEVAN ,  HARVEY DARREN ,  KIM GANHYEOK

Inventor： MUNSON MARK ,  MARESKA DAVID A ,  KIM YOUNGBOO ,  GRONEBERG ROBERT ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  VIGERS GUY ,  RAO CHANG ,  BALACHARI DEVAN ,  HARVEY DARREN ,  KIM GANHYEOK

IPC: A61K20060101 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  C07D20060101 ,  C07D231/56 ,  C07D261/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

Abstract: Compounds having the Formula: wherein Y, A, W, B, U, V, X and Ar 1 have the meanings given in the specification, which compounds are useful in therapy as p38-inhibitors.

公开(公告)号：NZ582796A

公开(公告)日：2011-05-27

申请号：NZ58279604

申请日：2004-02-25

Applicant: ARRAY BIOPHARMA INC

Inventor： MUNSON MARK ,  MARESKA DAVID A ,  KIM YOUNGBOO ,  GRONEBERG ROBERT ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  KIM GANGHYEOK ,  VIGERS GUY ,  RAO CHANG ,  BALACHARI DEVAN ,  HARVEY DARREN

IPC: A61K31/675 ,  A61K20060101 ,  A61K31/4745 ,  A61K31/503 ,  C07D20060101 ,  C07D231/56 ,  C07D261/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

Abstract: Disclosed is a pyrazol-indazol-pyridin derivative compound represented by the formula shown herein, its resolved enantiomers, diastereoisomers, solvates and pharmaceutically acceptable salts thereof, wherein the substituents are as defined in the specification. Also disclosed are compositions comprising the benzimidazole compound and their use in the manufacture of a medicament for the treatment of p38-mediated conditions selected from inflammatory disease, autoimmune disease, destructive bone disorder, proliferative disorder, infectious disease, viral disease and neurodegenerative disease. (62) Divided Out of 572694

公开(公告)号：CL2009000234A1

公开(公告)日：2009-04-24

申请号：CL2009000234

申请日：2009-02-03

Applicant: ARRAY BIOPHARMA INC

Inventor： GRONEBERG ROBERT D ,  RIZZI JAMES ,  GANGHYEOK KIM ,  MARESKA DAVID A ,  MUNSON MARK ,  RODRIGUEZ MARTHA ,  VIGERS GUY ,  YOUNGBOO KIM ,  RAO CHANG ,  BALACHARI DEVAN ,  HARVEY DARREN

IPC: A61K31/416 ,  A61K20060101 ,  A61K31/42 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D20060101 ,  C07D213/64 ,  C07D231/38 ,  C07D231/56 ,  C07D261/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

Abstract: SE DESCRIBEN COMPUESTOS DERIVADOS DE HETEROARIL-FENILO BICICLICOS, DE FÓRMULA GENERAL EN DONDE RX. RY, Q. X. Y, N, W, U, V, G, J, K Y T, SON TALES COMO SE DEFINEN EN EL PLIEGO DE REIVINDICACIONES; SE DESCRIBE TAMBIÉN UNA COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE Y SU USO EN EL TRATAMIENTO DE LA INFLAMACIÓN , ENFERMEDAD AUTOINMUNE, TRASTORNOS ÓSEOS DESTRUCTIVOS, TRASTORNO PROLIFERATIVO, INFECCIONES BACTERIANAS Y VIRALES, ENFERMEDAD NEURODEGENERATIVA.