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公开(公告)号：JP2012251003A
公开(公告)日：2012-12-20
申请号：JP2012212497
申请日：2012-09-26
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: C07D231/56 , A61K20060101 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/496 , A61K31/503 , A61K31/5377 , A61K31/675 , A61P19/10 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/12 , A61P37/06 , A61P43/00 , C07D20060101 , C07D261/20 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide compounds inhibiting p38 alpha and related p38 interstitial events, for instance inhibiting cytokine production, a method for preparing these compounds, and pharmaceutical compositions containing these compounds.SOLUTION: The compounds expressed by the chemical formula are useful for treatment as a p38 inhibitor. Such compounds are called 2-aza-[4.3.0] bicyclic heteroaromatic rings in general, and are useful as a therapeutic agent for diseases which can be treated by inhibiting the p38 signal transduction pathway.
Abstract translation: 待解决的问题：提供抑制p38α和相关p38间质事件的化合物，例如抑制细胞因子产生，制备这些化合物的方法和含有这些化合物的药物组合物。 解决方案：由化学式表示的化合物可用作p38抑制剂的治疗。 这种化合物通常称为2-氮杂 - [4.3.0]双环杂芳环，并且可用作可通过抑制p38信号转导途径治疗的疾病的治疗剂。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP2009102395A
公开(公告)日：2009-05-14
申请号：JP2009012496
申请日：2009-01-23
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: C07D231/56 , A61K20060101 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4745 , A61K31/496 , A61K31/503 , A61K31/5377 , A61K31/675 , A61P1/04 , A61P17/06 , A61P19/02 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07D20060101 , C07D261/20 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide compounds which inhibit p38α and related p38 mediation event, for example inhibit cytokine production, methods of producing these compounds, and pharmaceutical compositions containing these compounds. SOLUTION: The compounds are represented by the formula, wherein Y, A, W, B, U, V, X and Ar 1 have the meanings given in the specification, and are useful in therapy as p38-inhibitors. Such compounds are generally called 2-aza-[4.3.0]bicyclic heteroaromatic ring, and are useful as therapeutic substances of diseases which can be treated by inhibition of a p38 signaling pathway. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 待解决的问题：提供抑制p38α和相关p38介导事件的化合物，例如抑制细胞因子产生，产生这些化合物的方法和含有这些化合物的药物组合物。 解决方案：化合物由下式表示，其中Y，A，W，B，U，V，X和Ar
1具有说明书中给出的含义，并且可用于治疗 作为p38-抑制剂。 这些化合物通常称为2-氮杂 - [4.3.0]二环杂芳环，并且可用作可通过抑制p38信号通路治疗的疾病的治疗物质。 版权所有（C）2009，JPO＆INPIT -
3.发明申请BICYCLIC COMPOUNDS HAVING BRADYKININ RECEPTORS AFFINITY AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开具有BRADYKININ受体亲和性的双环化合物及其药物组合物
公开(公告)号：WO2004092116A8
公开(公告)日：2005-05-06
申请号：PCT/US2004011105
申请日：2004-04-12
Applicant: AMGEN INC , ARRAY BIOPHARMA INC , GRONEBERG ROBERT D , ASKEW BEN , D AMICO DERIN C , ZHAN JAMES , TORO ANDRAS , SUZUKI HIDEO , MARESKA DAVID A , HAN NIANH , FOTSCH CHRISTOPHER H , LIU QINGLAN , RIAHI BABAK , YANG KEVIN , LI AIWAN , YUAN CHESTER , BISWAS KAUSTAV , HARRIED SCOTT , NGUYEN TOM , QIAN WENYUAN , CHEN JIAN J , NOMAK RANA
Inventor： GRONEBERG ROBERT D , ASKEW BEN , D AMICO DERIN C , ZHAN JAMES , TORO ANDRAS , SUZUKI HIDEO , MARESKA DAVID A , HAN NIANH , FOTSCH CHRISTOPHER H , LIU QINGLAN , RIAHI BABAK , YANG KEVIN , LI AIWAN , YUAN CHESTER , BISWAS KAUSTAV , HARRIED SCOTT , NGUYEN TOM , QIAN WENYUAN , CHEN JIAN J , NOMAK RANA
IPC: A61K31/18 , A61K31/277 , A61K31/405 , A61K31/47 , A61P25/04 , A61P29/00 , C07C311/19 , C07C311/29 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08 , C07C311/18 , A61K31/33 , A61K31/34 , C07D279/00
CPC classification number: C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：WO2004078116A2
公开(公告)日：2004-09-16
申请号：PCT/US2004005693
申请日：2004-02-25
Applicant: ARRAY BIOPHARMA INC , MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: A61K20060101 , A61K31/4745 , A61K31/503 , A61K31/675 , C07D20060101 , C07D231/56 , C07D261/20 , C07D401/14 , C07D403/04 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , A61K
CPC classification number: C07D471/04 , C07D231/56 , C07D261/20 , C07D413/12
Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.
Abstract translation: 本发明涉及p38的抑制剂及其制备方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防由p38介导的各种疾病的方法。
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公开(公告)号：WO2004078116A9
公开(公告)日：2008-09-12
申请号：PCT/US2004005693
申请日：2004-02-25
Applicant: ARRAY BIOPHARMA INC , MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: A61K31/4745 , A61K20060101 , A61K31/503 , A61K31/675 , C07D20060101 , C07D231/56 , C07D261/20 , C07D401/14 , C07D403/04 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02
CPC classification number: C07D471/04 , C07D231/56 , C07D261/20 , C07D413/12
Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.
Abstract translation: 本发明涉及p38的抑制剂及其制备方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防由p38介导的各种疾病的方法。
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Patent Agency Ranking6.发明公开
公开(公告)号：EP1997809A8
公开(公告)日：2009-01-14
申请号：EP08164856
申请日：2004-02-25
Applicant: ARRAY BIOPHARMA INC
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: C07D231/56 , A61K20060101 , A61K31/416 , A61K31/4162 , A61K31/42 , A61K31/4745 , A61K31/503 , A61K31/675 , C07D20060101 , C07D261/20 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
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公开(公告)号：EP2375899A4
公开(公告)日：2012-06-06
申请号：EP10729483
申请日：2010-01-07
Applicant: ARRAY BIOPHARMA INC
Inventor： RODRIGUEZ MARTHA E , MARESKA DAVID A , HANS JEREMY J , HARVEY DARREN M , GRONEBERG ROBERT D , O'SULLIVAN MICHAEL
IPC: A61K31/445 , A61P3/10 , A61P9/10 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D471/04
CPC classification number: C07D413/14 , A61K31/445 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/14 , C07D471/04
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公开(公告)号：EP1606283A4
公开(公告)日：2007-05-23
申请号：EP04714621
申请日：2004-02-25
Applicant: ARRAY BIOPHARMA INC
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: A61K20060101 , A61K31/4745 , A61K31/503 , A61K31/675 , C07D20060101 , C07D231/56 , C07D261/20 , C07D401/14 , C07D403/04 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , A61K31/416 , A61K31/4162 , A61P35/00
CPC classification number: C07D471/04 , C07D231/56 , C07D261/20 , C07D413/12
Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号：CY1116207T1
公开(公告)日：2017-02-08
申请号：CY151100383
申请日：2015-04-27
Applicant: ARRAY BIOPHARMA INC
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: C07D231/56 , A61K20060101 , A61K31/416 , A61K31/4162 , A61K31/42 , A61K31/4745 , A61K31/503 , A61K31/675 , A61P35/00 , C07D20060101 , C07D261/20 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
Abstract: ΕνώσειςοιοποίεςέχουντονΤύπο: όπουταΥ, W, U, V, Χ, G, J, Κ, Τ, Rx, Q και Ry έχουντιςέννοιεςοιοποίεςδίδονταιειςτηνπεριγραφή, είναιαναστολείςτης p38, χρήσιμεςειςτηθεραπεία.
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公开(公告)号：SI1997811T1
公开(公告)日：2015-07-31
申请号：SI200432236
申请日：2004-02-25
Applicant: ARRAY BIOPHARMA INC
Inventor： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: C07D231/00 , A61K20060101 , A61K31/00 , A61K31/4745 , A61K31/503 , A61K31/675 , A61P35/00 , C07D20060101 , C07D231/56 , C07D261/00 , C07D261/20 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/00 , C07D413/12 , C07D471/00 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
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